Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study

Abstract Background Prevalence of active venous leg ulcers was reported to be around 0.5% in different populations severely reduces quality of life, and increases the cost of health care. Management of VLUs include many modalities to obtain good result and improving patients life-style, these modalities include compression therapy, medical treatment, surgical and interventional procedures and local wound care. Objective: To compare between autologous platelet rich plasma and saline dressing in treatment of chronic leg venous ulcer concerning reduction of ulcer area. Patients and Methods That prospective study included 40 patients with chronic venous leg ulcers recruited from Ain shams university hospitals for whom treatment with PRP was done for 20 patients weekly for up to 3 weeks(one session of injection per week)(study group) and applying saline dressing for 20 patients(control group) in addition to compression therapy and follow up for4 months. Our objective was to compare rate of wound healing. Results A total of 44 venous ulcers from 40 patients who met the inclusion criteria were treated. Application of PRP was done for 20 patients weekly for up to 3 weeks(one session of injection per week)(study group) and applying saline dressing for 20 patients(control group) in addition to compression therapy and follow up for4 months. Conclusion We can draw the conclusion our study's results reveal that the use of PRP contributes to improving the results of treatment of venous ulcers and that it is an effective and safe therapy. Nonetheless, we need to consider that application of this or any other treatment should always be accompanied by the necessary management of the underlying disease, in addition to a suitable pressure bandage that improves venous return and facilitates favourable clinical course of lesions.

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Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study

Journal of Wound Care ◽

10.12968/jowc.2018.27.sup6.s20 ◽

2018 ◽

Vol 27 (Sup6) ◽

pp. S20-S24 ◽

Cited By ~ 7

Author(s):

Natalia Burgos-Alonso ◽

Igone Lobato ◽

Igone Hernández ◽

Kepa San Sebastian ◽

Begoña Rodríguez ◽

...

Keyword(s):

Primary Care ◽

Pilot Study ◽

Platelet Rich Plasma ◽

Leg Ulcers ◽

Venous Leg Ulcers ◽

Autologous Platelet Rich Plasma ◽

Randomised Controlled ◽

Autologous Platelet

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AUTOLOGOUS PLATELET RICH PLASMA (PRP) VERSUS LEUCOCYTE-PLATELET RICH FIBRIN (L-PRF) IN CHRONIC NON-HEALING LEG ULCERS - A RANDOMISED, OPEN LABELLED, COMPARATIVE STUDY

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/1689 ◽

2016 ◽

Vol 5 (102) ◽

pp. 7460-7462 ◽

Cited By ~ 7

Author(s):

Azariah Johnson Samuel Pravin ◽

Sridhar V ◽

Balasubramanian Narayana Srinivasan

Keyword(s):

Comparative Study ◽

Platelet Rich Plasma ◽

Leg Ulcers ◽

Platelet Rich Fibrin ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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Cell therapy with autologous platelet rich plasma in the treatment of chronic venous leg ulcers. preliminary results of a prospective randomised phase 2 trial

Cytotherapy ◽

10.1016/j.jcyt.2018.02.348 ◽

2018 ◽

Vol 20 (5) ◽

pp. S117 ◽

Cited By ~ 1

Author(s):

G.E. Otero ◽

A. Sujanov ◽

S. Falco ◽

L. Echarte ◽

N. Lamela ◽

...

Keyword(s):

Cell Therapy ◽

Platelet Rich Plasma ◽

Leg Ulcers ◽

Phase 2 ◽

Preliminary Results ◽

Venous Leg Ulcers ◽

Phase 2 Trial ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series

Vascular ◽

10.1177/1708538114563824 ◽

2014 ◽

Vol 23 (6) ◽

pp. 580-585 ◽

Cited By ~ 6

Author(s):

Seyhan Yilmaz ◽

Eray Aksoy ◽

Suat Doganci ◽

Adnan Yalcinkaya ◽

Adem I Diken ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Case Series ◽

Leg Ulcers ◽

Wound Surface ◽

Wound Area ◽

Venous Leg Ulcers ◽

Venous Ulcers ◽

Autologous Platelet Rich Plasma ◽

Prospective Case Series ◽

Complete Wound Healing

StudyWe report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers.Material and methodsThere were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm2of the wound surface with half of the amount being injected 1–2 mm deep into the wound and the wound surface was covered with the remaining half.ResultsComplete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements.ConclusionPlatelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.

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