Characteristics and Causes for Non-Accrued Clinical Research (NACR) at an Academic Medical Institution

Background: Recent literature and guidelines support treatment of severe acute exacerbation of COPD (AECOPD) with prednisone 40 mg (or equivalent) for 5 days. Objective: The purpose of this study was to determine whether systemic corticosteroids were being prescribed at the appropriate dose and duration in the treatment of severe AECOPD at a large academic medical institution. Methods: This was a single-center, retrospective, observational study conducted to evaluate corticosteroid prescribing patterns for adults admitted for severe AECOPD from March to May 2019 at a large academic medical institution. Appropriate therapy was defined as: prednisone 40 mg (or equivalent) for 5 days. The primary outcome was to determine the frequency of appropriate dose and duration. The secondary outcomes were to identify the frequency of appropriate dose or duration, compare the prevalence of adverse effects, such as new/worsening hyperglycemia or hypertension, and compare 30- and 90-day readmission rates. Results: Of the 190 patients included, 16 (8.4%) had an appropriate duration and 8 (4.2%) an appropriate dose. Only 4 patients (2.1%) had both appropriate corticosteroid dose and duration. New/worsening hyperglycemia occurred in 96 (50.5%), and hypertension developed in 13 (6.8%). Thirty-day readmission occurred in 46 (24.2%) and 90-day readmission in 78 (41.1%). These were more likely in those without appropriate dose and duration. Conclusion: Systemic corticosteroids for the treatment of severe AECOPD are not prescribed in accordance with evidence-based recommendations at this institution. This might result in a greater incidence of adverse effects and readmissions.

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Current State of Information Technologies for the Clinical Research Enterprise across Academic Medical Centers

Clinical and Translational Science ◽

10.1111/j.1752-8062.2011.00387.x ◽

2012 ◽

Vol 5 (3) ◽

pp. 281-284 ◽

Cited By ~ 17

Author(s):

Shawn N. Murphy ◽

Anil Dubey ◽

Peter J. Embi ◽

Paul A. Harris ◽

Brent G. Richter ◽

...

Keyword(s):

Clinical Research ◽

Information Technologies ◽

Academic Medical Centers ◽

Medical Centers ◽

Current State ◽

Academic Medical

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Ethics in clinical research

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2020.5.2.0091 ◽

2020 ◽

Vol 5 (2) ◽

pp. 012-018

Author(s):

Nagla Hussein Mohamed Khalid

Keyword(s):

Medical Education ◽

Clinical Research ◽

Ethical Issues ◽

Human Subjects ◽

Boards Of Trustees ◽

Independent Research ◽

Academic Medical ◽

Research On Human Subjects ◽

Human Participants ◽

The University

Ethics in medical education research is associated with any research concerning human participants and including anthropological tissue conducted by supervising and scholars of the University. It is associated with the accountability of the researcher, to be honest, and privacy and confidentially and autonomy and respectfully to all participants who affected by their research studies. Objectives of the review: The motivation behind this report is to look at the ethical issues raised when investigating including human members. In addition, to demonstrate the important ethical consideration with academic medical research. Conclusion: Ethics of restorative research on human subjects should be clinically supported and deductively stable. Educated consent is a compulsory segment of any clinical research. Investigators are committed to configuration look into protocols that build up guidelines of logical respectability, safeguard ethical and authoritative issues of the human subjects, and follow the conventions for forthcoming survey by independent research morals boards of trustees.

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Recent Trends in Primary Care Interest and Career Choices Among Medical Students at an Academic Medical Institution

Teaching and Learning in Medicine ◽

10.1080/10401334.2016.1206825 ◽

2016 ◽

Vol 29 (1) ◽

pp. 42-51 ◽

Cited By ~ 2

Author(s):

Chelsea J. Messinger ◽

Janet Hafler ◽

Ali M. Khan ◽

Theodore Long

Keyword(s):

Primary Care ◽

Medical Students ◽

Career Choices ◽

Medical Institution ◽

Academic Medical ◽

Recent Trends

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Perceived Institutional Barriers Among Clinical and Research Professionals: Minority Participation in Oncology Clinical Trials

JCO Oncology Practice ◽

10.1200/op.20.00970 ◽

2021 ◽

Vol 17 (5) ◽

pp. e666-e675 ◽

Cited By ~ 1

Author(s):

Soumya J. Niranjan ◽

Jennifer A. Wenzel ◽

Michelle Y. Martin ◽

Mona N. Fouad ◽

Selwyn M. Vickers ◽

...

Keyword(s):

Clinical Trials ◽

Clinical Research ◽

Community Outreach ◽

Institutional Factors ◽

Cancer Center ◽

Cancer Clinical Trials ◽

Minority Recruitment ◽

Institutional Barriers ◽

Medical Centers ◽

Academic Medical

PURPOSE: In general, participation rates in cancer clinical trials are very low. However, participation rates are especially low among the socially disadvantaged and racial and ethnic minority groups. These groups have been historically under-represented in cancer clinical trials. Although many patient-related barriers have been studied, institutional factors that are essential for building clinical research infrastructure around the clinical trial enterprise in academic medical centers have been underexplored. MATERIALS AND METHODS: We assessed perspectives of cancer center professional stakeholders on the institutional factors that can potentially influence racial and ethnic minority recruitment for cancer clinical trials. Ninety-one qualitative interviews were conducted at five US cancer centers among four stakeholder groups: cancer center leaders, principal investigators, referring clinicians, and research staff. Qualitative analyses examined response data focused on institutional factors related to minority recruitment for cancer clinical trials. RESULTS: Four prominent themes emerged regarding institutional barriers among clinical and research professionals. (1) There are no existing programs currently being used to recruit or retain minorities to clinical trials. (2) Institutional efforts are needed to increase trial participation and are not specific to potential minority participants. (3) Access to cancer clinical trials and navigation within an Academic Medical Center need to be simplified to better facilitate recruitment of minority patients. (4) Community outreach by cancer centers will increase clinical research awareness in the community. CONCLUSION: Our research highlights the need to address institutional barriers to improve the success of minority recruitment. To increase participation among minority populations, medical centers must address mutable institutional barriers such as setting specific minority recruitment goals for cancer clinical trials, ensuring that cancer clinical trials are accessible, especially to minority patients, and supporting sustained community outreach programs to increase clinical research awareness.

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