The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc

2007 ◽  
pp. 389-392
Author(s):  
Soon Hee Kim ◽  
Bang Sil Choi ◽  
Youn Kyung Ko ◽  
Hyun Jung Ha ◽  
Sun Jung Yoon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

Characterization of Small Intestinal Submucosa Regenerated Canine Detrusor: Assessment of Reinnervation, in Vitro Compliance and Contractility

1996 ◽  
Vol 156 (2S) ◽  
pp. 599-607 ◽  
Author(s):  
Bradley P. Kropp ◽  
Barry D. Sawyer ◽  
Harlon E. Shannon ◽  
Marian K. Rippy ◽  
Stephen F. Badylak ◽  
...  
Keyword(s):  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

Mechanical Characterization of the Decellularized Porcine Small Intestinal Submucosa Extracellular Matrix

2013 ◽  
Author(s):  
Shijia Zhao ◽  
Linxia Gu ◽  
James M. Hammel ◽  
Haili Lang
Keyword(s):  
Mechanical Properties ◽  
Extracellular Matrix ◽  
Mechanical Response ◽  
Mechanical Characterization ◽  
Small Intestinal Submucosa ◽  
Trade Name ◽  
Porcine Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

In this work, the decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM), obtained from the commercial product under the trade name of CorMatrix, were tested in uniaxial tension. Preconditioning under cyclic loading of 2 N was conducted to stabilize the mechanical response of the tissue. The influence of rehydration time on the mechanical properties of the tissue was evaluated. Results suggested that the stiffness of SIS-ECM decreased with longer rehydration time. Considering the application of CorMatrix in pericardial closure, the native pericardium samples were also tested. The comparison indicated that the native pericardium is softer than rehydrated CorMatrix. This work can facilitate the surgeons to better choose the appropriate rehydration time when conducting the extracardiac implantations, such as pericardial reconstruction, pericardial closure, etc.

scholarly journals Small Intestinal Submucosa as a Potential Bioscaffold for Intervertebral Disc Regeneration

Spine ◽  
2006 ◽  
Vol 31 (21) ◽  
pp. 2423-2430 ◽  
Author(s):  
Catherine Le Visage ◽  
Shu-Hua Yang ◽  
Leena Kadakia ◽  
Ann N. Sieber ◽  
John P. Kostuik ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Small Intestinal Submucosa ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration ◽  
Small Intestinal ◽  
Intestinal Submucosa

Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing

2007 ◽  
Vol 342-343 ◽  
pp. 69-72 ◽  
Author(s):  
Min Suk Lee ◽  
In Bum Song ◽  
Gil Son Khang ◽  
Moon Suk Kim ◽  
Hai Bang Lee
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Closure ◽  
Small Intestinal Submucosa ◽  
Natural Polymer ◽  
Rapid Healing ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Injured Skin

To develop a wound dressing that can be removed from the injured skin without the damage and supporting rapid healing, we made hybrid dressing of small intestinal submucosa (SIS) and hydrogels. Alginate and gelatin used as a dressing material in hydrogels were selected to coat SIS sheets. Characteristics and tendency of wound healing of prepared sheets were investigated. Water uptake ability was greater when the sheets were coated with gelatin than alginate although both showed higher water absorption than the native SIS sheets, but the degradation rate of alginate/gelatin coated SIS was slower than that of native SIS because both polymers may delay contact time of enzyme to the SIS surface in solution. It was observed that less of fibroblasts attached to the natural polymer coated SIS sheets. This property will make easy for the detachment of the sheet from the defected tissue. Wound closure examination showed that prepared sheets enhanced wound healing. It was concluded that prepared alginate/gelatin coated SIS sheets are positively regarded as an appropriate biodegradable wound dressing that is reducing patient’s pain during change of the dressing.

Characterization of Small Intestinal Submucosa Regenerated Canine Detrusor

1996 ◽  
pp. 599-607 ◽  
Author(s):  
Bradley P. Kropp ◽  
Barry D. Sawyer ◽  
Harlon E. Shannon ◽  
Marian K. Rippy ◽  
Stephen F. Badylak ◽  
...  
Keyword(s):  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc

2007 ◽  
Vol 342-343 ◽  
pp. 389-392 ◽  
Author(s):  
Soon Hee Kim ◽  
Bang Sil Choi ◽  
Youn Kyung Ko ◽  
Hyun Jung Ha ◽  
Sun Jung Yoon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Solvent Casting ◽  
Small Intestine Submucosa ◽  
Immersion Method ◽  
Salt Leaching ◽  
Freeze Dried ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Hybrid Scaffolds

In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

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