Study on Anti-Tumor Activity of Novel 3-Substituted 4 Anilino-Coumarin Derivatives Using Quantitative Structure-Activity Relationship (QSAR)
2019 ◽
Vol 948
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pp. 101-108
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Keyword(s):
Study on anti breast cancer activity of 3-substituted 4-anilino coumarin derivatives by using quantitative structure-activity relationship (QSAR) has been performed. The structures and the activity data were literatured from Guoshun et al. experiment. The molecular and electronic molecule properties were obtained from DFT/BPV86 6-31G method calculation after was through methods validation. The QSAR analysis were shown by Multi Linear Regression method (MLR). The best model of obtained for 3-substituted 4-anilino coumarin derivatives is: Log IC50 = 5.905 + (0.936 x qC1) + (-8.225 x qC8) + (-0.582 x qC13) + (11.273 x qC15) + (0.869 x ∆E) ; n = 26; r2= 0.704; Fcal/Ftab = 2.462; SEE = 0.184.
2010 ◽
Vol 150
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pp. 60-60
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1995 ◽
pp. 354-374
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2003 ◽
Vol 55
(4)
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pp. 505-511
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1999 ◽
Vol 64
(5)
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pp. 527-544
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