A randomized, single-blind, active controlled study to compare the efficacy of salicylic acid and mandelic acid chemical peel in the treatment of mild to moderately severe acne vulgaris

2017 ◽  
Vol 1 (1) ◽  
pp. 15 ◽  
Author(s):  
ShishiraR Jartarkar ◽  
Bugude Gangadhar ◽  
M Mallikarjun ◽  
P Manjunath
Keyword(s):  
Salicylic Acid ◽  
Mandelic Acid ◽  
Acne Vulgaris ◽  
Controlled Study ◽  
Severe Acne ◽  
Single Blind

scholarly journals Glycolic Acid, Lactic Acid, Mandelic Acid, Salicylic Acid, Citric Acid, Gluconolactone: Skin Exfoliators in Combination Therapy of Acne Vulgaris

2020 ◽  
Vol 3 (10) ◽  
pp. 54-55
Author(s):  
Vishal Saxena ◽  
Krishana Yadav
Keyword(s):  
Salicylic Acid ◽  
Mandelic Acid ◽  
Glycolic Acid ◽  
Research Study ◽  
Acne Vulgaris ◽  
Hydroxy Acids ◽  
Skin Texture ◽  
Severe Acne ◽  
Alpha Hydroxy Acids ◽  
Facial Acne

Facial acne are a recurring issue in most of the population and can cause disturbing skin issues. A combination of Alpha-hydroxy acids, Beta-hydroxy-acids and Poly-hydroxy acids has become popular for treating acne vulgaris in last few years. The main objective of this research study is to evaluate the efficacy & safety of combination of these acids in the treatment of acne vulgaris. The study was conducted on 12 volunteers having mild to moderate to severe acne. They were divided into 3 groups according to the severity of their facial acne. Members of each group were treated with a series of 30% AHA, 2% BHA and 7% PHA. The improvement in their acne condition as well as skin texture was assessed over a period of 6 weeks.

FMX101 4% Topical Minocycline Foam for the Treatment of Moderate-to-Severe Acne Vulgaris: Efficacy and Safety From a Phase 3 Randomized, Double-Blind, Vehicle-Controlled Study

2018 ◽  
Vol 2 ◽  
pp. S56 ◽  
Author(s):  
Joseph Raoof ◽  
Deirdre Hooper ◽  
Angela Moore ◽  
Martin Zaiac ◽  
Tory Sullivan ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Controlled Study ◽  
Efficacy And Safety ◽  
Phase 3 ◽  
Double Blind ◽  
Severe Acne

Abstract not available. Disclosures: Study sponsored by Foamix Pharmaceuticals.Copyright 2018 SKIN

scholarly journals Topical minocycline foam for moderate to severe acne vulgaris: Phase 2 randomized double-blind, vehicle-controlled study results

2016 ◽  
Vol 74 (6) ◽  
pp. 1251-1252 ◽  
Author(s):  
Avner Shemer ◽  
Joseph Shiri ◽  
Jacob Mashiah ◽  
Renata Farhi ◽  
Aditya K. Gupta
Keyword(s):  
Acne Vulgaris ◽  
Controlled Study ◽  
Phase 2 ◽  
Double Blind ◽  
Severe Acne ◽  
Study Results

Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study

2011 ◽  
Vol 165 (2) ◽  
pp. 383-390 ◽  
Author(s):  
B. Dréno ◽  
R. Kaufmann ◽  
S. Talarico ◽  
V. Torres Lozada ◽  
M.A. Rodríguez-Castellanos ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Controlled Study ◽  
Double Blind ◽  
Severe Acne

Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild‐to‐moderate acne vulgaris

2019 ◽  
Vol 19 (2) ◽  
pp. 393-399
Author(s):  
Surabhi Dayal ◽  
Kirti Dudeja Kalra ◽  
Priyadarshini Sahu
Keyword(s):  
Salicylic Acid ◽  
Comparative Study ◽  
Mandelic Acid ◽  
Acne Vulgaris ◽  
Efficacy And Safety ◽  
Acid Versus

scholarly journals A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Kanokvalai Kulthanan ◽  
Suphattra Trakanwittayarak ◽  
Papapit Tuchinda ◽  
Leena Chularojanamontri ◽  
Pichaya Limphoka ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Acne Vulgaris ◽  
Maintenance Phase ◽  
Asian Population ◽  
Vehicle Group ◽  
Controlled Study ◽  
Licochalcone A ◽  
Acne Lesion ◽  
Significant Difference ◽  
The Mean

Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of mild to moderate acne in Thai patients. Methods. One hundred and ten patients with mild to moderate acne vulgaris were initially treated with a fixed combination of adapalene 0.1%/benzoyl peroxide 2.5% gel once daily for 8 weeks. Fifty patients who achieved at least 50% reduction in lesion counts or at least a 2-grade improvement in the Investigator’s Global Assessment (IGA) grade from baseline were enrolled in the maintenance phase, which was an investigator-masked, left-right comparison, randomized, controlled, intraindividual study. Moisturizers with and without the active study ingredients were applied twice a day to each side of the face, respectively, for 12 weeks. Assessments included acne lesion counts, acne severity by IGA scoring, skin bioengineering measurements, and skin tolerability as assessed by both patient and physician. Results. The treatment group had a significant reduction in the mean counts of noninflammatory, inflammatory, and total lesions compared to the vehicle group at week 12 and also between baseline and week 12. There was no significant difference in the mean scores for skin dryness, stinging/burning, or pruritus at any time point between groups. Conclusions. Moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid reduced acne lesions and prevented the development of new lesions during the maintenance phase. This trial is registered with ClinicalTrials.gov registration no. NCT04002024.

The Efficacy and Safely of a Combination Benzoyl Peroxide/Clindamycin Topical Gel Compared with Benzoyl Peroxide Alone and a Benzoyl Peroxide/Erythromycin Combination Product

2001 ◽  
Vol 5 (1) ◽  
pp. 37-42 ◽  
Author(s):  
James J. den Ley ◽  
Janet G. Hickman ◽  
Michael T. Jarratt ◽  
Daniel M. Stewart ◽  
Sharon F. Levy
Keyword(s):  
Benzoyl Peroxide ◽  
Acne Vulgaris ◽  
Combination Product ◽  
Efficacy And Safety ◽  
Nonsignificant Trend ◽  
Dry Skin ◽  
Individual Agent ◽  
Severe Acne ◽  
Topical Gel ◽  
Single Blind

Background: Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in tandem, they promise greater efficacy than either individual agent through their antibacterial and anti-inflammatory effects. Objective: To determine the efficacy and safety of combination benzoyl peroxide/clindamycin compared with benzoyl peroxide or benzoyl peroxide/erythromycin in the treatment of acne. Methods: In this randomized, 10-week, multicenter, single-blind trial, 492 patients with moderate to moderately severe acne were treated twice daily with 5% benzoyl peroxide/1% clindamycin, 5% benzoyl peroxide, or 5% benzoyl peroxide/3% erythromycin and assessed every 2 weeks. Results: Compared with benzoyl peroxide, benzoyl peroxide/clindamycin demonstrated significantly greater reductions in inflammatory lesions ( p = 0.04) and significantly greater overall improvement as assessed by physicians (p ⩽ 0.04) and patients ( p ≤ 0.001). Benzoyl peroxide/clindamycin demonstrated a nonsignificant trend for greater efficacy compared to benzoyl peroxide/erythromycin. Dry skin was the most frequent (⩽7.3%) adverse event with all three therapies. Conclusion: Benzoyl peroxide/clindamycin demonstrated improved efficacy and similar tolerability to benzoyl peroxide used alone and was similar to benzoyl peroxide/erythromycin, making this combination product an effective alternative antimicrobial therapy for acne.

scholarly journals Combination Therapy With Adapalene Gel 0.1% and Doxycycline for Severe Acne Vulgaris: A Multicenter, Investigator‐Blind, Randomized, Controlled Study

2005 ◽  
Vol 4 (3) ◽  
pp. 138-146 ◽  
Author(s):  
Thiboutot Diane M. ◽  
Shalita Alan R. ◽  
Yamauchi Paul S. ◽  
Dawson Catherine ◽  
Arsonnaud Stéphanie ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Acne Vulgaris ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Severe Acne ◽  
Randomized Controlled
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