Bioethical aspects of basic research and medical applications of human stem cells

Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-derived stem cells, the association between BM-MSCs and endometrial stem cells, and progress in repairing endometrial injury.

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Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials

Clinical Oral Investigations ◽

10.1007/s00784-021-03840-9 ◽

2021 ◽

Author(s):

Diana B. Sequeira ◽

Ana Rafaela Oliveira ◽

Catarina M. Seabra ◽

Paulo J. Palma ◽

Carlos Ramos ◽

...

Keyword(s):

Stem Cells ◽

Human Stem Cells ◽

Bioactive Materials ◽

Apical Papilla

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Embryoid research calls for reassessment of legal regulations

Stem Cell Research & Therapy ◽

10.1186/s13287-021-02442-2 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Markus Hengstschläger ◽

Margit Rosner

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Human Embryonic Stem Cells ◽

Legal Status ◽

Embryonic Stem ◽

Basic Research ◽

Human Embryos ◽

Human Being ◽

Legal Regulations ◽

Definition Of

AbstractIt is known that in countries, in which basic research on human embryos is in fact prohibited by law, working with imported human embryonic stem cells (hESCs) can still be permitted. As long as hESCs are not capable of development into a complete human being, it might be the case that they do not fulfill all criteria of the local definition of an embryo. Recent research demonstrates that hESCs can be developed into entities, called embryoids, which increasingly could come closer to actual human embryos in future. By discussing the Austrian situation, we want to highlight that current embryoid research could affect the prevailing opinion on the legal status of work with hESCs and therefore calls for reassessment of the regulations in all countries with comparable definitions of the embryo.

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Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

Molecular Biology of the Cell ◽

10.1091/mbc.e19-08-0447 ◽

2020 ◽

Vol 31 (23) ◽

pp. 2583-2596

Author(s):

John M. Boyle ◽

Kelsey M. Hennick ◽

Samuel G. Regalado ◽

Jacob M. Vogan ◽

Xiaozhu Zhang ◽

...

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Telomere Length ◽

Pluripotent Stem Cells ◽

Human Stem Cells ◽

Set Point ◽

Hypomorphic Allele ◽

Point Control ◽

Set Point Control ◽

Stem Cell Lines

To better understand telomere length set point control in human stem cells, we generated knockout stem cell lines for TPP1 and contrasted their phenotypes with those of homozygous TPP1 L104A mutant stem cells. This comparison reveals that TPP1 L104A is not a hypomorphic allele but formally establishes TPP1 L104 as a dissociation of function mutant.

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