scholarly journals A PROSPECTIVE INTERVENTIONAL STUDY COMPARING THE EFFICACY OF FRACTIONAL CO2 LASER AND MICRONEEDLING COMBINED WITH AUTOLOGOUS PLATELET RICH PLASMA IN MANAGEMENT OF STRIAE DISTENSAE

2021 ◽  
pp. 57-60
Author(s):  
Sanjay Meena ◽  
Ashok Meherda ◽  
Rajkumar Kothiwala ◽  
Kapil Vyas
Keyword(s):  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
P Value ◽  
Striae Distensae ◽  
Patient Satisfaction Score ◽  
Efficient Treatment ◽  
Fractional Co2 Laser ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet

Background:Striae distensae is a very common condition with irregularly linear, several centimetres long. There are numerous therapeutic modalities available with variable efficacy but none are proven treatment. A Aim and objectives: comparative study of Fractional CO2 Laser Versus Microneedling With Autologous platelet Rich Plasma in striae distensae. This study was conducted from november 2016–2017 and included 52 patients of striae dist Methods: ensae where Group-1 of striae treated by microneedling with autologous PRP and Group-2 treated with Fractional CO2 laser. Randomized prospective study was conducted for a period of 16 weeks. Clinical photographs were taken immediately before and 4 weeks after fourth treatment and VAS score and patient satisfaction score was obtained at the baseline and at the end of 20 weeks to see treatment response. As per the VAS system, mean VAS in the patients Gr Results: oup-1 treated by microneedling with prp was 0.8462± 0.3397 at 4 weeks, which later increased to 2.577± 0.6737 at 20th week i.e. 4 weeks after the last sitting. Mean VAS in patients Group-2 treated by Fractional co2 laser was 1.077±0.3374 at 4 weeks, which later increased to 3.077±0.7706 at 20th week i.e. 4 weeks after the last sitting.The difference in mean VAS at 4th week between two groups was statistically significant with a p-value of <0.05(0.0110). The difference in mean VAS at 20thth week between two groups was statistically significant with a p-value of <0.05(0.0100). Both groups of the patients showed statistically significant improvement in striae distensae at the end of 20th weeks however Fractional CO2 laser versus microneedling with autologous PRP was more efficacious in decreasing the extent of striae distensae. Conclusion:Study concluded microneedling with Autologous PRP, and Fractional CO2 Laser both can serve as a safe and efficient treatment in cases of striae distensae but fractional CO2 laser more efficaceous.

scholarly journals A comparative study on the efficacy of fractional CO2 laser and fractional CO2 laser with autologous platelet-rich plasma in scars

2020 ◽  
Vol 11 (6) ◽  
pp. 930
Author(s):  
Sandeep Arora ◽  
Satish Godara ◽  
Rajeshwari Dabas ◽  
Gulhima Arora ◽  
Gopi Renganathan ◽  
...  
Keyword(s):  
Comparative Study ◽  
Co2 Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-faces study

2017 ◽  
Vol 5 (4) ◽  
pp. 1344 ◽  
Author(s):  
Sidhartha D. Shah ◽  
Bipin D. Mehta ◽  
Milind A. Borkar ◽  
Reshma C. Aswani
Keyword(s):  
Adverse Effects ◽  
Injection Site ◽  
Co2 Laser ◽  
Normal Saline ◽  
Platelet Rich Plasma ◽  
Safety And Efficacy ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Background: Many treatments are available for treating post acne scars but optimized treatment does not exist still. Hence, this study was conducted with the aim to evaluate the safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser for treatment of acne scars when used in Indian skin.Methods: Thirty patients attended to the Dermatology OPD were enrolled in the study after meeting inclusion criteria. They underwent split-face therapy. They received ablative fractional carbon dioxide (CO2) laser combined with autologous platelet-rich plasma (PRP) treatment on one half of their face and ablative fractional CO2 laser with intradermal normal saline on the other half. The injections were administered immediately after laser therapy. Each participant received 4 treatments spaced by 1 month and were followed up for a period of 4 months.Results: The outcome among the study subjects were assessed using Goodman and Baron Scale at different time intervals. Significant reduction in acne scars was observed in both PRP injection site and normal saline injection site but better reduction of acne scars was noted at the PRP site. The blinded physician’s assessment and patient satisfaction was better at PRP injected side as compared to the normal saline injected side. The incidence of adverse effects and pain during the procedure was significantly lower in PRP injected side compared normal saline injected side.Conclusions: This study demonstrated that PRP should be considered as an adjuvant therapeutic option for dermatologic procedures such as fractional CO2 laser resurfacing for treatment of post acne scars as it might have additional benefit of reducing the adverse effects such as persistent erythema and edema.

