scholarly journals Absence of chronic hepatitis E in a German cohort of common variable immunodeficiency patients

2012 ◽  
Vol 4 (1) ◽  
pp. 28 ◽  
Author(s):  
Sven Pischke ◽  
Ruediger Horn-Wichmann ◽  
Diana Ernst ◽  
Bjoern Georg Meyer ◽  
Regina Raupach ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Before And After ◽  
Protective Antibodies ◽  
Solid Organ Transplant Recipients ◽  
Common Variable

Cases of chronic or prolonged hepatitis E virus (HEV) infections have been described in solid organ transplant recipients, HIV infected patients and in patients with malignancies or idiopathic CD4+ T lymphopenia. It is unknown if HEV infection also takes chronic courses in patients with common variable immunodeficiency (CVID). We studied a cohort of 73 CVID patients recruited in a low endemic Central European country. None of the subjects tested positive for HEV RNA or anti-HEV IgG. Immunoglobulin transfusions (n=10) tested negative for HEV RNA but all were anti-HEV positive. To verify that such pooled blood products contain anti-HEV protective antibodies we measured the anti-HEV IgG optical density (OD) values in patients before and after transfusion. Anti-HEV OD values increased after infusion but did not reach the cut-off considered as positive. Thus, chronic HEV infections seem to be rare events in CVID patients in Germany. Commercially available immuno globulin infusions contain anti HEV antibodies and may contribute to protection from HEV infection

scholarly journals Hepatitis E Virus Infection among Solid Organ Transplant Recipients, the Netherlands

2012 ◽  
Vol 18 (5) ◽  
pp. 869-872 ◽  
Author(s):  
Suzan D. Pas ◽  
Rob A. de Man ◽  
Claudia Mulders ◽  
Aggie H.M.M. Balk ◽  
Peter T.W. van Hal ◽  
...  
Keyword(s):  
Virus Infection ◽  
The Netherlands ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients

2018 ◽  
Vol 38 (12) ◽  
pp. 2178-2189 ◽  
Author(s):  
Olivier Marion ◽  
Florence Abravanel ◽  
Arnaud Del Bello ◽  
Laure Esposito ◽  
Sebastien Lhomme ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

scholarly journals Hepatitis E Virus Infection Among Solid Organ Transplant Recipients at a North American Transplant Center

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Paul K. Sue ◽  
Nora Pisanic ◽  
Christopher D. Heaney ◽  
Michael Forman ◽  
Alexandra Valsamakis ◽  
...  
Keyword(s):  
Risk Factors ◽  
North America ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Factors Associated ◽  
Solid Organ Transplant Recipients

Abstract Background.  Autochthonous hepatitis E virus (HEV) infection has been reported in over 200 solid organ transplant (SOT) recipients since 2006, yet little is known about the burden of HEV among SOT recipients in North America. We performed a retrospective, cross-sectional study to investigate the prevalence and risk factors associated with HEV infection among SOT recipients at our institution. Methods.  Children and adults (n = 311) who received allografts between 1988 and 2012 at the Johns Hopkins Hospital were assessed for evidence of HEV infection by testing posttransplantation serum samples for HEV antibody by enzyme immunoassay and HEV RNA by reverse transcription quantitative polymerase chain reaction. Individuals with evidence of posttransplant HEV infection (presence of anti-HEV immunoglobulin [Ig]M antibody, anti-HEV IgG seroconversion, or HEV RNA) were compared with individuals without evidence of infection and assessed for risk factors associated with infection. Results.  Twelve individuals (4%) developed posttransplant HEV infection. Posttransplant HEV infection was associated with an increased risk for graft rejection (odds ratio, 14.2; P = .03). No individuals developed chronic infection. Conclusions.  Solid organ transplant recipients in the United States are at risk for posttransplant HEV infection. Further studies are needed to characterize environmental risk factors and the risk of HEV infection after SOT in North America.

scholarly journals Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France

2011 ◽  
Vol 17 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Florence Legrand-Abravanel ◽  
Nassim Kamar ◽  
Karine Sandres-Saune ◽  
Sebastien Lhomme ◽  
Jean-Michel Mansuy ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Characteristics of Autochthonous Hepatitis E Virus Infection in Solid‐Organ Transplant Recipients in France

2010 ◽  
Vol 202 (6) ◽  
pp. 835-844 ◽  
Author(s):  
Florence Legrand‐Abravanel ◽  
Nassim Kamar ◽  
Karine Sandres‐Saune ◽  
Cyril Garrouste ◽  
Martine Dubois ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

scholarly journals Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France

2017 ◽  
Vol 23 (2) ◽  
pp. 353-356 ◽  
Author(s):  
Sebastien Lhomme ◽  
Laurent Bardiaux ◽  
Florence Abravanel ◽  
Pierre Gallian ◽  
Nassim Kamar ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Hepatitis E virus infection in patients on dialysis and in solid organ transplant recipients in Argentina: exploring associated risk factors

2016 ◽  
Vol 162 (3) ◽  
pp. 787-792 ◽  
Author(s):  
María Belén Pisano ◽  
Domingo Balderramo ◽  
Maribel Martínez Wassaf ◽  
Martín Lotto ◽  
Yanina Carlino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Organ Transplant ◽  
Hepatitis E ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Solid Organ Transplant Recipients ◽  
Associated Risk Factors
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