scholarly journals Two cases of paediatric autoimmune neuropsychiatric disorder associated with group A beta haemolytic streptococcal infection

2010 ◽  
Vol 39 (1) ◽  
pp. 29
Author(s):  
Hemamali Perera ◽  
Malika Weerasinghe ◽  
Geetha M Sathiadas
Keyword(s):  
Streptococcal Infection ◽  
Neuropsychiatric Disorder ◽  
Group A

scholarly journals Paediatric Autoimmune Neuropsychiatric Disorder Associated with Group A Beta-Haemolytic Streptococcal Infection: An Indication for Tonsillectomy? A Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Amarkumar Dhirajlal Rajgor ◽  
Navid Akhtar Hakim ◽  
Sanah Ali ◽  
Adnan Darr
Keyword(s):  
Streptococcal Infection ◽  
Group A Streptococcus ◽  
Case Reports ◽  
Neuropsychiatric Symptoms ◽  
Case Series ◽  
Acute Onset ◽  
Neuropsychiatric Disorder ◽  
Inclusion Criteria ◽  
Definitive Evidence ◽  
Group A

Background. Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS) is the acute onset of neuropsychiatric symptoms following group A beta-haemolytic streptococcal infection. The aetiology remains elusive. However, with group A streptococcus being the most common bacterial cause of tonsillitis, surgical intervention in the form of tonsillectomy has often been considered as a potential therapy. Methods. A MEDLINE® search was undertaken using keywords “PANDAS” or “paediatric autoimmune neuropsychiatric disorders associated with streptococcus” combined with “tonsillectomy”. Results. Six case reports and 3 case series met the inclusion criteria. Demesh et al. (case series) reported a dramatic reduction in neuropsychiatric symptom severity in the patient cohort undergoing tonsillectomy. Two case series suggest that there is no association between tonsillectomy and resolution of PANDAS. Conclusion. Due to the lack of uniform data and sporadic reports, tonsillectomy should be carefully adopted for the treatment of this disorder. In particular, tonsillectomies/adenoidectomies to alleviate neuropsychiatric symptoms should be avoided until more definitive evidence is at our disposal. This review highlights the importance of a potential collaborative prospective study.

scholarly journals Immune deficiency derive a favorable response to IVIg in PANDAS

2018 ◽  
Vol 2 (3) ◽  
pp. 01-03
Author(s):  
Eric Arthur Blair
Keyword(s):  
Immune Deficiency ◽  
Immune Globulin ◽  
Streptococcal Infection ◽  
Ivig Therapy ◽  
Neuropsychiatric Disorder ◽  
Intravenous Immune Globulin ◽  
High Dose ◽  
Group A ◽  
Post Infectious

For two decades, pediatric autoimmune neuropsychiatric disorder associated with group a beta hemolytic streptococcal infection (PANDAS) has been treated with high-dose intravenous immune globulin (IVIg) therapy based upon the understanding that the disorder is partly due to post-infectious dysimmunity.

scholarly journals LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection

Cell Reports ◽  
2021 ◽  
Vol 34 (9) ◽  
pp. 108766
Author(s):  
Debabrata Biswas ◽  
Poornima Ambalavanan ◽  
Miriam Ravins ◽  
Aparna Anand ◽  
Abhinay Sharma ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Group A

Invasive group A streptococcal infection in pregnancy

2010 ◽  
Vol 60 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Takahiro Yamada ◽  
Takashi Yamada ◽  
Mie K. Yamamura ◽  
Kenichi Katabami ◽  
Mineji Hayakawa ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A ◽  
In Pregnancy

Group A β-Hemolytic Streptococcal Balanitis: It May Be More Common Than You Think

PEDIATRICS ◽  
1991 ◽  
Vol 88 (1) ◽  
pp. 154-156
Author(s):  
NICHOLAS C. KYRIAZI ◽  
CYNTHIA L. COSTENBADER
Keyword(s):  
Sexual Abuse ◽  
Streptococcal Infection ◽  
Hemolytic Streptococcus ◽  
Depth Study ◽  
Group A

Group A β-hemolytic Streptococcus can cause balanitis in prepubertal males, and its incidence is probably greater than previously reported in the pediatric literature. We suggest the routine inclusion of a GABHS-selective culture in any case where a discharge or irritation is present on the glans or foreskin, especially if a recent streptococcal infection has been documented, whether on not sexual abuse is being considered. Finally, we hope to stimulate interest for further in-depth study of balanitis caused by GABHS.

COMMENTS ON DR. KLEIN'S PAPER

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 390-390
Keyword(s):  
Air Force ◽  
Streptococcal Infection ◽  
Staphylococcal Infection ◽  
Klein Group ◽  
Significant Difference ◽  
Group A ◽  
Air Force Base ◽  
Group B ◽  
Antibiotic Ointment ◽  
Boston Hospital

Dr. Ribble: In this study was the umbilicus included in bathing of the "diaper area"? Dr. Klein: Yes. Dr. Ribble: Have epidemics of streptococcal disease occured in nurseries in which hexachlorophene bathing was being carried out? Dr. Klein: Group B beta hemolytic streptococcal infections have been reported in nurseries where hexachlorophene bathing was being used. Dr. Schaberg: We have had cultural evidence of the presence of Group A streptococcal infection in infants on hexachlorophene bathing, and another Boston hospital had a nursery epidemic of Group A streptococcal infection in 1967 while using hexachlorophene bathing. Dr. Gezon: Mortimer also reported an epidemic occurring in a nursery where only the babies' faces were washed with hexachlorophene. Leadbetter's data from Lackland Air Force Base showed that he was unable to stop an epidemic of staphylococcal infection with intensive hexachlorophene bathing, including washing the umbilicus three times a day with hexachlorophene. He was also unable to get a significant difference in colonization rates when half the infants were washed with hexachlorophene and half were not. Dr. Gezon: Attention to the umbilicus is very important in controlling staphylococcal infection in the newborn. Jellard has shown this with triple dye, Gillespie with hexachlorophene powder, and Mortimer with antibiotic ointment applied to the umbilicus.

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