scholarly journals IL-12 Administration Accelerates Autoimmune Diabetes in Both Wild-Type and IFN-γ-Deficient Nonobese Diabetic Mice, Revealing Pathogenic and Protective Effects of IL-12-Induced IFN-γ

2003 ◽  
Vol 170 (11) ◽  
pp. 5491-5501 ◽  
Author(s):  
Sylvie Trembleau ◽  
Giuseppe Penna ◽  
Silvia Gregori ◽  
Nadia Giarratana ◽  
Luciano Adorini
Keyword(s):  
Autoimmune Diabetes ◽  
Protective Effects ◽  
Diabetic Mice ◽  
Wild Type ◽  
Nonobese Diabetic ◽  
Ifn Γ ◽  
Nonobese Diabetic Mice

Long-Term Metabolic Control of Autoimmune Diabetes in Spontaneously Diabetic Nonobese Diabetic Mice by Nonvascularized Microencapsulated Adult Porcine Islets

2009 ◽  
Vol 88 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Hong Cui ◽  
Carol Tucker-Burden ◽  
Sean M. D. Cauffiel ◽  
Adrienne K. Barry ◽  
Neal N. Iwakoshi ◽  
...  
Keyword(s):  
Metabolic Control ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Porcine Islets ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Adenovirus Early Region 3 Transgenes Expressed in β Cells Prevent Autoimmune Diabetes in Nonobese Diabetic Mice: Effects of Deleting the Adenovirus Death Protein 11.6K

2005 ◽  
Vol 79 (1) ◽  
pp. 619-621 ◽  
Author(s):  
Melissa A. Pierce ◽  
Anton Svetlanov ◽  
Marshall S. Horwitz ◽  
David V. Serreze
Keyword(s):  
Autoimmune Diabetes ◽  
Gene Cassette ◽  
Diabetic Mice ◽  
Β Cells ◽  
Early Region ◽  
Nonobese Diabetic ◽  
Proapoptotic Protein ◽  
Nonobese Diabetic Mice ◽  
Early Region 3

ABSTRACT The incidence of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette of adenovirus early region 3 (E3) immunomodulating genes in pancreatic β cells. Embedded among the antiapoptotic E3 genes is one encoding an adenovirus death protein (ADP), which contributes to release of virion particles by promoting cell lysis. Because removal of this proapoptotic protein might have further enhanced the ability of E3 proteins to prevent T1D, an ADP-inactivated E3 construct was tested. Significantly, deletion of ADP did not improve the diabetes-protective effect of an E3 gene cassette.

scholarly journals Transgenic Expression of Decoy Receptor 3 Protects Islets from Spontaneous and Chemical-induced Autoimmune Destruction in Nonobese Diabetic Mice

2004 ◽  
Vol 199 (8) ◽  
pp. 1143-1151 ◽  
Author(s):  
Hsiang-Hsuan Sung ◽  
Jyuhn-Huarng Juang ◽  
Yu-Chun Lin ◽  
Chien-Hung Kuo ◽  
Jung-Tung Hung ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Dependent Manner ◽  
Diabetic Mice ◽  
Decoy Receptor ◽  
Nonobese Diabetic ◽  
Decoy Receptor 3 ◽  
Nonobese Diabetic Mice ◽  
Islet Transplants

Decoy receptor 3 (DCR3) halts both Fas ligand– and LIGHT-induced cell deaths, which are required for pancreatic β cell damage in autoimmune diabetes. To directly investigate the therapeutic potential of DCR3 in preventing this disease, we generated transgenic nonobese diabetic mice, which overexpressed DCR3 in β cells. Transgenic DCR3 protected mice from autoimmune and cyclophosphamide-induced diabetes in a dose-dependent manner and significantly reduced the severity of insulitis. Local expression of the transgene did not alter the diabetogenic properties of systemic lymphocytes or the development of T helper 1 or T regulatory cells. The transgenic islets had a higher transplantation success rate and survived for longer than wild-type islets. We have demonstrated for the first time that the immune-evasion function of DCR3 inhibits autoimmunity and that genetic manipulation of grafts may improve the success and survival of islet transplants.

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 ◽  
Vol 4 (4) ◽  
pp. 404-409 ◽  
Author(s):  
S. Ghosh ◽  
S.M. Palmer ◽  
N.R. Rodrigues ◽  
H.J. Cordell ◽  
C.M. Hearne ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Polygenic Control ◽  
Nonobese Diabetic Mice

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes

2014 ◽  
Vol 147 (1) ◽  
pp. 162-171.e6 ◽  
Author(s):  
Majid Mojibian ◽  
Ada W.Y. Lam ◽  
Yukihiro Fujita ◽  
Ali Asadi ◽  
Guntram A. Grassl ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
K Cells ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice
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