Effect of date pits on oxidative damage and antioxidant defense systems in rat tissues

SciVee ◽  
2008 ◽  
Keyword(s):  
Oxidative Damage ◽  
Antioxidant Defense ◽  
Rat Tissues ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Date Pits

scholarly journals Effect of Date Pits on Oxidative Damage and Antioxidant Defense Systems in Rat Tissues

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Hosam H. Habib ◽  
Wissam H. Ibrahim
Keyword(s):  
Oxidative Damage ◽  
Antioxidant Defense ◽  
Rat Tissues ◽  
Defense Systems ◽  
Antioxidant Defense Systems ◽  
Date Pits

Effect of TiO2Nanoparticles on Oxidative Damage and Antioxidant Defense Systems in Chickpea Seedlings during Cold Stress

2014 ◽  
Vol 61 (6) ◽  
pp. 816-823
Author(s):  
R. Mohammadi ◽  
R. Maali-Amiri ◽  
N. L. Mantri
Keyword(s):  
Oxidative Damage ◽  
Cold Stress ◽  
Antioxidant Defense ◽  
Defense Systems ◽  
Antioxidant Defense Systems

scholarly journals Influence of Drought Stress on Oxidative Damage and Antioxidant Defense Systems in Tolerant and Susceptible Wheat Genotypes

2012 ◽  
Vol 4 (8) ◽  
Author(s):  
Hojjat Hasheminasab ◽  
Mohammad Taghi Assad ◽  
Ali Aliakbari ◽  
Seyyed Rasoul Sahhafi
Keyword(s):  
Drought Stress ◽  
Oxidative Damage ◽  
Antioxidant Defense ◽  
Wheat Genotypes ◽  
Defense Systems ◽  
Antioxidant Defense Systems

scholarly journals Mitoubiquinol Mesylate Attenuated Diethyl Nitrosamine–Induced Hepatocellular Carcinoma Through Modulation of Mitochondrial Antioxidant Defense Systems

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 9-9
Author(s):  
Adisa Rahmat Adetutu ◽  
Sulaimon Lateef Adegboyega ◽  
Okeke Ebele Geraldine ◽  
Ariyo OC ◽  
Abdulkareem Fatimah Biade
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Liver Function ◽  
Oxidative Damage ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Tumor Incidence ◽  
Defense Systems ◽  
Significant Difference ◽  
Antioxidant Defense Systems

PURPOSE Hepatocellular carcinoma (HCC) is a highly malignant cancer, with a high recurrence rate and a poor prognosis. Diethyl nitrosamine (DEN) cirrhosis HCC–induced model has revealed an association of cancer progression with oxidative stress and mitochondrial dysfunction. This study investigated the effects of mitoubiquinol mesylate (MitoQ), a mitochondrial targeted antioxidant derivative from ubiquinone on DEN-induced oxidative damage in HCC Wistar rats. METHODS Fifty male Wistar rats were randomly divided into 5 groups, 10 rats per group. Groups A, B, and C received distilled water 10 mL/kg DEN, and MitoQ orally for 16 weeks, respectively. Animals in group D were pretreated with MitoQ for 1 week followed by coadministration of MitoQ and DEN (protective effect), whereas group E received DEN for 8 weeks, then coadministration of DEN and MitoQ (therapeutic effect) until the end of the study. Survival index, tumor incidence, liver function indices, hematologic profile, mitochondrial respiratory enzymes, and antioxidant defense status were assessed. RESULTS Data obtained show that rats in groups D and E had 80% survival and decreased tumor incidence (40% and 60%, respectively) compared with group B. Similarly, MitoQ significantly ( P < .05) decreased the activities of liver function enzymes, while hemoglobin concentration, red blood cell count, and lymphocytes levels were significantly elevated compared with the DEN-only group. Furthermore, MitoQ significantly ( P < .05) protected the liver from DEN-induced oxidative damage; however, there was no significant difference ( P > .05) between activities of mitochondrial F1F0-ATPase and succinate dehydrogenase of groups A, B, D, and E, respectively, although these enzyme activities were significantly ( P < .05) elevated in group C. Macroscopic and microscopic features indicated a reversal of DEN-induced cellular degeneration in hepatocytes. CONCLUSION These data suggest that MitoQ treatment for 16 weeks attenuated DEN-induced oxidative stress indices via modulation of mitochondrial antioxidant defense systems and could alleviate the burden of HCC as a chemotherapeutic agent.

scholarly journals Screening Effects of Methanol Extracts of The Diplotaxis tenuifolia and Reseda lutea on The Enzymatic Antioxidant Defense Systems and Aldose Reductase Activity

2018 ◽  
Author(s):  
Naznoosh Shomali ◽  
Khalid Sharro Abdalrahman ◽  
Merve Gülşah Güneş ◽  
Belgin Sultan İşgör ◽  
Özlem Yıldırım
Keyword(s):  
Aldose Reductase ◽  
Antioxidant Defense ◽  
Reductase Activity ◽  
Enzymatic Antioxidant ◽  
Methanol Extracts ◽  
Defense Systems ◽  
Antioxidant Defense Systems

Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding

Hepatology ◽  
1989 ◽  
Vol 10 (5) ◽  
pp. 815-821 ◽  
Author(s):  
Tateo Kawase ◽  
Shinzo Kato ◽  
Charles S. Lieber
Keyword(s):  
Lipid Peroxidation ◽  
Rat Liver ◽  
Antioxidant Defense ◽  
Chronic Ethanol ◽  
Defense Systems ◽  
Ethanol Feeding ◽  
Antioxidant Defense Systems

Antioxidant Defense Systems

2021 ◽  
pp. 94-143
Author(s):  
Carmen Cecilia Espíndola Díaz
Keyword(s):  
Antioxidant Defense ◽  
Defense Systems ◽  
Antioxidant Defense Systems
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