Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing

To develop a wound dressing that can be removed from the injured skin without the damage and supporting rapid healing, we made hybrid dressing of small intestinal submucosa (SIS) and hydrogels. Alginate and gelatin used as a dressing material in hydrogels were selected to coat SIS sheets. Characteristics and tendency of wound healing of prepared sheets were investigated. Water uptake ability was greater when the sheets were coated with gelatin than alginate although both showed higher water absorption than the native SIS sheets, but the degradation rate of alginate/gelatin coated SIS was slower than that of native SIS because both polymers may delay contact time of enzyme to the SIS surface in solution. It was observed that less of fibroblasts attached to the natural polymer coated SIS sheets. This property will make easy for the detachment of the sheet from the defected tissue. Wound closure examination showed that prepared sheets enhanced wound healing. It was concluded that prepared alginate/gelatin coated SIS sheets are positively regarded as an appropriate biodegradable wound dressing that is reducing patient’s pain during change of the dressing.

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The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc

Advanced Biomaterials VII - Key Engineering Materials ◽

10.4028/0-87849-436-7.389 ◽

2007 ◽

pp. 389-392

Author(s):

Soon Hee Kim ◽

Bang Sil Choi ◽

Youn Kyung Ko ◽

Hyun Jung Ha ◽

Sun Jung Yoon ◽

...

Keyword(s):

Intervertebral Disc ◽

Small Intestinal Submucosa ◽

Small Intestinal ◽

Intestinal Submucosa

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Characterization of Fibronectin Derived from Porcine Small Intestinal Submucosa

Tissue Engineering ◽

10.1089/ten.1998.4.75 ◽

1998 ◽

Vol 4 (1) ◽

pp. 75-83 ◽

Cited By ~ 116

Author(s):

Timothy B. McPherson ◽

Stephen F. Badylak

Keyword(s):

Small Intestinal Submucosa ◽

Porcine Small Intestinal Submucosa ◽

Small Intestinal ◽

Intestinal Submucosa

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Characterization of Small Intestinal Submucosa Regenerated Canine Detrusor: Assessment of Reinnervation, in Vitro Compliance and Contractility

The Journal of Urology ◽

10.1016/s0022-5347(01)65761-6 ◽

1996 ◽

Vol 156 (2S) ◽

pp. 599-607 ◽

Cited By ~ 130

Author(s):

Bradley P. Kropp ◽

Barry D. Sawyer ◽

Harlon E. Shannon ◽

Marian K. Rippy ◽

Stephen F. Badylak ◽

...

Keyword(s):

Small Intestinal Submucosa ◽

Small Intestinal ◽

Intestinal Submucosa

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Mechanical Characterization of the Decellularized Porcine Small Intestinal Submucosa Extracellular Matrix

Volume 3A: Biomedical and Biotechnology Engineering ◽

10.1115/imece2013-65640 ◽

2013 ◽

Author(s):

Shijia Zhao ◽

Linxia Gu ◽

James M. Hammel ◽

Haili Lang

Keyword(s):

Mechanical Properties ◽

Extracellular Matrix ◽

Mechanical Response ◽

Mechanical Characterization ◽

Small Intestinal Submucosa ◽

Trade Name ◽

Porcine Small Intestinal Submucosa ◽

Small Intestinal ◽

Intestinal Submucosa

In this work, the decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM), obtained from the commercial product under the trade name of CorMatrix, were tested in uniaxial tension. Preconditioning under cyclic loading of 2 N was conducted to stabilize the mechanical response of the tissue. The influence of rehydration time on the mechanical properties of the tissue was evaluated. Results suggested that the stiffness of SIS-ECM decreased with longer rehydration time. Considering the application of CorMatrix in pericardial closure, the native pericardium samples were also tested. The comparison indicated that the native pericardium is softer than rehydrated CorMatrix. This work can facilitate the surgeons to better choose the appropriate rehydration time when conducting the extracardiac implantations, such as pericardial reconstruction, pericardial closure, etc.

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