A comparative study on the efficacy of fractional CO2 laser and fractional CO2 laser with autologous platelet-rich plasma in scars

Background:Striae distensae is a very common condition with irregularly linear, several centimetres long. There are numerous therapeutic modalities available with variable efficacy but none are proven treatment. A Aim and objectives: comparative study of Fractional CO2 Laser Versus Microneedling With Autologous platelet Rich Plasma in striae distensae. This study was conducted from november 2016–2017 and included 52 patients of striae dist Methods: ensae where Group-1 of striae treated by microneedling with autologous PRP and Group-2 treated with Fractional CO2 laser. Randomized prospective study was conducted for a period of 16 weeks. Clinical photographs were taken immediately before and 4 weeks after fourth treatment and VAS score and patient satisfaction score was obtained at the baseline and at the end of 20 weeks to see treatment response. As per the VAS system, mean VAS in the patients Gr Results: oup-1 treated by microneedling with prp was 0.8462± 0.3397 at 4 weeks, which later increased to 2.577± 0.6737 at 20th week i.e. 4 weeks after the last sitting. Mean VAS in patients Group-2 treated by Fractional co2 laser was 1.077±0.3374 at 4 weeks, which later increased to 3.077±0.7706 at 20th week i.e. 4 weeks after the last sitting.The difference in mean VAS at 4th week between two groups was statistically significant with a p-value of <0.05(0.0110). The difference in mean VAS at 20thth week between two groups was statistically significant with a p-value of <0.05(0.0100). Both groups of the patients showed statistically significant improvement in striae distensae at the end of 20th weeks however Fractional CO2 laser versus microneedling with autologous PRP was more efficacious in decreasing the extent of striae distensae. Conclusion:Study concluded microneedling with Autologous PRP, and Fractional CO2 Laser both can serve as a safe and efficient treatment in cases of striae distensae but fractional CO2 laser more efficaceous.

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Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20171224 ◽

2017 ◽

Vol 5 (4) ◽

pp. 1344 ◽

Cited By ~ 3

Author(s):

Sidhartha D. Shah ◽

Bipin D. Mehta ◽

Milind A. Borkar ◽

Reshma C. Aswani

Keyword(s):

Adverse Effects ◽

Injection Site ◽

Co2 Laser ◽

Normal Saline ◽

Platelet Rich Plasma ◽

Safety And Efficacy ◽

Fractional Co2 Laser ◽

Acne Scars ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

Background: Many treatments are available for treating post acne scars but optimized treatment does not exist still. Hence, this study was conducted with the aim to evaluate the safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser for treatment of acne scars when used in Indian skin.Methods: Thirty patients attended to the Dermatology OPD were enrolled in the study after meeting inclusion criteria. They underwent split-face therapy. They received ablative fractional carbon dioxide (CO2) laser combined with autologous platelet-rich plasma (PRP) treatment on one half of their face and ablative fractional CO2 laser with intradermal normal saline on the other half. The injections were administered immediately after laser therapy. Each participant received 4 treatments spaced by 1 month and were followed up for a period of 4 months.Results: The outcome among the study subjects were assessed using Goodman and Baron Scale at different time intervals. Significant reduction in acne scars was observed in both PRP injection site and normal saline injection site but better reduction of acne scars was noted at the PRP site. The blinded physician’s assessment and patient satisfaction was better at PRP injected side as compared to the normal saline injected side. The incidence of adverse effects and pain during the procedure was significantly lower in PRP injected side compared normal saline injected side.Conclusions: This study demonstrated that PRP should be considered as an adjuvant therapeutic option for dermatologic procedures such as fractional CO2 laser resurfacing for treatment of post acne scars as it might have additional benefit of reducing the adverse effects such as persistent erythema and edema.

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