Assessment of quality of life in children with nephrotic syndrome at a teaching hospital in South India

Abstract Introduction Most of the studies reporting the negative impact of idiopathic nephrotic syndrome on health-related quality of life in children and adolescents were conducted with generic quality-of-life instruments rather than disease-specific instruments. The consistency of these studies' findings using these generic instruments is not well established. Aim This systematic review aims to determine the reliability of current generic quality-of-life instruments in assessing health-related quality of life among children and adolescents with idiopathic nephrotic syndrome. Methods We searched the PubMed, MEDLINE, EMBASE, and Google Scholar databases for articles published between 2000 and 2020, using appropriate descriptors. We included primary studies that met the eligibility criteria, independently screened their titles and abstracts, and removed all duplicates during the study-selection process. We resolved disagreements until a consensus was reached on study selection. We independently retrieved relevant data, including the generic quality-of-life instruments and the subjects’ and controls’ aggregate health-related quality of life scores, using a preconceived data-extraction form. Results Ten original articles were selected for qualitative and quantitative analyses. Some of the studies reported the following significant findings. The mean health-related quality of life scores for children with prevalent and incident nephrotic syndrome were 68.6 (range, 52.6–84.6) and 73.7 (range, 55.9–91.5), respectively. Children with idiopathic nephrotic syndrome and their controls with other chronic diseases had median scores of 65 (interquartile range, 59–68.75) and 62.2 (interquartile range, 58.05–65.78). Patients on oral immunosuppressive drug and intravenous rituximab reportedly had median scores of 76.2 and 72.6 and mean scores of 71.4 (range, 55.4–87.4) and 61.6 (range, 42.1–81.1) respectively for quality-of-life assessment on the ‘school functioning domain.’ Conclusions The health-related quality of life scores in patients with idiopathic nephrotic syndrome are consistently low. Lower scores occur in prolonged disease duration and severe clinical phenotypes, whereas the scores are higher than the scores obtained in other chronic diseases. These consistent findings underscore the reliability of the current generic instruments in assessing health-related quality of life in patients with idiopathic nephrotic syndrome.

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Prospective Evaluation of Outcomes and Quality of Life between Operative Approaches for Esophagectomy at a Tertiary Cancer Care Centre in South India

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2020.11.281 ◽

2021 ◽

Vol 47 (2) ◽

pp. e52-e53

Author(s):

Faheeem Abdulla ◽

Chandramohan Krishnan Nair ◽

Madhu Muralee ◽

Wagh Mira Sudham ◽

Bharath Veerabhadran

Keyword(s):

Quality Of Life ◽

Cancer Care ◽

South India ◽

Care Centre ◽

Prospective Evaluation

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SAT-316 HEALTH RELATED QUALITY OF LIFE OF CHILDREN WITH NEPHROTIC SYNDROME IN LAGOS NIGERIA

Kidney International Reports ◽

10.1016/j.ekir.2019.05.358 ◽

2019 ◽

Vol 4 (7) ◽

pp. S140 ◽

Cited By ~ 1

Author(s):

A. Solarin ◽

M. Adekunle ◽

H. Gbelee ◽

A. Animashaun ◽

F. Njokanma

Keyword(s):

Quality Of Life ◽

Nephrotic Syndrome ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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CLINICAL CASE: STEROID-RESISTANT NEPHROTIC SYNDROME

Farmaciâ Kazahstana ◽

10.53511/pharmkaz.2021.94.96.003 ◽

2021 ◽

pp. 13-17

Author(s):

А.Е. Турсын

Keyword(s):

Quality Of Life ◽

Nephrotic Syndrome ◽

Arterial Hypertension ◽

Clinical Case ◽

Steroid Resistant ◽

Steroid Resistant Nephrotic Syndrome ◽

Moderate Severity ◽

Syndrome Diagnosis ◽

Pathogenetic Therapy

Описан клинический случай пациент с нефротическим синдромом, стероид резистентный вариант, с артериальной гипертензией, осложненный полисерозитом (гидроторакс, асцит, плеврит). Пациент поступил в клинику в состоянии средней степени тяжести, с массивными отеками, полисерозитом, артериальной гипертензией и выраженным нефротическим синдромом. Диагноз: Гломерулярная болезнь. Нефротический синдром, стероид резистентный вариант. Функция почек снижена (СКФ- 84мл/мин по Шварцу). Двухсторонний экссудативный плеврит. Гидроторакс. Полисерозит (в рамках нефротического синдрома) был установлен на основании выраженного нефротического синдрома. Пациенту была проведена патогенетическая терапия. Отмечено улучшение состояния больного, в виде снижения отеков, нормализаций артериального давления, что в свою очередь поспособствовало сохранению и улучшению качества жизни пациента. A clinical case of a patient with nephrotic syndrome, steroidresistant variant, with arterial hypertension complicated by polyserositis (hydrothorax, ascites, pleurisy) is described. The patient was admitted to the clinic in a state of moderate severity, with massive edema, polyserositis, arterial hypertension, and severe nephrotic syndrome. Diagnosis: Glomerular disease. Nephrotic syndrome, steroidresistant variant. The kidney function is reduced (GFR - 84 ml/min according to Schwartz). Bilateral exudative pleurisy. Hydrothorax. Polyserositis (within the framework of nephrotic syndrome) was established based on the severe nephrotic syndrome. The patient underwent pathogenetic therapy. An improvement in the patient's condition was noted, in the form of a decrease in edema, normalization of blood pressure, which in turn contributed to the preservation and improvement of the patient's quality of life.

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