scholarly journals Basis of Clinical Pharmacology for an Appropriate and Beneficial Clinical Use of a Medicine: 5. Drug Therapy and Pharmacokinetic Changes in Pregnancy and Lactation

Author(s):  
SHUNJI MATSUKI
ESC CardioMed ◽  
2018 ◽  
pp. 2876-2882
Author(s):  
Stefan Verlohren

Pregnant women with pre-existing cardiovascular disease may require drug therapy during their pregnancy and lactation period. There are no uniform recommendations for selection of medications, dosing, and timing of treatment. Possible adverse or teratogenic effects of the drugs on the fetus must be weighed against the maternal indication of drug treatment. This chapter gives an overview of medical treatment options for cardiovascular diseases in pregnancy. Furthermore, sources of evidence which can be used for risk classification of drugs applied during pregnancy are shown.


1998 ◽  
Vol 82 (4) ◽  
pp. 58I-62I ◽  
Author(s):  
Theodore Chow ◽  
Joseph Galvin ◽  
Brian McGovern

2015 ◽  
Vol 13 (2) ◽  
pp. 605 ◽  
Author(s):  
Juan F. Mosley II ◽  
Lilian L. Smith ◽  
Megan D. Dezan

1962 ◽  
Vol 40 (3) ◽  
pp. 430-440 ◽  
Author(s):  
K. E. Arosenius ◽  
H. Derblom ◽  
G. Nylander

ABSTRACT The offspring of bitches treated with thiouracil during pregnancy and lactation were studied with regard to certain aspects of iodine metabolism and also to the morphological effect on the thyroid gland, as compared with controls of the same age and weight. At the age of six months, when the dogs were virtually fully grown, the thyroid gland still exhibited the effects of the thiouracil treatment of the mothers as manifested by an increased uptake of 131I, enlargement, and histological changes of a hyperplastic type. The significance of these deviations from normal iodine metabolism and morphology is discussed with particular reference to the dangers of thiouracil medication during pregnancy.


Author(s):  
Ashley D. Davidson ◽  
Amritha Bhat ◽  
Frances Chu ◽  
Jessie N. Rice ◽  
N. Aba Nduom ◽  
...  

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