scholarly journals Enhanced dissolution and stability of Tanshinone IIA base by solid dispersion system with nano-hydroxyapatite

2014 ◽  
Vol 10 (39) ◽  
pp. 332 ◽  
Author(s):  
Yan-rong Jiang ◽  
Zhen-hai Zhang ◽  
Sai-yan Huang ◽  
Yan Lu ◽  
Tian-tian Ma ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Tanshinone Iia ◽  
Dispersion System ◽  
Enhanced Dissolution

ENHANCED DISSOLUTION OF A POORLY WATER-SOLUBLE DRUG BY SOLID DISPERSIONS (SOLVENT EVAPORATION) TECHNIQUE

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (06) ◽  
pp. 13-19
Author(s):  
R. O Sonawane ◽  
◽  
S. Nayak ◽  
M. D. Chaudhari ◽  
V. V. Pande
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Water Soluble ◽  
Differential Scanning Calorimetric ◽  
Maximum Enhancement ◽  
Enhanced Dissolution ◽  
Water Soluble Drugs ◽  
Fusion Methods ◽  
Poorly Water Soluble

The poorly water soluble drugs tend to have low bioavailability and this can be improved by several methods. Solid dispersion is a promising formulation approach to improve solubility and dissolution and ultimately oral bioavailability of these drugs. The aim of this study was to prepare and characterize solid dispersion of anti-diabetic glimepiride, a BCS class II drug, with the hydrophilic carrier PVP K30 by solvent evaporation and microwave induced fusion methods. Scanning electron microscopy (SEM), X–ray powder diffractometry (XRD) and differential scanning calorimetric (DSC) were used to evaluate the physical state of the drug. The solid dispersions were also evaluated for drug content, solubility and dissolution studies. Solid dispersions prepared by solvent evaporation method were showed maximum enhancement of solubility and dissolution in comparison to that prepared by other method.

A novel tanshinone IIA/chitosan solid dispersion: Preparation, characterization and cytotoxicity evaluation

2019 ◽  
Vol 49 ◽  
pp. 260-267 ◽  
Author(s):  
Chao Luo ◽  
Weibin Wu ◽  
Xinyu Lin ◽  
Yaoqi Li ◽  
Kai Yang
Keyword(s):  
Solid Dispersion ◽  
Tanshinone Iia

Study on Enhanced Dissolution of Azilsartan-Loaded Solid Dispersion, Prepared by Combining Wet Milling and Spray-Drying Technologies

2016 ◽  
Vol 18 (2) ◽  
pp. 473-480 ◽  
Author(s):  
Tianshu Lu ◽  
Yinghua Sun ◽  
Dawei Ding ◽  
Qi Zhang ◽  
Rui Fan ◽  
...  
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Wet Milling ◽  
Enhanced Dissolution

Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants

2009 ◽  
Vol 73 (1) ◽  
pp. 154-161 ◽  
Author(s):  
P. Srinarong ◽  
J.H. Faber ◽  
M.R. Visser ◽  
W.L.J. Hinrichs ◽  
H.W. Frijlink
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Enhanced Dissolution

scholarly journals FORMULATION OF ATOVAQUONE TABLET USING BIOSURFACTANT IN A TERNARY SOLID DISPERSION SYSTEM: IN VITRO AND IN VIVO EVALUATION

2019 ◽  
pp. 44-49
Author(s):  
UDAYKUMAR B. BOLMAL ◽  
PRAMOD H. J.
Keyword(s):  
Ternary System ◽  
Solid Dispersion ◽  
Methyl Cellulose ◽  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
In Vivo Evaluation ◽  
Enhanced Dissolution ◽  
Bioavailability Study

Objective: The goal of the present investigation was to improve the solubility and bioavailability of atovaquone tablet, using in-house biosynthesized biosurfactant in the ternary system of solid dispersion containing hydrophilic polymers with varying concentrations of biosurfactant. Atovaquone is an anti-malarial agent and belongs to biopharmaceutical classification system class IV. Methods: The solid dispersion of binary and ternary mixture was prepared using hydroxyl propyl methyl cellulose (HPMC) and biosurfactant respectively by a solvent evaporation method. All the atovaquone tablet formulations were prepared by incorporation of physical mixture, binary and ternary solid dispersed products with excipients by direct compression method. Pre-compression and post-compression parameters of atovaquone tablets were evaluated. In vivo bioavailability study was performed using female albino rabbits. Results: In vitro dissolution profile of binary and ternary system of solid dispersion products showed 8.65% and 34.64% respectively. Precompression and post-compression values of all atovaquone tablets formulations were within the specified limits. In vitro dissolution efficiency of F2 and F5 were 1.44 fold and 6.62 fold respectively, in accordance to the F1. In vivo study revealed that bioavailability of optimized formulation F5 was increased by 2.5 times and time to reach peak concentration was reduced to 1.4 h, in accordance to pure atovaquone suspension. Conclusion: Potential application of biosurfactant in the solid dosage form of atovaquone tablet was proved for enhanced dissolution rate and bioavailability of atovaquone for malaria treatment.

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