Enhanced resection of primary high-grade gliomas using a combination of intraoperative magnetic resonance imaging and intraoperative fluorescence (5-aminolevulinic acid): A single-centre experience

2018 ◽  
Vol 66 (3) ◽  
pp. 747 ◽  
Author(s):  
AjayaN Jha ◽  
Vikas Sharma ◽  
Rishabh Kedia ◽  
KaranjitS Narang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Aminolevulinic Acid ◽  
High Grade ◽  
Resonance Imaging ◽  
Single Centre ◽  
Intraoperative Magnetic Resonance Imaging ◽  
Single Centre Experience ◽  
High Grade Gliomas ◽  
Intraoperative Fluorescence

scholarly journals Improving contrast enhancement in magnetic resonance imaging using 5-aminolevulinic acid-induced protoporphyrin IX for high-grade gliomas

2016 ◽  
Vol 13 (3) ◽  
pp. 1269-1275 ◽  
Author(s):  
Junkoh Yamamoto ◽  
Shingo Kakeda ◽  
Tetsuya Yoneda ◽  
Shun-Ichiro Ogura ◽  
Shohei Shimajiri ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
High Grade ◽  
Resonance Imaging ◽  
High Grade Gliomas

Results of Irradiation in Patients with High-Grade Gliomas Evaluated by Magnetic Resonance Imaging

1995 ◽  
Vol 18 (4) ◽  
pp. 297-299 ◽  
Author(s):  
R. B. Seither ◽  
B. Jose ◽  
K. J. Paris ◽  
R. D. Lindberg ◽  
W. J. Spanos
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Grade ◽  
Resonance Imaging ◽  
High Grade Gliomas

Use of Magnetic Resonance Imaging to Assess Blood-Brain/Blood-Glioma Barrier Opening During Conformal Radiotherapy

2005 ◽  
Vol 23 (18) ◽  
pp. 4127-4136 ◽  
Author(s):  
Yue Cao ◽  
Christina I. Tsien ◽  
Zhou Shen ◽  
Daniel S. Tatro ◽  
Randall Ten Haken ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Conformal Radiotherapy ◽  
High Grade ◽  
Resonance Imaging ◽  
Blood Brain ◽  
Contrast Enhanced ◽  
Tumor Region ◽  
Region Contrast ◽  
High Grade Gliomas

Purpose For chemotherapy to act synergistically and safely with radiation against high-grade gliomas, drugs must pass the endothelial junctions of the blood-tumor barrier (BTB) to reach all tumor cells, and should not pass the blood-brain barrier (BBB) to cause toxicity to normal brain. The objective of this study was to assess BBB/BTB status using magnetic resonance imaging (MRI) during a course of radiotherapy of high-grade gliomas. Patients and Methods Sixteen patients with grade 3 or 4 supratentorial malignant glioma receiving conformal radiotherapy (RT) underwent contrast-enhanced MRI before, during, and after completion of RT. A gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) uptake index was analyzed with respect to the tumor and RT dose received. Results In the nonenhanced tumor region, contrast uptake increased significantly after the receipt of approximately 10 Gy (P < .01), and reached a maximum after the receipt of approximately 30 Gy. In the initially contrast-enhanced tumor region, contrast uptake decreased over the course of RT and became significant after completion of RT in patients without progressive disease. The healthy brain showed only nonsignificant changes during and after irradiation. Conclusion Contrast MRI reveals increases in Gd-DTPA uptake in the initially nonenhanced tumor region but not in the remaining brain during the course of RT, suggesting opening of the BTB. This finding suggests that the effect of conformal radiation is more selective on the BTB than the BBB, and there may be a window extending from 1 week after the initiation of radiotherapy to 1 month after the completion of treatment during which a pharmaceutical agent has maximum access to high-grade gliomas.

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