Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan

2013 ◽  
Vol 65 (6) ◽  
pp. 839-846 ◽  
Author(s):  
Qi-yuan Liu ◽  
Zhen-hai Zhang ◽  
Xin Jin ◽  
Yan-Rong Jiang ◽  
Xiao-Bin Jia
Keyword(s):  
Molecular Weight ◽  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Tanshinone Iia ◽  
Low Molecular Weight ◽  
Dispersion System ◽  
Enhanced Dissolution ◽  
Low Molecular Weight Chitosan

scholarly journals Enhanced dissolution and stability of Tanshinone IIA base by solid dispersion system with nano-hydroxyapatite

2014 ◽  
Vol 10 (39) ◽  
pp. 332 ◽  
Author(s):  
Yan-rong Jiang ◽  
Zhen-hai Zhang ◽  
Sai-yan Huang ◽  
Yan Lu ◽  
Tian-tian Ma ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Tanshinone Iia ◽  
Dispersion System ◽  
Enhanced Dissolution

Preparation of low-molecular-weight chitosan by enzymatic hydro-lysis for use in peliculture

2021 ◽  
pp. 31-33
Author(s):  
Элана Игоревна Ковалева ◽  
Марина Алексеевна Фролова ◽  
Алексей Иванович Албулов ◽  
Валерий Петрович Варламов ◽  
Анатолий Константинович Елисеев
Keyword(s):  
Molecular Weight ◽  
Enzymatic Hydrolysis ◽  
Environmental Factors ◽  
Low Molecular Weight ◽  
Technological Parameters ◽  
Low Molecular Weight Chitosan

Хитозан и его производные обладают множеством свойств, которые позволяют применять его в пчеловодстве. Он повышает устойчивость организма пчел к неблагоприятным факторам внешней среды и к возбудителям различных заболеваний. В результате проведенных исследований разработаны технологические параметры получения низкомолекулярного хитозана методом ферментативного гидролиза. Chitosan and its derivatives have many properties that allow them to be used in beekeeping. It increases the resistance of the bee organism to adverse environmental factors and to pathogens of various diseases. As a result of the conducted research, the technological parameters for the production of low-molecular-weight chitosan by enzymatic hydrolysis were developed.

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

2009 ◽  
Vol 379 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Ning Li ◽  
Chunyang Zhuang ◽  
Mi Wang ◽  
Xiyang Sun ◽  
Shufang Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Ocular Drug Delivery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan ◽  
Potential Use

Low molecular weight chitosan-based conjugates for efficient Rhein oral delivery: synthesis, characterization, and pharmacokinetics

2018 ◽  
Vol 45 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Jingwen Luo ◽  
Jiang Sun ◽  
Xiaoting Luo ◽  
Yinghui Wei ◽  
Hangsheng Zheng ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Oral Delivery ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan

Searching for synergistic effects of low-molecular weight chitosan derivatives, chitosan and copper nanoparticles for wound healing ointment

2021 ◽  
Vol 12 (3) ◽  
pp. 035016
Author(s):  
Natalya Nikolaevna Glushchenko ◽  
Olga Alexandrovna Bogoslovskaya ◽  
Balzhima Tsyrendorzhievna Shagdarova ◽  
Alla Victorovna Il’ina ◽  
Irina Pavlovna Olkhovskaya ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Wound Healing ◽  
Copper Nanoparticles ◽  
Synergistic Effects ◽  
Low Molecular Weight ◽  
Chitosan Derivatives ◽  
Low Molecular Weight Chitosan

The use of enzymatic preparation for the production of low molecular-weight chitosan from the king crab hepatopancrease

2009 ◽  
Vol 45 (4) ◽  
pp. 374-379 ◽  
Author(s):  
A. V. Ilyina ◽  
D. S. Zagorskaya ◽  
A. N. Levov ◽  
A. I. Albulov ◽  
N. P. Kovacheva ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Enzymatic Preparation ◽  
King Crab ◽  
Low Molecular Weight Chitosan

γ-Ray Irradiation Practical Conditions for Low Molecular Weight Chitosan Material Production

2003 ◽  
Vol 792 ◽  
Author(s):  
Rangrong Yoksan ◽  
Mitsuru Akashi ◽  
Mikiji Miyata ◽  
Siriratana Biramontri ◽  
Suwabun Chirachanchai
Keyword(s):  
Molecular Weight ◽  
Acetic Acid ◽  
Solid State ◽  
Primary Structure ◽  
Low Molecular Weight ◽  
Aqueous Acetic Acid ◽  
Low Molecular Weight Chitosan ◽  
Backbone Structure ◽  
Γ Ray ◽  
Terminal Chain

ABSTRACTThe present work focuses on the γ-ray irradiation doses and conditions (dry solid state, solid state dispersing in 0.5–2 % aqueous H2O2 solution, solid state dispersing in 1% aqueous acetic acid, and 2% aqueous K2S2O8) to determine the level that the molecular weight of chitosan is lowered significantly without changing its primary structure. Molecular weight of chitosan (105-106 Dalton) is reduced approximately 50% under the γ-ray dose of 20 kGy in the dry solid state. The decrease in molecular weight is enhanced up to 80% when chitosan is suspended in 0.5–2 % aqueous H2O2 solution during γ-ray irradiation. In either condition, the backbone structure of the irradiated product is maintained with little change in the terminal chain. In the cases of (i) chitosan suspended in 2% aqueous K2S2O8 and (ii) chitosan in 1% aqueous acetic acid, chitosans lose their primary structures and physical properties.

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