scholarly journals In July 2019 the Portuguese Society of Myology was officially born: the first message from the founders

2019 ◽  
Vol 29 (4) ◽  
Author(s):  
Paula Tavares ◽  
Carlos Fontes Ribeiro
Keyword(s):  
Skeletal Muscle ◽  
International Collaboration ◽  
Muscle Physiology ◽  
System Call ◽  
Muscle System ◽  
Adaptation Capacity ◽  
Public Events ◽  
Portuguese Society ◽  
Scientific Meetings ◽  
The City

The amazing behaviour and adaptation capacity of the skeletal muscle system call the attention of several scientists, including us. Thus, we have the pleasure to announce that it was born in the city of Coimbra, Portugal, the Portuguese Society of Myology (SPMyo), a society which the main aim is to spread skeletal muscle knowledge in the areas of muscle physiology, physiopathology and pharmacology in a multidisciplinary organization that reflects the different areas of the skeletal muscle study. The commitment of SPMyo is the progress of skeletal muscle awareness as well as its investigation, encouraging interdisciplinary, national and international collaboration. These goals will be achieved by organization of scientific meetings, formation courses, publications of books and other scientific and didactic materials. It is also a goal of the SPMyo to organize public events allowing general public to understand skeletal muscle system.

scholarly journals Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease

Cell Calcium ◽  
2018 ◽  
Vol 76 ◽  
pp. 101-115 ◽  
Author(s):  
Antonio Michelucci ◽  
Maricela García-Castañeda ◽  
Simona Boncompagni ◽  
Robert T. Dirksen
Keyword(s):  
Skeletal Muscle ◽  
Muscle Physiology

scholarly journals Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion

2019 ◽  
Vol 3 ◽  
pp. 147 ◽  
Author(s):  
Lucy A. Oakey ◽  
Rachel S. Fletcher ◽  
Yasir S. Elhassan ◽  
David M. Cartwright ◽  
Craig L. Doig ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Carbon Metabolism ◽  
Energy Production ◽  
Quantum Coherence ◽  
Metabolic Energy ◽  
Whole Body ◽  
Muscle Physiology ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Central Carbon ◽  
Metabolic Tracing

Background: Skeletal muscle is central to whole body metabolic homeostasis, with age and disease impairing its ability to function appropriately to maintain health. Inadequate NAD+ availability is proposed to contribute to pathophysiology by impairing metabolic energy pathway use. Despite the importance of NAD+ as a vital redox cofactor in energy production pathways being well-established, the wider impact of disrupted NAD+ homeostasis on these pathways is unknown. Methods: We utilised skeletal muscle myotube models to induce NAD+ depletion, repletion and excess and conducted metabolic tracing to provide comprehensive and detailed analysis of the consequences of altered NAD+ metabolism on central carbon metabolic pathways. We used stable isotope tracers, [1,2-13C] D-glucose and [U-13C] glutamine, and conducted combined 2D-1H,13C-heteronuclear single quantum coherence (HSQC) NMR spectroscopy and GC-MS analysis. Results: NAD+ excess driven by nicotinamide riboside (NR) supplementation within skeletal muscle cells resulted in enhanced nicotinamide clearance, but had no effect on energy homeostasis or central carbon metabolism. Nicotinamide phosphoribosyltransferase (NAMPT) inhibition induced NAD+ depletion and resulted in equilibration of metabolites upstream of glyceraldehyde phosphate dehydrogenase (GAPDH). Aspartate production through glycolysis and TCA cycle activity was increased in response to low NAD+, which was rapidly reversed with repletion of the NAD+ pool using NR. NAD+ depletion reversibly inhibits cytosolic GAPDH activity, but retains mitochondrial oxidative metabolism, suggesting differential effects of this treatment on sub-cellular pyridine pools. When supplemented, NR efficiently reversed these metabolic consequences. However, the functional relevance of increased aspartate levels after NAD+ depletion remains unclear, and requires further investigation. Conclusions: These data highlight the need to consider carbon metabolism and clearance pathways when investigating NAD+ precursor usage in models of skeletal muscle physiology.

scholarly journals Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology

2010 ◽  
Vol 189 (1) ◽  
pp. 95-109 ◽  
Author(s):  
David S. Gokhin ◽  
Raymond A. Lewis ◽  
Caroline R. McKeown ◽  
Roberta B. Nowak ◽  
Nancy E. Kim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thin Filament ◽  
Striated Muscle ◽  
Fiber Type ◽  
Actin Dynamics ◽  
Muscle Physiology ◽  
Skeletal Muscle Function ◽  
Capping Proteins ◽  
Locomotor Deficits ◽  
End Capping

