Assessment of Ternary Multicomponent Diffusion in Alloy 22 (Ni-Cr-Mo)

2007 ◽  
Vol 266 ◽  
pp. 181-190 ◽  
Author(s):  
A.V. Jaques ◽  
J.C. LaCombe
Keyword(s):  
Optimization Problem ◽  
Single Phase ◽  
Multicomponent Diffusion ◽  
Diffusion Couples ◽  
Profile Data ◽  
Alloy 22 ◽  
Constant Diffusivity ◽  
Point Composition ◽  
Potential Use

Diffusivity [D] matrices are reported for the ternary Ni-Cr-Mo alloy in the approximate single-phase compositional range of Hastelloy C-22 (Alloy 22), surrounding Ni-63 wt.%, Cr-22.3 wt.%, and Mo-14.7 wt.%. These data will contribute to our understanding of the long-term phase stability of Alloy 22, and its potential use as a corrosion barrier in nuclear waste packages. Experimental diffusion couple data were obtained at selected temperatures from a series of diffusion couples, and evaluated, assuming constant diffusivity. Our approach treats the process as an optimization problem that simultaneously considers concentration profile data from numerous diffusion couples surrounding a single end-point composition. We make use of the mathematical characteristics of the analytical solution to this problem, reducing the number of parameters to be fitted. The parameter fitting is accomplished using a combination of heuristic and deterministic methods. Discussion of the sources and magnitudes of uncertainty in the diffusivity values is included.

Treatment and secondary prevention of venous thromboembolism in cancer patients

2012 ◽  
Vol 03 (03) ◽  
pp. 121-125
Author(s):  
I. Pabinger ◽  
C. Ay
Keyword(s):  
Clinical Trials ◽  
Venous Thromboembolism ◽  
Cancer Patients ◽  
Oral Anticoagulants ◽  
Factor Xa ◽  
New Oral Anticoagulants ◽  
Phase Iii ◽  
Patients With Cancer ◽  
Potential Use

SummaryCancer is a major and independent risk factor of venous thromboembolism (VTE). In clinical practice, a high number of VTE events occurs in patients with cancer, and treatment of cancerassociated VTE differs in several aspects from treatment of VTE in the general population. However, treatment in cancer patients remains a major challenge, as the risk of recurrence of VTE as well as the risk of major bleeding during anticoagulation is substantially higher in patients with cancer than in those without cancer. In several clinical trials, different anticoagulants and regimens have been investigated for treatment of acute VTE and secondary prophylaxis in cancer patients to prevent recurrence. Based on the results of these trials, anticoagulant therapy with low-molecular-weight heparins (LMWH) has become the treatment of choice in cancer patients with acute VTE in the initial period and for extended and long-term anticoagulation for 3-6 months. New oral anticoagulants directly inhibiting thrombin or factor Xa, have been developed in the past decade and studied in large phase III clinical trials. Results from currently completed trials are promising and indicate their potential use for treatment of VTE. However, the role of the new oral thrombin and factor Xa inhibitors for VTE treatment in cancer patients still has to be clarified in further studies specifically focusing on cancer-associated VTE. This brief review will summarize the current strategies of initial and long-term VTE treatment in patients with cancer and discuss the potential use of the new oral anticoagulants.

scholarly journals EcoRacer: Game-Based Optimal Electric Vehicle Design and Driver Control Using Human Players

2016 ◽  
Vol 138 (6) ◽  
Author(s):  
Yi Ren ◽  
Alparslan Emrah Bayrak ◽  
Panos Y. Papalambros
Keyword(s):  
Optimization Problem ◽  
Solution Space ◽  
Efficient Global Optimization ◽  
Vehicle Design ◽  
Control Problems ◽  
Short Term ◽  
Algorithm Efficiency ◽  
Np Complete ◽  
And Control

We compare the performance of human players against that of the efficient global optimization (EGO) algorithm for an NP-complete powertrain design and control problem. Specifically, we cast this optimization problem as an online competition and received 2391 game plays by 124 anonymous players during the first month from launch. We found that while only a small portion of human players can outperform the algorithm in the long term, players tend to formulate good heuristics early on that can be used to constrain the solution space. Such constraining of the search enhances algorithm efficiency, even for different game settings. These findings indicate that human-assisted computational searches are promising in solving comprehensible yet computationally hard optimal design and control problems, when human players can outperform the algorithm in a short term.

Topology Optimization for the Single Phase Flow Using Two Point Flux Approximation Model

2013 ◽  
Author(s):  
Guang Dong ◽  
Yulan Song
Keyword(s):  
Porous Media ◽  
Topology Optimization ◽  
Optimization Problem ◽  
Single Phase ◽  
Flow In Porous Media ◽  
Phase Flow ◽  
Approximation Model ◽  
Single Phase Flow ◽  
Topology Optimization Problem ◽  
Flux Approximation

The topology optimization method is extended to solve a single phase flow in porous media optimization problem based on the Two Point Flux Approximation model. In particular, this paper discusses both strong form and matrix form equations for the flow in porous media. The design variables and design objective are well defined for this topology optimization problem, which is based on the Solid Isotropic Material with Penalization approach. The optimization problem is solved by the Generalized Sequential Approximate Optimization algorithm iteratively. To show the effectiveness of the topology optimization in solving the single phase flow in porous media, the examples of two-dimensional grid cell TPFA model with impermeable regions as constrains are presented in the numerical example section.

