scholarly journals STAT5-Induced Lunatic Fringe during Th2 Development Alters Delta-like 4–Mediated Th2 Cytokine Production in Respiratory Syncytial Virus–Exacerbated Airway Allergic Disease

2013 ◽  
Vol 192 (3) ◽  
pp. 996-1003 ◽  
Author(s):  
Sumanta Mukherjee ◽  
Andrew J. Rasky ◽  
Phil A. Lundy ◽  
Nicolai A. Kittan ◽  
Steven L. Kunkel ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Allergic Disease ◽  
Cytokine Production ◽  
Lunatic Fringe ◽  
Th2 Cytokine ◽  
Syncytial Virus ◽  
Th2 Development

Respiratory syncytial-virus induced cytokine production from leukocytes is impaired in severe asthma

2021 ◽  
Author(s):  
Kaschin Jamal Jameel ◽  
Sarah Yanik ◽  
Eike Bülthoff ◽  
Simon Rohde ◽  
Daniel Weidinger ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Severe Asthma ◽  
Cytokine Production ◽  
Syncytial Virus

scholarly journals Role of CCL11 in Eosinophilic Lung Disease during Respiratory Syncytial Virus Infection

2005 ◽  
Vol 79 (4) ◽  
pp. 2050-2057 ◽  
Author(s):  
Stephen P. Matthews ◽  
John S. Tregoning ◽  
Anthony J. Coyle ◽  
Tracy Hussell ◽  
Peter J. M. Openshaw
Keyword(s):  
Respiratory Syncytial Virus ◽  
Cytokine Production ◽  
The Elderly ◽  
Viral Pathogen ◽  
Blocking Antibody ◽  
Interleukin 5 ◽  
Lung Eosinophilia ◽  
Syncytial Virus

ABSTRACT Respiratory syncytial virus (RSV) is a major viral pathogen of infants and the elderly. Significant morbidity is caused by an overexuberant mixed lung cell infiltrate, which is thought to be driven by chemokines. One of the main chemotactic mediators responsible for the movement of eosinophils is CCL11 (eotaxin). Using a mouse model of eosinophilic bronchiolitis induced by RSV, we show here that treatment in vivo with a blocking antibody to CCL11 greatly reduces lung eosinophilia and disease severity. In addition, anti-CCL11 caused a striking inhibition of CD4-T-cell influx and shifted cytokine production away from interleukin-5 without reducing the resistance to viral replication. These results suggest that in addition to influencing eosinophil diapedesis and survival, anti-CCL11 has an action on T cells. These studies strengthen the case for anti-CCL11 treatment of Th2-driven diseases.

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