scholarly journals Management of stable coronary artery disease: from evidence to clinical practice

2017 ◽  
Vol 11 (2) ◽  
pp. 114 ◽  
Author(s):  
Riccardo Gerloni ◽  
Luciano Mucci ◽  
Tiziana Ciarambino ◽  
Manuel Ventura ◽  
Valeria Baglio ◽  
...  
Keyword(s):  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Stable Coronary Artery Disease ◽  
Coronary Intervention ◽  
Ischemic Heart ◽  
Cardiac Syndrome ◽  
Percutaneous Coronary ◽  
Artery Disease

Ischemic heart disease, the leading cause of death, is extremely diffuse among patients hospitalized in Internal Medicine ward so that Internist should be able to manage correctly this disease. The following review revises the most recent literature and offers a practical clinical guide to be confident on this topic. After having emphasized that clinical overview remains essential, it briefly mentions advantages and limits of different investigations, reminds readers of possible alternative etiopathogeneses of ischemic heart disease (cardiac syndrome X), reports the most appropriate medical therapy, and gives the opportunity to understand appropriateness of specialist strategies such as coronary artery by-pass grafting and percutaneous coronary intervention. Finally, it illustrates a rational and evidence-based follow-up of these patients, considering that only a small part of them should be followed by a Cardiologist. The aim of a correct management of ischemic heart disease remains to reduce mortality and improve the quality of life.

scholarly journals Risk Assessment of Cardiac Events in Patients with Stable Ischemic Heart Disease After Percutaneous Coronary Intervention, Accompanied by Myocardial Damage

2019 ◽  
Vol 6 (3) ◽  
pp. 15-24
Author(s):  
A. V. Vorobyova ◽  
B. B. Bondarenko ◽  
V. A. Bart ◽  
M. P. Malgina ◽  
V. V. Dorofeykov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Stable Coronary Artery Disease ◽  
Myocardial Damage ◽  
Coronary Intervention ◽  
Ischemic Heart ◽  
Cardiac Events ◽  
Percutaneous Coronary ◽  
Artery Disease

Background. Percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) is followed often by myocardial injury. Up to now there is no mutual agreement to the infl uence of the perioperative myocardial injury on the long-term prognosis of the IHD patients.Objective. The aim of study was to assess the risk factors for the development of cardiac events in the long-term period in patients with stable coronary artery disease with myocardial damage after PCI.Materials and methods. The study included 113 patients with stable coronary artery disease who underwent planned PCI. Serum troponin levels were determined before and 24 hours after the intervention. Re-examination of patients was carried out after 12–18 months (average 15 months).Results. The post PCI Tn I level over a reference one was registered in 25 patients (22,2 %). During the follow-up period the cardiovascular events took place in 25,6 % patients: acute myocardial infarction (MI) in 3 (2,6 %), angina occurred in 23 %. One-way ANOVA revealed a signifi cant value for cardiac risk events of the patient age, number of stenosed arteries, summary degree of stenosis, and their complicity, number of implanted stents. The fi rst three of them were included in the fi nal combination of the stepwise discriminant analysis. The general linear model of the latter detected additionally statistical signifi cance of the variables “MI in the past” (before PCI) and “number of postdilatations“.Conclusion. In patients with stable ischemic heart disease, included in the study, the determining risk factors for the development of cardiac events were the prevalence and nature of the obstructive lesion of the coronary bed, age, previous myocardial infarction, and especially the performance of PCI. Myocardial damage was not identifi ed as a risk factor for recurrent angina or myocardial infarction.

scholarly journals Adipokine status in patients with stable ischemic heart disease associated with affective disorders

2018 ◽  
Vol 9 (3) ◽  
pp. 54-59
Author(s):  
N. P. Dorofeeva ◽  
A. O. Ter-Akopyan ◽  
Yu. N. Оrekhova ◽  
D. N. Ivanchenko ◽  
S. V. Shlyk ◽  
...  
Keyword(s):  
Heart Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Blood Plasma ◽  
Affective Disorders ◽  
Stable Coronary Artery Disease ◽  
Ischemic Heart ◽  
Stable Ischemic Heart Disease ◽  
Artery Disease

One of the factors negatively affecting the cardiac prognosis of coronary heart disease (CHD) is affective disorders of the depressive spectrum. Symptoms of depression may increase the level of systemic inflammation and promote disorders of carbohydrate metabolism by altering the synthesis and secretion of adipokines: leptin, resistin, adiponectin. The aim of this study was to assess the adipokin status in patients with stable coronary artery disease in the conditions of conservative therapy and during percutaneous coronary interventions (PCI) with stenting, including patients with depressive symptoms. The presence of depressive symptoms was accompanied by an increase in the level of resistin in the blood plasma in patients with stable ischemic heart disease. PCI with coronary artery stenting resulted in an increase in the concentration of all the adipokines: adiponectin, leptin, resistin. Stenting of coronary arteries in people with depressive symptoms led to an increase in the level of resistin, adiponectin with a decrease in the concentration of leptin in the blood plasma on the third day after the operative intervention.

Influence long-term use of statins on the course of inflammatory periodontal diseases in coronary artery disease patients

2019 ◽  
Vol 24 (1) ◽  
pp. 89-90
Author(s):  
T. G. Petrova ◽  
N. B. Borodina ◽  
D. A. Yakhontov ◽  
V. V. Vanjunina ◽  
L. D. Peresvet
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Periodontal Diseases ◽  
Ischemic Heart ◽  
Periodontal Inflammation ◽  
Artery Disease

The relevance of the study is due to the high prevalence of inflammatory periodontal diseases in patients with cardiovascular pathology. Currently, for the treatment of ischemic heart disease (IHD), statins are used, which, in addition to hypolipidemic action, have anti-inflammatory properties, which can lead to an increase in the pressure of the inflammatory process, not only in heart vessels, but also in paradonte.The aim of the study was to study the effect of prolonged use of statins on the course of inflammatory periodontal diseases in patients with IHD.Materials and methods. A dental examination and study of the quality of life of 122 patients with ischemic heart disease (IHD) were performed. Surveyed were divided into two groups depending on the duration of receiving lipid-corrective therapy.The results of the study. It has been established that in patients with coronary artery disease who take statins for a long time, the periodontal inflammation activity and the severity of its clinical manifestations are lower than in patients not using lipid-correcting therapy, which was accompanied by improvement in certain parameters of quality of life.

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