scholarly journals Radiosensitivity and Capacity to Recover from Radiation-Induced Damage in Pimonidazole-Unlabeled Intratumor Quiescent Cells Depend on p53 Status

2011 ◽  
Author(s):  
Masunaga
Keyword(s):  
Quiescent Cells ◽  
Radiation Induced ◽  
P53 Status

scholarly journals Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells

2002 ◽  
Vol 93 (12) ◽  
pp. 1366-1377 ◽  
Author(s):  
Shin-ichiro Masunaga ◽  
Koji Ono ◽  
Akihisa Takahashi ◽  
Yoshinori Sakurai ◽  
Ken Ohnishi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Neutron Beam ◽  
Reactor Neutron ◽  
Beam Irradiation ◽  
Quiescent Cells ◽  
P53 Status

Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes

2000 ◽  
Vol 466 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Polly Y Chang ◽  
Dorothea Torous ◽  
Louise Lutze-Mann ◽  
Richard Winegar
Keyword(s):  
Heavy Ion ◽  
Radiation Induced ◽  
P53 Status ◽  
Heavy Ion Radiation

Radiation-induced genetic instability in vivo depends on p53 status

2002 ◽  
Vol 502 (1-2) ◽  
pp. 69-80 ◽  
Author(s):  
Li Liang ◽  
Changshun Shao ◽  
Li Deng ◽  
Marc S. Mendonca ◽  
Peter J. Stambrook ◽  
...  
Keyword(s):  
Genetic Instability ◽  
Radiation Induced ◽  
P53 Status

scholarly journals p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Doseγ-Irradiation

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ines Höfig ◽  
Yashodhara Ingawale ◽  
Michael J. Atkinson ◽  
Heidi Hertlein ◽  
Peter J. Nelson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Low Dose ◽  
Telomere Shortening ◽  
Oxygen Levels ◽  
Multipotent Cells ◽  
Radiation Induced ◽  
P53 Status

Mesenchymal stem cells (MSCs) are a source of adult multipotent cells important in tissue regeneration. Murine MSCs are known to proliferate poorlyin vitrounder normoxia. The aim of this study is to analyze the interaction of nonphysiological high oxygen and low-doseγ-irradiation onto growth, senescence, and DNA damage. Tri-potent bone marrow-derived MSCs from p53 wildtype and p53−/− mice were cultured under either 21% or 2% O2. Long-term observations revealed a decreasing ability of wildtype mMSCs to proliferate and form colonies under extended culture in normoxia. This was accompanied by increased senescence under normoxia but not associated with telomere shortening. After low-doseγ-irradiation, the normoxic wildtype cells further increased the level of senescence. The number of radiation-inducedγH2AX DNA repair foci was higher in mMSCs kept under normoxia but not in p53−/− cells. P53-deficient MSCs additionally showed higher clonogeneity, lower senescence levels, and fewerγH2AX repair foci per cell as compared to their p53 wildtype counterparts irrespective of oxygen levels. These results reveal that oxygen levels together withγ-irradiation and p53 status are interconnected factors modulating growth capacity of BM MSCs in long-term culture. These efforts help to better understand and optimize handling of MSCs prior to their therapeutic use.

Radiation induced G1-block and p53 status in six human cell lines

1995 ◽  
Vol 37 (1) ◽  
pp. 20-28 ◽  
Author(s):  
F. Zölzer ◽  
S. Hillebrandt ◽  
C. Streffer
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines ◽  
Radiation Induced ◽  
P53 Status
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