scholarly journals Early CD4+T Cell Help Prevents Partial CD8+T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency

2009 ◽  
Vol 184 (1) ◽  
pp. 277-286 ◽  
Author(s):  
Gregory M. Frank ◽  
Andrew J. Lepisto ◽  
Michael L. Freeman ◽  
Brian S. Sheridan ◽  
Thomas L. Cherpes ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Herpes Simplex Virus 1 ◽  
Cell Exhaustion ◽  
Simplex Virus ◽  
T Cell Help

scholarly journals Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection

2020 ◽  
Vol 205 (2) ◽  
pp. 454-468
Author(s):  
Pierre-Grégoire Coulon ◽  
Soumyabrata Roy ◽  
Swayam Prakash ◽  
Ruchi Srivastava ◽  
Nisha Dhanushkodi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
Cell Exhaustion ◽  
Ocular Herpes ◽  
Simplex Virus

scholarly journals CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Cell Reports ◽  
2021 ◽  
Vol 36 (11) ◽  
pp. 109696
Author(s):  
Yu-Jung Lu ◽  
Palmira Barreira-Silva ◽  
Shayla Boyce ◽  
Jennifer Powers ◽  
Kelly Cavallo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cell ◽  
Tuberculosis Infection ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Mycobacterium Tuberculosis Infection ◽  
Cell Exhaustion ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice

2010 ◽  
Vol 84 (23) ◽  
pp. 12315-12324 ◽  
Author(s):  
Sariah J. Allen ◽  
Kevin R. Mott ◽  
Mandana Zandian ◽  
Homayon Ghiasi
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACT We have shown previously that immunization with herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) exacerbated corneal scarring (CS) in ocularly infected mice. In this study, we investigated whether higher levels of CS were correlated with higher levels of latency and T cell exhaustion in gK-immunized mice. BALB/c mice were vaccinated with baculovirus-expressed gK or gD or mock immunized. Twenty-one days after the third immunization, mice were ocularly infected with 2 × 104 PFU/eye of virulent HSV-1 strain McKrae. On day 5 postinfection, virus replication in the eye was measured, and on day 30 postinfection, infiltration of the trigeminal ganglia (TG) by CD4, CD8, programmed death 1 (PD-1), and T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) was monitored by immunohistochemistry and quantitative real-time PCR (qRT-PCR). This study demonstrated that higher levels of CS were correlated with higher levels of latency, and this was associated with the presence of significantly higher numbers of CD4+PD-1+ and CD8+PD-1+ cells in the TG of the gK-immunized group than in both the gD- and mock-immunized groups. Levels of exhaustion associated with Tim-3 were the same among gK- and mock-vaccinated groups but higher than levels in the gD-vaccinated group. In this study, we have shown for the first time that both PD-1 and Tim-3 contribute to T cell exhaustion and an increase of latency in the TG of latently infected mice.

CD4 T Cell Help Prevents CD8 T Cell Exhaustion and Promotes Control of  Mycobacterium tuberculosis Infection

2021 ◽  
Author(s):  
Yu-Jung Wu ◽  
Palmira Barreira-Silva ◽  
Shayla Boyce ◽  
Jennifer Powers ◽  
Cavallo Kelly ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Cd4 T Cell Help ◽  
T Cell Help
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