scholarly journals ON IMPROVING THE TREATMENT OF PATIENTS WITH CHRONIC WOUNDS OF VENOUS GENESIS

2019 ◽  
Vol 19 (3) ◽  
pp. 75-78
Author(s):  
Ya.V. Rybalka
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Wound Area ◽  
Area Reduction ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet ◽  
Group 1

Introduction. The analysis of the effectiveness of applying autologous platelet-rich plasma was performed in order to improve the results of surgical treatment of patients with wounds that heal slowly. Materials. The study is based on the analysis of the treatment of 61 patients who suffered from slow-healing wounds of venous genesis with a diameter of no more than 8 cm on the lower extremities and took the treatment at the surgical ward. The proposed method was based on obtaining autologous enriched platelet plasma followed by its injection along the periphery of the wound. The degree of reduction of the wound surface area was assessed by the method of contact planimetry per day. The patients of the 1st group demonstrated the wound area reduction by 5.1 ± 0.6%, and the patients of the group 2 – by 1.8 ± 0.4% (p <0005). The results indicate an increase in the rate of wound healing in patients in group 1 compared with patients in group 2. During the entire follow-up period (12 weeks), complete wound epithelialisation occurred in 21 (70%) patients in group 1 and in 10 (33.3%) patients of the group 2. The wound area decreased by more than 50% in 6 patients of group 1 (20%) and in 2 (7%) patients of the control group. The wound area decreased less than by 50% in 3 patients in group 1 (10%), and in 19 patients in group 2 (60%). The use of PRP therapy has been proven to have a significant positive effect on the process of wound healing compared with the use of standard methods used for the control group. Conclusion: increase in the wound healing pace in patients of group 1 (test) compared with patients of group 2 (control) can be explained by using autologous platelet-enriched plasma as an additional means to the standard therapy.

Efficacy of intradermal radiofrequency combined with autologous platelet-rich plasma in striae distensae: a pilot study

2012 ◽  
Vol 51 (10) ◽  
pp. 1253-1258 ◽  
Author(s):  
In Su Kim ◽  
Kui Young Park ◽  
Beom Joon Kim ◽  
Myeung Nam Kim ◽  
Chan Woong Kim ◽  
...  
Keyword(s):  
Pilot Study ◽  
Platelet Rich Plasma ◽  
Striae Distensae ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Improved Posterolateral Lumbar Spinal Fusion Using a Biomimetic, Nanocomposite Scaffold Augmented by Autologous Platelet-Rich Plasma

2021 ◽  
Vol 9 ◽  
Author(s):  
Jeffrey L. Van Eps ◽  
Joseph S. Fernandez-Moure ◽  
Fernando J. Cabrera ◽  
Francesca Taraballi ◽  
Francesca Paradiso ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Platelet Rich Plasma ◽  
Bone Volume ◽  
Lumbar Spinal Fusion ◽  
Orthotopic Model ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Lumbar Spinal ◽  
Autologous Platelet ◽  
Group 1

Remodeling of the human bony skeleton is constantly occurring with up to 10% annual bone volume turnover from osteoclastic and osteoblastic activity. A shift toward resorption can result in osteoporosis and pathologic fractures, while a shift toward deposition is required after traumatic, or surgical injury. Spinal fusion represents one such state, requiring a substantial regenerative response to immobilize adjacent vertebrae through bony union. Autologous bone grafts were used extensively prior to the advent of advanced therapeutics incorporating exogenous growth factors and biomaterials. Besides cost constraints, these applications have demonstrated patient safety concerns. This study evaluated the regenerative ability of a nanostructured, magnesium-doped, hydroxyapatite/type I collagen scaffold (MHA/Coll) augmented by autologous platelet-rich plasma (PRP) in an orthotopic model of posterolateral lumbar spinal fusion. After bilateral decortication, rabbits received either the scaffold alone (Group 1) or scaffold with PRP (Group 2) to the anatomic right side. Bone regeneration and fusion success compared to internal control were assessed by DynaCT with 3-D reconstruction at 2, 4, and 6 weeks postoperatively followed by comparative osteogenic gene expression and representative histopathology. Both groups formed significantly more new bone volume than control, and Group 2 subjects produced significantly more trabecular and cortical bone than Group 1 subjects. Successful fusion was seen in one Group 1 animal (12.5%) and 6/8 Group 2 animals (75%). This enhanced effect by autologous PRP treatment appears to occur via astounding upregulation of key osteogenic genes. Both groups demonstrated significant gene upregulation compared to vertebral bone controls for all genes. Group 1 averaged 2.21-fold upregulation of RUNX2 gene, 3.20-fold upregulation of SPARC gene, and 3.67-fold upregulation of SPP1 gene. Depending on anatomical subgroup (cranial, mid, caudal scaffold portions), Group 2 had significantly higher average expression of all genes than both control and Group 1–RUNX2 (8.23–19.74 fold), SPARC (18.67–55.44 fold), and SPP1 (46.09–90.65 fold). Our data collectively demonstrate the osteoinductive nature of a nanostructured MHA/Coll scaffold, a beneficial effect of augmentation with autologous PRP, and an ability to achieve clinical fusion when applied together in an orthotopic model. This has implications both for future study and biomedical innovation of bone-forming therapeutics.

