Development of a Therapeutic Device for Osteoporosis

Pulsed electromagnetic fields (PEMF) have been reported as a non-invasive way in the prevention and treatment of osteoporosis. A new PEMF generator was designed to produce more homogeneous magnetic field than normal Helmholtz coils. The intensity and distribution of magnetic field y were calculated theoretically. The results showed that magnetic field generated by improved Helmholtz coils (three identical coils) is more intensive and homogeneous than normal Helmholtz coils (two identical coils). Moreover, this apparatus might play a significant role in the study of biological effects of PEMF on osteoporosis.

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AB0868 EFFICACY AND SAFETY OF PULSED ELECTROMAGNETIC FIELDS IN THE TREATMENT OF OSTEOARTHRITIS: RESULTS OF A MULTICENTER BLIND PLACEBO-CONTROLLED STUDY.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.3973 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1740.2-1740

Author(s):

A. Karateev ◽

E. Pogozheva ◽

M. Sukhareva ◽

A. Lila

Keyword(s):

Magnetic Field ◽

Electromagnetic Fields ◽

Low Frequency ◽

Treatment Result ◽

Controlled Study ◽

Womac Pain ◽

Pulsed Electromagnetic Fields ◽

Group 2 ◽

Pulsed Electromagnetic ◽

Group 1

Background:Pulsed electromagnetic fields (PEMF) is a well – known method of non-pharmacological treatment that is widely used in knee osteoarthritis (KOA).Objectives:To evaluate the effectiveness and safety of PEMF in KOA.Methods:The study group consisted of 231 KOA patients, 77.9% of women, age 61.9±12.2 years, BMI 30.6±5.8 kg / m2, average disease duration 5.0 [2.0;10.0] years. Patients were randomly assigned to two groups. Group 1 patients received PEMF for 14 days using a device that creates a low-frequency pulsed magnetic field, group 2-a false PEMF (a device that completely simulates a working device, but does not create a magnetic field). We evaluated the dynamics of the WOMAC index, the severity of pain at rest and when moving on a 100-mm visual analog scale (VAS), the need for non-steroidal anti-inflammatory drugs (NSAIDs), and the evaluation of the patient’s treatment result (on a 5-point scale).Results:Statistically significant reduction in pain, stiffness, and improved function was observed in both true PEMF and false PEMF. Thus, the WOMAC pain in Group 1 decreased from 231 [180; 290] to 110 [60; 166.3], p<0.001; in Group 2 from 212.4 [145; 260] to 143 [76.5; 200], p<0.001, the severity of pain in rest (VAS) decreased in Group 1 from 47 [27.8; 60] to 20 [10; 30], p<0.001; in Group 2 from 40 [20; 57.5] to 20 [7.5; 40], p<0.001. After therapy, the need for NSAIDs also decreased: in Group 1 NSAIDs were canceled or reduced in 33.1% of patients, in Group 2 - in 16.8% (p=0.006). For all indicators, the dynamics were statistically more significant in Group 1 than in Group 2. The result of treatment as “good” and “excellent” was evaluated by 58.5% of patients in Group 1 and 39.8% of patients in Group 2, p<0.001. No serious adverse reactions were observed when using true and false PEMF. Two patients who received false PEMF therapy was interrupted due to increased joint pain.Conclusion:PEMF with short-term use provides a significant improvement in the condition of KOA patients. PEMF is well tolerated and does not cause serious complications.Disclosure of Interests:None declared

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Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields

Mediators of Inflammation ◽

10.1155/2017/2740963 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 25

Author(s):

Katia Varani ◽

Fabrizio Vincenzi ◽

Annalisa Ravani ◽

Silvia Pasquini ◽

Stefania Merighi ◽

...

Keyword(s):

Electromagnetic Fields ◽

Adenosine Receptors ◽

Biological Effects ◽

Low Frequency ◽

Low Energy ◽

Membrane Receptors ◽

Pulsed Electromagnetic Fields ◽

Inflammatory Status ◽

Anti Inflammatory ◽

Pulsed Electromagnetic

Several studies explored the biological effects of low frequency low energy pulsed electromagnetic fields (PEMFs) on human body reporting different functional changes. Much research activity has focused on the mechanisms of interaction between PEMFs and membrane receptors such as the involvement of adenosine receptors (ARs). In particular, PEMF exposure mediates a significant upregulation ofA2Aand A3ARs expressed in various cells or tissues involving a reduction in most of the proinflammatory cytokines. Of particular interest is the observation that PEMFs, acting as modulators of adenosine, are able to increase the functionality of the endogenous agonist. By reviewing the scientific literature on joint cells, a double role for PEMFs could be hypothesized in vitro by stimulating cell proliferation, colonization of the scaffold, and production of tissue matrix. Another effect could be obtained in vivo after surgical implantation of the construct by favoring the anabolic activities of the implanted cells and surrounding tissues and protecting the construct from the catabolic effects of the inflammatory status. Moreover, a protective involvement of PEMFs on hypoxia damage in neuron-like cells and an anti-inflammatory effect in microglial cells have suggested the hypothesis of a positive impact of this noninvasive biophysical stimulus.

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Effects of Low-Frequency Pulsed Electromagnetic Fields on High-Altitude Stress Ulcer Healing in Rats

BioMed Research International ◽

10.1155/2019/6354054 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

Mingke Jiao ◽

Hong Yin ◽

Jie Hu ◽

Wenjuan Xu ◽

Xiao Zhang ◽

...

Keyword(s):

High Altitude ◽

Electromagnetic Fields ◽

Stress Ulcer ◽

Biological Effects ◽

Low Frequency ◽

Pulsed Electromagnetic Fields ◽

Sprague Dawley ◽

Ph Values ◽

Tissue Healing ◽

Pulsed Electromagnetic

High-altitude stress ulcer (HSU) has constantly been a formidable clinical challenge for high-altitude and severe hypoxia. Pulsed electromagnetic fields (PEMFs) have been verified to have the ability to penetrate tissues, and the biological effects have been confirmed effective on various tissue restorations. However, the therapeutic effect of PEMFs on HSU has been rarely reported. This study aimed to evaluate the effects of PEMFs on HSU healing systematically. Sprague–Dawley rats were assigned to control, HSU, and HSU+PEMF groups. The HSU models were induced by restraint stress under low-pressure hypoxia. The HSU+PEMF group was subjected to PEMF exposure. During the HSU healing, gastric juice pH values, ulcer index (UI), and histopathologic changes were investigated. Furthermore, tumor necrosis factor-α (TNF-α) was determined to analyze the severity of gastric membrane inflammations. Norepinephrine (NE), which influences gastric acid secretion, was measured. Results indicated the UI of the HSU+PEMF decreased faster than that of the HSU group. Histopathologic observation suggested that the ulcer tissue healing is faster in the HSU+PEMF group than in the HSU group. The TNF-α/total protein results revealed that the inflammation of the HSU+PEMF group is suppressed effectively. The pH values are higher in the HSU+PEMF group than in the HSU, as confirmed by NE examination. The results indicated that low-frequency PEMFs can penetrate stomach tissues to relieve the symptoms of HSU and promote the regeneration of disturbed tissues, thus implying the clinical potential of PEMF therapy for HSU treatment.

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