Neonatal and Pediatric Parenteral Nutrition

2012 ◽  
Vol 23 (4) ◽  
pp. 451-464 ◽  
Author(s):  
Anne Gargasz
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Pediatric Patients ◽  
Intestinal Failure ◽  
Nutritional Requirements ◽  
Gastrointestinal Fistula ◽  
Short Bowel ◽  
Therapeutic Modalities ◽  
The 1960S

Parenteral nutrition is one of the most important therapeutic modalities invented in the last several decades. Since its introduction in the 1960s, this modality has saved thousands of lives by providing nutrients parenterally to sustain growth in premature neonates with severe intestinal immaturity and other pediatric patients with intestinal failure, such as a gastrointestinal fistula or short bowel syndrome. Although parenteral nutrition can be a lifesaving treatment, it is not benign. Many complications can result from either short- or long-term usage. This review discusses the nutritional requirements, common complications, medication additives, and special considerations for pediatric patients requiring parenteral nutrition.

scholarly journals Short bowel syndrome in infancy: recent advances and practical management

2020 ◽  
pp. flgastro-2020-101457
Author(s):  
Elena Cernat ◽  
Chloe Corlett ◽  
Natalia Iglesias ◽  
Nkem Onyeador ◽  
Julie Steele ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Intestinal Adaptation ◽  
Intestinal Failure ◽  
Rare Condition ◽  
Oral Feeding ◽  
Short Bowel ◽  
Intestinal Continuity ◽  
Gastrointestinal Reconstruction ◽  
Lipid Reduction

Short bowel syndrome (SBS) is a rare condition characterised by extensive loss of intestinal mass secondary to congenital or acquired disease. The outcomes are determined by dependency on parenteral nutrition (PN), its possible complications and factors that influence intestinal adaptation. In order to achieve the best results, patients should be managed by a specialised multidisciplinary team with the aims of promoting growth and development, stimulating intestinal adaptation and preventing possible complications. This involves timely surgical management aimed at rescuing maximum bowel length and eventually re-establishing intestinal continuity where appropriate. A combination of enteral and parenteral nutrition needs to be targeted towards maintaining a balance between fulfilling the nutritional and metabolic needs of the child while preventing or at least minimising potential complications. Enteral nutrition and establishment of oral feeding play a fundamental role in stimulating bowel adaptation and promoting enteral autonomy. Other measures to promote enteral autonomy include the chyme recycling in patients where bowel is not in continuity, autologous gastrointestinal reconstruction and pharmacological treatments, including promising new therapies like teduglutide. Strategies such as lipid reduction, changing the type of lipid emulsion and cycling PN are associated with a reduction in the rates of intestinal failure–associated liver disease. Even though vast improvements have been made in the surgical and medical management of SBS, there is still lack of consensus in many aspects and collaboration is essential.

scholarly journals Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure due to Short Bowel Syndrome: A 24‐Week, Phase III Study

2019 ◽  
Vol 44 (4) ◽  
pp. 621-631 ◽  
Author(s):  
Samuel A. Kocoshis ◽  
Russell J. Merritt ◽  
Susan Hill ◽  
Susan Protheroe ◽  
Beth A. Carter ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Pediatric Patients ◽  
Intestinal Failure ◽  
Phase Iii ◽  
Safety And Efficacy ◽  
Short Bowel ◽  
Phase Iii Study

Long term outcomes of intestinal rehabilitation in children with neonatal very short bowel syndrome: Parenteral nutrition or intestinal transplantation

2019 ◽  
Vol 38 (2) ◽  
pp. 926-933 ◽  
Author(s):  
Lorenzo Norsa ◽  
Solene Artru ◽  
Cecile Lambe ◽  
Cecile Talbotec ◽  
Benedicte Pigneur ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Intestinal Transplantation ◽  
Long Term Outcomes ◽  
Short Bowel ◽  
Intestinal Rehabilitation

Long-Term Outcome of Home Parenteral Nutrition in Patients With Ultra-Short Bowel Syndrome

2014 ◽  
Vol 58 (4) ◽  
pp. 438-442 ◽  
Author(s):  
Antonella Diamanti ◽  
Andrea Conforti ◽  
Fabio Panetta ◽  
Giuliano Torre ◽  
Manila Candusso ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Home Parenteral Nutrition ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Short Bowel

Bowel rehabilitation: an alternative to long-term parenteral nutrition and intestinal transplantation for some patients with short bowel syndrome

2002 ◽  
Vol 34 (3) ◽  
pp. 887-890 ◽  
Author(s):  
T.A. Byrne ◽  
S. Cox ◽  
M. Karimbakas ◽  
L.M. Veglia ◽  
H.M. Bennett ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Intestinal Transplantation ◽  
Short Bowel

PP102-MON: Long-Term Safety and Efficacy with Teduglutide Treatment in Patients with Intestinal Failure Associated with Short Bowel Syndrome (SBS–IF): The Steps-3 Study

2014 ◽  
Vol 33 ◽  
pp. S167-S168 ◽  
Author(s):  
K. Iyer ◽  
K. Fujioka ◽  
J.I. Boullata ◽  
T.R. Ziegler ◽  
N.N. Youssef ◽  
...  
Keyword(s):  
Short Bowel Syndrome ◽  
Intestinal Failure ◽  
Safety And Efficacy ◽  
Short Bowel
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