scholarly journals Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience

2012 ◽  
Vol 4 (1) ◽  
pp. 6 ◽  
Author(s):  
Antigoni Mavroudi ◽  
Ioannis Xinias ◽  
Aristidis Deligiannidis ◽  
Efthimia Parapanissiou ◽  
George Imvrios
Keyword(s):  
Liver Transplantation ◽  
Food Allergy ◽  
Food Allergies ◽  
Food Allergens ◽  
Long Term Outcome ◽  
The Third ◽  
Pediatric Liver ◽  
Number Of Patients ◽  
Long Term Prognosis

Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far. We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persistent diarrhea and eczema. The second one presented with abdominal pain with no signs of rejection, abdominal discomfort, vomiting when ingesting milk proteins and responded well to the elimination diet. The third patient presented with facial angioedema and hoarseness of voice. She had multiple food allergies and reacted to milk, egg and sesame. All the patients had elevated total Immunoglobulin E (<em>IgE</em>) and elevated specific <em>IgE</em> antibodies to the implicated food allergens. The first patient presented clinical manifestations of allergy when she was 19 months old. The second patient became allergic at the age of 16 and the third patient at the age of 3. The symptoms of food allergy persisted for 8 years in the first case and for 2 years in the other two cases. Low levels of specific <em>IgE</em> antibodies to the implicated food allergens and an enhanced T-helper 1 cell immune response toward interferon-gamma production were markers of tolerance acquisition. The long term prognosis in our cases was excellent. Food allergy resolved in all the patients. The long term prognosis of acquired food allergy after liver transplantation is currently obscure. More studies would be needed including greater number of patients to determine whether acquired food allergy is transient in pediatric liver recipients.

scholarly journals Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience

10.4081/4000 ◽  
2012 ◽  
Vol 4 (1) ◽  
Author(s):  
Antigoni Mavroudi ◽  
Ioannis Xinias ◽  
Aristidis Deligiannidis ◽  
Efthimia Parapanissiou ◽  
George Imvrios
Keyword(s):  
Food Allergy ◽  
Single Center ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Single Center Experience ◽  
Pediatric Liver

Long-term outcome of hepatitis C virus infections acquired after pediatric liver transplantation

2011 ◽  
Vol 17 (12) ◽  
pp. 1474-1480 ◽  
Author(s):  
Carla Venturi ◽  
Javier Bueno ◽  
Lluís Castells ◽  
Jesus Quintero ◽  
Isabel Casas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Pediatric Liver Transplantation ◽  
Virus Infections ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Pediatric Liver

Long-term outcome following pediatric liver transplantation for metabolic disorders

2009 ◽  
Vol 14 (2) ◽  
pp. 268-275 ◽  
Author(s):  
Terrell Stevenson ◽  
Maria T. Millan ◽  
Karen Wayman ◽  
William E. Berquist ◽  
Minnie Sarwal ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Metabolic Disorders ◽  
Pediatric Liver Transplantation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Pediatric Liver

Long-term outcome of pediatric liver transplantation for biliary atresia: A 10-year follow-up in a single center

2005 ◽  
Vol 11 (2) ◽  
pp. 152-160 ◽  
Author(s):  
Virginie Fouquet ◽  
Arnaud Alves ◽  
Sophie Branchereau ◽  
Sophie Grabar ◽  
Dominique Debray ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Biliary Atresia ◽  
Pediatric Liver Transplantation ◽  
Single Center ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Pediatric Liver

scholarly journals Characteristics and Long-term Outcome of 535 Patients with Histologically Confirmed Autoimmune Hepatitis (AIH) - A Single Center Experience of 18 Years

2021 ◽  
Author(s):  
Matthias Buechter ◽  
Johannes Kessener ◽  
Birte Möhlendick ◽  
Hideo A. Baba ◽  
Guido Gerken ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Autoimmune Hepatitis ◽  
Smooth Muscle Actin ◽  
Primary Biliary Cholangitis ◽  
Type I ◽  
Long Term Outcome ◽  
Number Of Patients ◽  
Almost All ◽  
Long Term Experience

Abstract Introduction: Autoimmune hepatitis (AIH) is a rare liver disease with a favorable prognosis following immunosuppression. In this work-up, we present our long-term experience with this patient collective. Patients and Methods: Overall, we were able to retrospectively evaluate data from 535 patients with histologically confirmed AIH over a period of 18 years between 2002 and 2020. Results: As expected, almost ¾ of the patients were women (74.5 %) of middle age (47.0 ± 14.9 years). Type I AIH was diagnosed in almost all patients (97.5 %). However, 88 patients (16.4 %) revealed an overlap to primary biliary cholangitis (PBC). In contrast, overlap to primary sclerosing cholangitis (PSC) was detected in only 22 patients (3.7 %). Regarding auto-antibody profile, positivity for anti-nuclear antibodies (ANA) was found in 388 patients (72.5 %); smooth-muscle actin (SMA)-titer was positive in 90 patients (16.8 %), anti-mitochondrial antibodies (AMA) were detected in 43 individuals (8.0 %), and we found positive p-anti-neutrophil cytoplasmic antibodies (p-ANCA) in 12 patients (2.2 %). More than ¾ of the patients (n = 417 ≈ 77.9 %) were initially treated with corticosteroids (1 mg/kg/day) and this therapy was continued in almost all subjects (97.4 %) in low dose (5 - 7.5 mg/day) as maintenance therapy. Steroid-saving and remission-maintaining therapy with azathioprine was carried out in 380 patients (71.0 %). Mycophenolate mofetil (MMF) or calcineurin-inhibitors (CNI) were used as second- or third-line immunosuppression. Acute liver failure (ALF) - as the first manifestation of AIH - was diagnosed in 101 patients (18.8 %). Hepatocellular carcinoma (HCC) was detected in at least 6 patients (1.1 %). Liver transplantation (LT) was performed in 51 patients (9.5 %) who progressed to cirrhosis despite immunosuppression. Unfortunately, a total of 45 patients (8.4 %) died of cirrhosis-related complications (infected ascites, bleeding, encephalopathy) without chance for adequate organ offer.Conclusion: We here present our long-term experience with a significant number of patients diagnosed with AIH over a long observation period of 18 years. In general, patients with AIH can adequately be managed with good clinical outcome at a liver center requiring immunosuppressive therapy. However, HCC-screening, acute-on-chronic (AOC) liver decompensation, or liver transplantation have to be taken into consideration carefully.

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