scholarly journals Peripheral Artery Disease: Current Insight Into the Disease and Its Diagnosis and Management

2010 ◽  
Vol 85 (7) ◽  
pp. 678-692 ◽  
Author(s):  
Jeffrey W. Olin ◽  
Brett A. Sealove
2018 ◽  
Vol 10 (1) ◽  
pp. 18-33 ◽  
Author(s):  
Lindsay E. Clegg ◽  
Feilim Mac Gabhann

We used a multiscale systems pharmacology model to provide insight into the mechanisms of action of several classes of pro-angiogenic therapies.


2019 ◽  
Vol 8 (9) ◽  
pp. 1463 ◽  
Author(s):  
Ahmed Ismaeel ◽  
Marco E. Franco ◽  
Ramon Lavado ◽  
Evlampia Papoutsi ◽  
George P. Casale ◽  
...  

Peripheral artery disease (PAD) is a common atherosclerotic disease characterized by narrowed or blocked arteries in the lower extremities. Circulating serum biomarkers can provide significant insight regarding the disease progression. Here, we explore the metabolomics signatures associated with different stages of PAD and investigate potential mechanisms of the disease. We compared the serum metabolites of a cohort of 26 PAD patients presenting with claudication and 26 PAD patients presenting with critical limb ischemia (CLI) to those of 26 non-PAD controls. A difference between the metabolite profiles of PAD patients from non-PAD controls was observed for several amino acids, acylcarnitines, ceramides, and cholesteryl esters. Furthermore, our data demonstrate that patients with CLI possess an altered metabolomic signature different from that of both claudicants and non-PAD controls. These findings provide new insight into the pathophysiology of PAD and may help develop future diagnostic procedures and therapies for PAD patients.


VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.


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