scholarly journals Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

2017 ◽  
Vol 5 (4) ◽  
pp. 1344 ◽  
Author(s):  
Sidhartha D. Shah ◽  
Bipin D. Mehta ◽  
Milind A. Borkar ◽  
Reshma C. Aswani
Keyword(s):  
Adverse Effects ◽  
Injection Site ◽  
Co2 Laser ◽  
Normal Saline ◽  
Platelet Rich Plasma ◽  
Safety And Efficacy ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Background: Many treatments are available for treating post acne scars but optimized treatment does not exist still. Hence, this study was conducted with the aim to evaluate the safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser for treatment of acne scars when used in Indian skin.Methods: Thirty patients attended to the Dermatology OPD were enrolled in the study after meeting inclusion criteria. They underwent split-face therapy. They received ablative fractional carbon dioxide (CO2) laser combined with autologous platelet-rich plasma (PRP) treatment on one half of their face and ablative fractional CO2 laser with intradermal normal saline on the other half. The injections were administered immediately after laser therapy. Each participant received 4 treatments spaced by 1 month and were followed up for a period of 4 months.Results: The outcome among the study subjects were assessed using Goodman and Baron Scale at different time intervals. Significant reduction in acne scars was observed in both PRP injection site and normal saline injection site but better reduction of acne scars was noted at the PRP site. The blinded physician’s assessment and patient satisfaction was better at PRP injected side as compared to the normal saline injected side. The incidence of adverse effects and pain during the procedure was significantly lower in PRP injected side compared normal saline injected side.Conclusions: This study demonstrated that PRP should be considered as an adjuvant therapeutic option for dermatologic procedures such as fractional CO2 laser resurfacing for treatment of post acne scars as it might have additional benefit of reducing the adverse effects such as persistent erythema and edema.

scholarly journals A comparative study on the efficacy of fractional CO2 laser and fractional CO2 laser with autologous platelet-rich plasma in scars

2020 ◽  
Vol 11 (6) ◽  
pp. 930
Author(s):  
Sandeep Arora ◽  
Satish Godara ◽  
Rajeshwari Dabas ◽  
Gulhima Arora ◽  
Gopi Renganathan ◽  
...  
Keyword(s):  
Comparative Study ◽  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals A PROSPECTIVE INTERVENTIONAL STUDY COMPARING THE EFFICACY OF FRACTIONAL CO2 LASER AND MICRONEEDLING COMBINED WITH AUTOLOGOUS PLATELET RICH PLASMA IN MANAGEMENT OF STRIAE DISTENSAE

2021 ◽  
pp. 57-60
Author(s):  
Sanjay Meena ◽  
Ashok Meherda ◽  
Rajkumar Kothiwala ◽  
Kapil Vyas
Keyword(s):  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
P Value ◽  
Striae Distensae ◽  
Patient Satisfaction Score ◽  
Efficient Treatment ◽  
Fractional Co2 Laser ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet

Background:Striae distensae is a very common condition with irregularly linear, several centimetres long. There are numerous therapeutic modalities available with variable efficacy but none are proven treatment. A Aim and objectives: comparative study of Fractional CO2 Laser Versus Microneedling With Autologous platelet Rich Plasma in striae distensae. This study was conducted from november 2016–2017 and included 52 patients of striae dist Methods: ensae where Group-1 of striae treated by microneedling with autologous PRP and Group-2 treated with Fractional CO2 laser. Randomized prospective study was conducted for a period of 16 weeks. Clinical photographs were taken immediately before and 4 weeks after fourth treatment and VAS score and patient satisfaction score was obtained at the baseline and at the end of 20 weeks to see treatment response. As per the VAS system, mean VAS in the patients Gr Results: oup-1 treated by microneedling with prp was 0.8462± 0.3397 at 4 weeks, which later increased to 2.577± 0.6737 at 20th week i.e. 4 weeks after the last sitting. Mean VAS in patients Group-2 treated by Fractional co2 laser was 1.077±0.3374 at 4 weeks, which later increased to 3.077±0.7706 at 20th week i.e. 4 weeks after the last sitting.The difference in mean VAS at 4th week between two groups was statistically significant with a p-value of <0.05(0.0110). The difference in mean VAS at 20thth week between two groups was statistically significant with a p-value of <0.05(0.0100). Both groups of the patients showed statistically significant improvement in striae distensae at the end of 20th weeks however Fractional CO2 laser versus microneedling with autologous PRP was more efficacious in decreasing the extent of striae distensae. Conclusion:Study concluded microneedling with Autologous PRP, and Fractional CO2 Laser both can serve as a safe and efficient treatment in cases of striae distensae but fractional CO2 laser more efficaceous.

Split face comparative study of microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Abd Elnaeem Sallam ◽  
Khaled El Zawahry ◽  
Abdul Rahman Muhammed Ali Mustafa
Keyword(s):  
Carbon Dioxide ◽  
Co2 Laser ◽  
Carbon Dioxide Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Significant Difference ◽  
Before And After ◽  
The Face ◽  
Fractional Carbon Dioxide Laser

Abstract Background Acne scars, is a challenge for dermatologists, despite having multiple treatment modalities like microneedling, dermabrasion, Fractional CO2 Laser, dermal fillers, etc. However, monotherapy has been hardly satisfactory because of the polymorphism seen with the scars. Objective Comparison between microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars. Patients and methods This study was carried out in department of dermatology, venereology and andrology, in Kobry El-Kobba Military complex during the period (from September 2018 to July 2020 ) on 20 patients of both sexes aged from 20 to 60 years old presenting with Goodman and Baron Grade II, III, IV acne scars . Results The study revealed a statistically significant difference (p = 0.017) between Goodman and Baron scar grades on the right side of the face before and after treatment indicating that microneedling with platelet rich plasma was effective in improving acne scars. Also, there is a statistically significant difference (p = 0.010) between Goodman and Baron scar grades on the left side of the face before and after treatment, indicating that fractional CO2 laser with platelet rich plasma was effective in improving acne scars. Conclusion and recommendation Further controlled and randomized studies are needed to validate our findings in a larger cohort of patients and longer follow up. Also, number of sessions might be more than 3 sessions.

scholarly journals The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne

2013 ◽  
Vol 8 (1) ◽  
pp. 233-237 ◽  
Author(s):  
JIANG-TING ZHU ◽  
MIN XUAN ◽  
YA-NI ZHANG ◽  
HONG-WEI LIU ◽  
JIN-HUI CAI ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Platelet Rich Plasma ◽  
Fractional Laser ◽  
Acne Scars ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Facial Acne
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