Novel therapeutic approaches to squamous cell carcinoma of the head and neck using biologically targeted agents

2010 ◽  
Vol 47 (3) ◽  
pp. 248 ◽  
Author(s):  
KJ Harrington ◽  
R Kazi ◽  
SA Bhide ◽  
K Newbold ◽  
CM Nutting
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Targeted Agents ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

scholarly journals Methyltransferases in the Pathogenesis of Keratinocyte Cancers

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3402
Author(s):  
Eun Kyung Ko ◽  
Brian C. Capell
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Histone Methylation ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Therapeutic Approaches ◽  
Novel Therapeutic

Recent evidence suggests that the disruption of gene expression by alterations in DNA, RNA, and histone methylation may be critical contributors to the pathogenesis of keratinocyte cancers (KCs), made up of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), which collectively outnumber all other human cancers combined. While it is clear that methylation modifiers are frequently dysregulated in KCs, the underlying molecular and mechanistic changes are only beginning to be understood. Intriguingly, it has recently emerged that there is extensive cross-talk amongst these distinct methylation processes. Here, we summarize and synthesize the latest findings in this space and highlight how these discoveries may uncover novel therapeutic approaches for these ubiquitous cancers.

Breakthrough targeted therapeutic approaches to squamous cell carcinoma of the head and neck

2015 ◽  
Vol 11 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Alberto Mangano ◽  
Alessandro Mangano ◽  
Georgios D Lianos ◽  
Dimitrios H Roukos ◽  
Alberto Caprioglio ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Approaches ◽  
Targeted Therapeutic

MET and RON Receptor Tyrosine Kinases: Novel Therapeutic Targets in Squamous Cell Carcinoma of the Head and Neck

2007 ◽  
Vol 3 (1) ◽  
pp. 1-12
Author(s):  
Susanne Rogers ◽  
Carol Box ◽  
Christopher Nutting ◽  
Peter Rhys Evans ◽  
Kevin Harrington ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Therapeutic Targets ◽  
Ron Receptor ◽  
Novel Therapeutic

scholarly journals Immunotherapy in head and neck squamous cell carcinoma and rare head and neck malignancies

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Stefano Cavalieri ◽  
Daria Maria Filippini ◽  
Arianna Ottini ◽  
Cristiana Bergamini ◽  
Carlo Resteghini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Checkpoint Inhibitors ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Approaches ◽  
Dismal Prognosis ◽  
Genomic Landscape

The dismal prognosis of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) prompted recent advances in the field of therapeutic approaches beyond cytotoxic cancer therapy. In recent years, the deeper and increasing knowledge on the genomic landscape and the upcoming new data on immunotherapy enacted by HNSCCs have led to successful therapeutic targeting of the immune system. Immune checkpoint inhibitors (ICIs) have changed state of the art in R/M patients and could have a potential role even in early disease. The purpose of this work is to summarize the role of immunotherapy for R/M HNSCC in clinical practice, with insights about future perspectives. Updated immunotherapy results in other R/M head and neck cancers such as thyroid, salivary glands, nasopharynx, sinonasal cancers, and nuclear protein in testis (NUT) are presented.

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