scholarly journals The Use of Auditory Event-Related Potentials in Alzheimer's Disease Diagnosis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Fabrizio Vecchio ◽  
Sara Määttä
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Event Related Potentials ◽  
Disease Diagnosis ◽  
Strategic Role ◽  
Diagnosis Of Dementia ◽  
Related Potentials ◽  
Dementing Illness ◽  
Early Alzheimer’S Disease ◽  
Auditory Event Related Potentials

Event-related potentials (ERPs) are important clinical and research instruments in neuropsychiatry, particularly due to their strategic role for the investigation of brain function. These techniques are often underutilized in the evaluation of neurological and psychiatric disorders, but ERPs are noninvasive instruments that directly reflect cortical neuronal activity. Previous studies using the P300, P3a, and MMN components of the ERP to study dementing illness are reviewed. The results suggest that particularly the P300 brain potential is sensitive to Alzheimer's disease processes during its early stages, and that easily performed stimulus discrimination tasks are the clinically most useful. Finally, these data suggest that the P300 ERP can aid in the diagnosis of dementia and may help in the assessment of early Alzheimer's disease.

Auditory Event-related Potentials in Mild Cognitive Impairment and Alzheimer’s Disease

2018 ◽  
Vol 15 (8) ◽  
pp. 702-715 ◽  
Author(s):  
Cassandra Morrison ◽  
Sheida Rabipour ◽  
Frank Knoefel ◽  
Christine Sheppard ◽  
Vanessa Taler
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Aging ◽  
Event Related Potentials ◽  
Cognitive Changes ◽  
Auditory Event ◽  
Related Potentials ◽  
Auditory Event Related Potentials

Background: Mild cognitive deficits are more likely to occur with increasing age, and become more pronounced for people diagnosed with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Conventional methods to identify cognitive declines (i.e., neuropsychological testing and clinical judgment) can lead to false positive diagnoses of cognitive impairment. Tools such as electroencephalography (EEG) offer additional measures of cognitive processing, indexing the electrophysiological changes associated with aging, MCI and AD. Objective: We reviewed the literature on EEG to determine if auditory event-related potentials (ERPs) could distinguish between healthy aging, MCI, and AD. Method: We searched two electronic databases (Medline and PyscInfo) for articles published between January 2005 and April 2017. Articles were considered for review if they included: i) participants 60 years of age or older; ii) healthy older adults or those diagnosed with MCI or AD; iii) at least one auditory elicited ERP component. Results: Our search revealed 1532 articles (800 after removing duplicates); 719 were excluded through title/abstract review, and of the 81 remaining articles, 30 satisfied inclusion criteria. All studies compared cognitive function between at least two of the three selected populations. Our findings suggest that the P300 and N200 components may distinguish between healthy cognitive aging, MCI, and AD. Conclusion: ERPs may be sensitive to progressive cognitive changes due to MCI and AD. The P300 and N200 may help identify patients who are likely to progress from MCI to AD, and could be a valuable clinical tool.

P2-176: Are cortical sources of auditory oddball event-related potentials an early diagnostic marker of Alzheimer's disease?

2015 ◽  
Vol 11 (7S_Part_12) ◽  
pp. P559-P559
Author(s):  
Claudio Babiloni ◽  
Claudio Del Percio ◽  
Nicola Marzano ◽  
Susanna Cordone ◽  
Giuseppe Noce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Marker ◽  
Event Related Potentials ◽  
Auditory Oddball ◽  
Cortical Sources ◽  
Related Potentials ◽  
Early Diagnostic
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