Application of Hybrid Biosystems for Stimulation of Oil Production

2021 ◽  
Author(s):  
Baghir Alakbar Suleimanov ◽  
Sabina Jahangir Rzayeva ◽  
Ulviyya Tahir Akhmedova
Keyword(s):  
Oil Recovery ◽  
Single Phase ◽  
Experimental Studies ◽  
Oil Production ◽  
Pore Channel ◽  
Subcritical Region ◽  
Slippage Effect ◽  
Liquid Systems ◽  
Reservoir Conditions

Abstract Microbial enhanced oil recovery is considered to be one of the most promising methods of stimulating formation, contributing to a higher level of oil production from long-term fields. The injection of bioreagents into a reservoir results in the creation of oil-dicing agents along with significant amount of gases, mainly carbon dioxide. In early, the authors failed to study the preparation of self-gasified biosystems and the implementation of the subcritical region (SR) under reservoir conditions. Gasified systems in the subcritical phase have better oil-displacing properties than non-gasified systems. The slippage effect determines the behavior of gas–liquid systems in the SR under reservoir conditions. Slippage occurs more easily when the pore channel has a smaller average radius. Therefore, in a heterogeneous porous medium, the filtration profile of gasified liquids in the SR should be more uniform than for a degassed liquid. The theoretical and practical foundations for the preparation of single-phase self-gasified biosystems and the implementation of the SR under reservoir conditions have been developedSR under reservoir conditions. Based on experimental studies, the superior efficiency of oil displacement by gasified biosystems compared with degassed ones has been demonstrated. The possibility of efficient use of gasified hybrid biopolymer systems has been shown.

Interface Movement and Microstructure Evolution of Interdiffusion in the Binary Alloy Diffusion Couples

2011 ◽  
Vol 689 ◽  
pp. 123-129
Author(s):  
Yong Sheng Li ◽  
Yan Zhou Yu ◽  
Xiao Lin Cheng ◽  
Guang Chen
Keyword(s):  
Single Phase ◽  
Relative Concentration ◽  
Equilibrium Concentration ◽  
Diffusion Couples ◽  
Binary Diffusion ◽  
Two Phase ◽  
Concentration Difference ◽  
Initial Concentration ◽  
Interdiffusion Flux ◽  
Interface Movement

The phase field simulation of interface movement and interdiffusion microstructure in a binary diffusion couples was developed. The diffusion couples with nonequilibrium concentration for single phase or single phase and two-phase including the temperature and mobility effects were studied. It’s shown that the interface movement and the atoms diffusion direction were determined by the magnitude of relative concentration difference between the initial concentration and the equilibrium concentration, the distance of interface movement and interdiffusion flux increases as the temperature or the mobility increasing, and the large mobility makes the particles coarsening faster.

Treatment and secondary prevention of venous thrombo -embolism in cancer patients

2012 ◽  
Vol 32 (02) ◽  
pp. 139-144 ◽  
Author(s):  
I. Pabinger ◽  
C. Ay
Keyword(s):  
Clinical Trials ◽  
Cancer Patients ◽  
Oral Anticoagulants ◽  
Initial Period ◽  
Factor Xa ◽  
Secondary Prophylaxis ◽  
Phase Iii ◽  
Patients With Cancer ◽  
Potential Use

SummaryCancer is a major and independent risk factor of venous thromboembolism (VTE). In clinical practice, a high number of VTE events occurs in patients with cancer, and treatment of cancer-associated VTE differs in several aspects from treatment of VTE in the general population. However, treatment in cancer patients remains a major challenge, as the risk of recurrence of VTE as well as the risk of major bleeding during anticoagulation is substantially higher in patients with cancer than in those without cancer. In several clinical trials, different anticoagulants and regimens have been investigated for treatment of acute VTE and secondary prophylaxis in cancer patients to prevent recurrence. Based on the results of these trials, anticoagulant therapy with low-molecular-weight heparins (LMWH) has become the treatment of choice in cancer patients with acute VTE in the initial period and for extended and long-term anticoagulation for 3–6 months. New oral anti-coagulants directly inhibiting thrombin or factor Xa, have been developed in the past decade and studied in large phase III clinical trials. Results from currently completed trials are promising and indicate their potential use for treatment of VTE also in cancer patients. However, the role of the new oral thrombin and factor Xa inhibitors for VTE treatment in cancer patients still has to be clarified in further studies specifically focusing on cancer-associated VTE. This brief review will summarize the current strategies of initial and long-term VTE treatment in patients with cancer and discuss the potential use of the new oral anticoagulants.

scholarly journals A trajectory design method for RLV via artificialmemory-principle optimization

2018 ◽  
Vol 189 ◽  
pp. 10019
Author(s):  
Hao Li ◽  
Changzhu Wei
Keyword(s):  
Trajectory Optimization ◽  
Optimization Problem ◽  
Optimization Problems ◽  
Memory Cell ◽  
Optimization Method ◽  
Alternative Solution ◽  
Trajectory Design ◽  
Memory State ◽  
Artificial Memory

A trajectory optimization method for RLV based on artificial memory principles is proposed. Firstly the optimization problem is modelled in Euclidean space. Then in order to solve the complicated optimization problem of RLV in entry phase, Artificial-memory-principle optimization (AMPO) is introduced. AMPO is inspired by memory principles, in which a memory cell consists the whole information of an alternative solution. The information includes solution state and memory state. The former is an evolutional alternative solution, the latter indicates the state type of memory cell: temporary, short-and long-term. In the evolution of optimization, AMPO makes a various search (stimulus) to ensure adaptability, if the stimulus is good, memory state will turn temporary to short-term, even long-term, otherwise it not. Finally, simulation of different methods is carried out respectively. Results show that the method based on AMPO has better performance and high convergence speed when solving complicated optimization problems of RLV.

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