scholarly journals A comparative study between platelet rich plasma and conventional dressing in chronic non healing leg ulcers

2020 ◽  
Vol 7 (3) ◽  
pp. 751
Author(s):  
Ramakrishna Reddy Gade ◽  
Venkata Reddy M. ◽  
Padmanabh Inamdar
Keyword(s):  
Wound Healing ◽  
Normal Saline ◽  
Platelet Rich Plasma ◽  
P Value ◽  
Leg Ulcers ◽  
Major Health Problem ◽  
Ulcer Size ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Background: Chronic non-healing leg ulcers are a major health problem worldwide and have great impact on personal, professional and social levels, with high cost in terms of human and material resources. The present study was conducted with an aim to demonstrate the efficacy of autologous platelet rich plasma (PRP) in chronic non-healing leg ulcers in comparison to conventional dressings.Methods: A total of 50 patients with leg ulcers were randomized into two groups (A and B) with each group comprising of 25 patients each. Group A were treated with autologous platelet rich plasma (PRP) dressings and group B were treated with conventional dressings using normal saline. Ulcer measurements were taken on day 1, day 7, days 15 and after 30 days. The end point of study was complete wound epithelialization or appearance of granulation tissue, which ultimately lead to spilt skin grafting or secondary healing; whichever is earlier.Results: There was statistically significant difference in the average time taken for complete healing of ulcer in PRP dressings, 3.68 weeks against 6.2 weeks in conventional dressing group (p value <0.0001). PRP dressing group showed a 43.96% reduction in ulcer size as compared to 13.81% in conventional dressing group (p <0.0001). It was observed that PRP dressing group has faster wound healing and contraction of wound.Conclusions: PRP dressing of leg ulcers was better than conventional normal saline dressing as it leads to early reduction of ulcer size and enhances rate of wound healing. 

Efficacy of topical application of autologous platelet-rich plasma in adult tonsillectomy patients: a randomised control study

2021 ◽  
pp. 1-6
Author(s):  
S Nanditha ◽  
S Gopalakrishnan ◽  
P Karthikeyan ◽  
S Singh Bakshi
Keyword(s):  
Platelet Rich Plasma ◽  
Normal Activity ◽  
Recurrent Tonsillitis ◽  
Chi Square ◽  
Activity Data ◽  
Significance Level ◽  
Chi Square Test ◽  
Autologous Platelet Rich Plasma ◽  
Group 2 ◽  
Autologous Platelet

Abstract Objective Tonsillectomy is a painful surgery performed in cases of recurrent tonsillitis. Application of platelet-rich plasma to diminish the pain and morbidity post-tonsillectomy is gaining importance. This study evaluated post-operative pain and morbidity after autologous platelet-rich plasma application on the tonsil beds during tonsillectomy. Method Participants were randomised into group 1 (n = 28, peri-operative platelet-rich plasma intervention) and group 2 (n = 28, control). Post-tonsillectomy, patients were assessed (day 0, 1, 2, 3, 7 and 14) for pain, healing and time taken to return to normal activity. Data were analysed by independent t-test and chi-square test with p ≤ 0.05 as the significance level. Results A significant decrease in the mean pain score up to day 7 (p < 0.05) and tonsillar fossae healing on days 2 and 3 (p < 0.05) post-tonsillectomy was noted. The majority of the patients returned to their routine activities after a week post-tonsillectomy. Conclusion Platelet-rich plasma application was effective in accentuating healing and reducing post-tonsillectomy pain and morbidity.

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