During myofibril assembly, thin filament lengths are precisely specified to optimize skeletal muscle function. Tropomodulins (Tmods) are capping proteins that specify thin filament lengths by controlling actin dynamics at pointed ends. In this study, we use a genetic targeting approach to explore the effects of deleting Tmod1 from skeletal muscle. Myofibril assembly, skeletal muscle structure, and thin filament lengths are normal in the absence of Tmod1. Tmod4 localizes to thin filament pointed ends in Tmod1-null embryonic muscle, whereas both Tmod3 and -4 localize to pointed ends in Tmod1-null adult muscle. Substitution by Tmod3 and -4 occurs despite their weaker interactions with striated muscle tropomyosins. However, the absence of Tmod1 results in depressed isometric stress production during muscle contraction, systemic locomotor deficits, and a shift to a faster fiber type distribution. Thus, Tmod3 and -4 compensate for the absence of Tmod1 structurally but not functionally. We conclude that Tmod1 is a novel regulator of skeletal muscle physiology.

Skeletal Muscle: Physiology, Training and Repair After Injury

2008 ◽  
pp. 49-69 ◽  
Author(s):  
Michael Kjr ◽  
Hannu Kalimo ◽  
Bengt Saltin
Keyword(s):  
Skeletal Muscle ◽  
Muscle Physiology

The Mothers of Tiananmen: Curating Social Justice

2021 ◽  
Vol 10 (2) ◽  
pp. 230-246 ◽  
Author(s):  
Jenna C. Ashton
Keyword(s):  
Social Justice ◽  
Social Action ◽  
Women Artists ◽  
International Collaboration ◽  
Tiananmen Square ◽  
Chinese Populations ◽  
Creative Resistance ◽  
Participatory Arts ◽  
The City

Focusing on the activist exhibition The Mothers of Tiananmen (2019), this article examines my methodology of curating for social action and justice using international collaboration and participatory arts-as-research. The exhibition responded to the ongoing campaign for justice for the victims and survivors of the Tiananmen Square Massacre, as well as sought to support women’s creative resistance and voice. The Mothers of Tiananmen was co-created with artist Mei Yuk Wong, the 64 Museum (Hong Kong), and artists participating in the Centre for International Women Artists (Manchester). The context for the exhibition is the city of Manchester, which has one of the highest Chinese populations in England, along with a diverse international demographic with over 200 languages spoken. Through this case study, curating is presented as a creative and critical tool by which to respond to the range of justice and activist concerns of international and diasporic communities.

The Black Panther Has Died

2016 ◽  
pp. 158-171
Author(s):  
Samuel Mateus
Keyword(s):  
National Identity ◽  
Social Integration ◽  
World Wide ◽  
Media Ecology ◽  
Shared Experience ◽  
Public Events ◽  
Media Events ◽  
The Media ◽  
Portuguese Society ◽  
Media Event

Media ecology is characterized today by the frequent airing of disruptive events. The shared experience of broadcasting is thus taken by disenchantment, fragmentation and individualization. Does this mean that integrative and ceremonial media events are condemned to disappear? What about media rituals and collective consensus? In this chapter, we argue that the Media Events category is not just an invaluable frame to understand contemporary television but it is also a vital process on the way societies re-work their solidarities, negotiate collective belonging and publicly stage social rituals. Analysing the live coverage of the funerary ceremonies of Eusébio, the Portuguese world-wide football legend, we address this major social occurrence approaching it as a death media event, a public mourning ceremonial and a tele-ritual. Media events are still a powerful example of how media plays a major role on social integration and national identity. The television broadcast of Eusébio's funeral - it is claimed - constitutes a key example, in the Portuguese society, of the integrative dimension of public events.

In vivo supraspinatus muscle contractility and architecture in rabbit

2020 ◽  
Vol 129 (6) ◽  
pp. 1405-1412
Author(s):  
Sydnee A. Hyman ◽  
Mackenzie B. Norman ◽  
Shanelle N. Dorn ◽  
Shannon N. Bremner ◽  
Mary C. Esparza ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Isometric Force ◽  
Muscle Physiology ◽  
Mammalian Skeletal Muscle ◽  
Improved Method ◽  
Muscle Contractility ◽  
Supraspinatus Muscle ◽  
Contractile Stress ◽  
Maximum Isometric Force

We introduce an improved method to assess rabbit supraspinatus muscle physiology. Maximum isometric force measured for the rabbit supraspinatus was dramatically greater than previous reports in the literature. Consequently, the isometric contractile stress reported is almost 10 times greater than previous reports of rabbit supraspinatus, but similar to available literature of other mammalian skeletal muscle. We show that previous reports of peak supraspinatus isometric force were subphysiological by ∼90%

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