scholarly journals Chemokine Receptor CCR2 but Not CCR5 or CCR6 Mediates the Increase in Pulmonary Dendritic Cells during Allergic Airway Inflammation

2007 ◽  
Vol 178 (8) ◽  
pp. 5305-5311 ◽  
Author(s):  
Lander J. Robays ◽  
Tania Maes ◽  
Serge Lebecque ◽  
Sergio A. Lira ◽  
William A. Kuziel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Chemokine Receptor ◽  
Allergic Airway Inflammation ◽  
Chemokine Receptor Ccr2

scholarly journals Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation

2013 ◽  
Vol 288 (23) ◽  
pp. 16262-16273 ◽  
Author(s):  
Keqiang Chen ◽  
Mingyong Liu ◽  
Ying Liu ◽  
Chunyan Wang ◽  
Teizo Yoshimura ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Chemokine Receptor ◽  
Allergic Airway Inflammation ◽  
Leukocyte Accumulation ◽  
Signal Relay ◽  
Cc Chemokine Receptor 2 ◽  
Chemokine Receptor Ccr2 ◽  
Formylpeptide Receptor

Chemoattractant receptors regulate leukocyte accumulation at sites of inflammation. In allergic airway inflammation, although a chemokine receptor CCR2 was implicated in mediating monocyte-derived dendritic cell (DC) recruitment into the lung, we previously also discovered reduced accumulation of DCs in the inflamed lung in mice deficient in formylpeptide receptor Fpr2 (Fpr2−/−). We therefore investigated the role of Fpr2 in the trafficking of monocyte-derived DCs in allergic airway inflammation in cooperation with CCR2. We report that in allergic airway inflammation, CCR2 mediated the recruitment of monocyte-derived DCs to the perivascular region, and Fpr2 was required for further migration of the cells into the bronchiolar area. We additionally found that the bronchoalveolar lavage liquid from mice with airway inflammation contained both the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP. Furthermore, similar to Fpr2−/− mice, in the inflamed airway of CRAMP−/− mice, DC trafficking into the peribronchiolar areas was diminished. Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking of DCs within the inflamed lung.

Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells

Allergy ◽  
2015 ◽  
Vol 70 (8) ◽  
pp. 921-932 ◽  
Author(s):  
J. Dong ◽  
C. K. Wong ◽  
Z. Cai ◽  
D. Jiao ◽  
M. Chu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Inflammatory Dendritic Cells

scholarly journals Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation

2018 ◽  
Vol 9 ◽  
Author(s):  
Ekaterina O. Gubernatorova ◽  
Ekaterina A. Gorshkova ◽  
Olga A. Namakanova ◽  
Ruslan V. Zvartsev ◽  
Juan Hidalgo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Redundant Functions

scholarly journals β2 adrenergic agonist attenuates house dust mite-induced allergic airway inflammation through dendritic cells

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Go Kato ◽  
Koichiro Takahashi ◽  
Hiroki Tashiro ◽  
Keigo Kurata ◽  
Hideharu Shirai ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Airway Inflammation ◽  
Adrenergic Agonist ◽  
Dust Mite

scholarly journals Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma

2010 ◽  
Vol 161 (7) ◽  
pp. 1496-1511 ◽  
Author(s):  
Chen-Chen Lee ◽  
Chien-Neng Wang ◽  
Yu-Ting Lai ◽  
Jaw-Jou Kang ◽  
Jiunn-Wang Liao ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Airway Inflammation ◽  
Murine Model ◽  
Allergic Airway Inflammation

scholarly journals Concomitant Inhalation of Cigarette Smoke and Aerosolized Protein Activates Airway Dendritic Cells and Induces Allergic Airway Inflammation in a TLR-Independent Way

2009 ◽  
Vol 183 (4) ◽  
pp. 2758-2766 ◽  
Author(s):  
Lander J. Robays ◽  
Ellen A. Lanckacker ◽  
Katrien B. Moerloose ◽  
Tania Maes ◽  
Ken R. Bracke ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Cigarette Smoke ◽  
Allergic Airway Inflammation

scholarly journals Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells

2017 ◽  
Vol 139 (2) ◽  
pp. 655-666.e7 ◽  
Author(s):  
Yashaswini Kannan ◽  
Yanda Li ◽  
Stephanie M. Coomes ◽  
Isobel S. Okoye ◽  
Victoria S. Pelly ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Progression ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation
Sign in / Sign up

Export Citation Format

Share Document