DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE ANGIOGRAPHY OF Gd-TTDA-BOM COMPARED WITH Gd-DTPA IN NORMAL RAT AT 3T

2014 ◽  
Vol 26 (02) ◽  
pp. 1450027
Author(s):  
Jo-Chi Jao ◽  
Yen-Ku Chen ◽  
Twei-Shiun Jaw ◽  
Yun-Ming Wang ◽  
Po-Chou Chen
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Vascular Diseases ◽  
Signal Enhancement ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Normal Rat ◽  
Reorientation Time ◽  
Phantom Studies

Dynamic contrast-enhanced magnetic resonance angiography (DCE-MRA) is a good modality for the diagnosis of vascular diseases. Contrast agents that produce higher and longer enhancement in vessels are highly valued. The complex of gadolinium with (R,S)-4-carboxy-5,9,12-tris(carboxymethyl)-l-phenyl-2-oxa-5,9,12-triazatridecan-14-oic acid (Gd-TTDA-BOM) possesses a benzyloxymethyl group in the ligand TTDA-BOM with the capability of raising lipophilicity. The Gd-TTDA-BOM complex expresses higher and longer enhancement in mouse liver than that of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) because of its faster water exchange rate, higher reorientation time, and higher lipophilicity. Phantom studies have shown that Gd-TTDA-BOM has expressed with higher affinity to human serum albumin (HSA) than Gd-DTPA. In general, these characteristics might provide an advantage for vascular imaging. To verify this in vivo, a 3T MR scanner was used to investigate the signal enhancement in the aorta of normal rats by DCE-MRA after the bolus injection of Gd-TTDA-BOM and compared this with the injection of Gd-DTPA. Gd-TTDA-BOM expressed higher and longer signal enhancement in the aorta than Gd-DTPA. These results suggest that Gd-TTDA-BOM could provide better image quality than Gd-DTPA as an enhancement agent in DCE-MRA.

scholarly journals Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration—a randomized in vivo study in rabbits

2021 ◽  
Author(s):  
L. A. R. Righesso ◽  
M. Terekhov ◽  
H. Götz ◽  
M. Ackermann ◽  
T. Emrich ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Bone Regeneration ◽  
Blood Perfusion ◽  
Autogenous Bone ◽  
Resonance Imaging ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Abstract Objectives Micro-computed tomography (μ-CT) and histology, the current gold standard methods for assessing the formation of new bone and blood vessels, are invasive and/or destructive. With that in mind, a more conservative tool, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), was tested for its accuracy and reproducibility in monitoring neovascularization during bone regeneration. Additionally, the suitability of blood perfusion as a surrogate of the efficacy of osteoplastic materials was evaluated. Materials and methods Sixteen rabbits were used and equally divided into four groups, according to the time of euthanasia (2, 3, 4, and 6 weeks after surgery). The animals were submitted to two 8-mm craniotomies that were filled with blood or autogenous bone. Neovascularization was assessed in vivo through DCE-MRI, and bone regeneration, ex vivo, through μ-CT and histology. Results The defects could be consistently identified, and their blood perfusion measured through DCE-MRI, there being statistically significant differences within the blood clot group between 3 and 6 weeks (p = 0.029), and between the former and autogenous bone at six weeks (p = 0.017). Nonetheless, no significant correlations between DCE-MRI findings on neovascularization and μ-CT (r =−0.101, 95% CI [−0.445; 0.268]) or histology (r = 0.305, 95% CI [−0.133; 0.644]) findings on bone regeneration were observed. Conclusions These results support the hypothesis that DCE-MRI can be used to monitor neovascularization but contradict the premise that it could predict bone regeneration as well.

scholarly journals Utility of Contrast-Enhanced Magnetic Resonance Angiography for Delayed Intracranial In-Stent Stenosis in Nonatherosclerotic Cerebral Vascular Diseases

2017 ◽  
Vol 01 (02) ◽  
pp. 085-088
Author(s):  
Santhosh Kannath ◽  
Jayadevan Rajan ◽  
Kamble Harsha
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Vascular Diseases ◽  
Source Image ◽  
Tof Mra ◽  
Contrast Enhanced ◽  
Long Term Follow Up ◽  
Image Set ◽  
Stent Stenosis

AbstractNoninvasive imaging modalities are being used for long-term follow-up of intracranial stented patients of nonatherosclerotic etiology. The aim of this study is to determine the utility of contrast-enhanced magnetic resonance angiography (CE-MRA) source images in delayed intracranial in-stent stenosis. A total of 18 stented patients for nonatherosclerotic etiology were reviewed; all had follow-up digital subtraction angiography (DSA) and CE- and time-of-flight (TOF)-MRA. Four sets of MR images (TOF-MRA reformatted images, TOF-MRA source images, CE-MRA reformatted images, and CE-MRA source images) were reviewed for detection of ≥ 50% stenosis. Accuracy of each image set was calculated comparing to DSA. Overall delayed in-stent stenosis during follow-up DSA was 10%. The sensitivity of TOF reformatted image, TOF source image, CE-MRA reformatted image, CE-MRA source image are 33% (6/18), 55.6% (10/18), 77.8% (14/18), and 100% (18/18), respectively, while negative predictive value are 14.3% (2/14), 20% (2/10), 33% (2/6), and 100% (2/2), respectively. CE-MRA source images are equally efficacious as DSA to detect significant (≥ 50%) delayed in-stent stenosis.

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