The utility of ancillary techniques in the cyto-diagnosis of malignant scalp lesions

Topical corticosteroids are commonly used for the short-term management of seborrhoeic dermatitis (SD) of the scalp. The aim of this study was to evaluate the effectiveness, tolerance and cosmetic acceptability of desonide 0.05% solution, whose alcohol-free formulation is innovative with respect to traditional corticosteroid lotions, in the treatment of SD of the scalp. For this purpose, 155 adult subjects applied on scalp lesions desonide once daily for 1 week, on alternate days for 3 weeks, and two times a week for 4 weeks. A significant reduction of the severity of erythema, scaling and pruritus was observed (P<0.001). Interestingly, during the phase of gradual reduction of weekly applications, results were frequently maintained or improved further. Twenty patients (13%) at 4 weeks and 85 patients (58%) at 8 weeks had their scalp SD cleared. Most patients regarded the overall effectiveness, tolerability and acceptability as satisfactory; patients who had previously used common steroid lotions expressed a positive judgment on desonide solution compared to the other lotions in terms of efficacy, acceptability, rapidity of action, tolerability and persistence of effects. In conclusion, our preliminary findings indicate that desonide 0.05% solution is suitable for the short-term management of scalp SD.

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The Significance of Scalp Involvement in Pemphigus: A Literature Review

BioMed Research International ◽

10.1155/2018/6154397 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Marta Sar-Pomian ◽

Lidia Rudnicka ◽

Malgorzata Olszewska

Keyword(s):

Web Of Science ◽

Clinical Manifestations ◽

Pemphigus Vulgaris ◽

Hair Follicles ◽

Response To Treatment ◽

Direct Immunofluorescence ◽

Pemphigus Foliaceus ◽

Medical Databases ◽

Scalp Lesions ◽

Reliable Diagnostic Method

Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp. Trichoscopy may serve as a supplementary method in the diagnosis of pemphigus. This review summarizes the most recent data concerning scalp involvement in pemphigus vulgaris and pemphigus foliaceus. A systematic literature search was conducted in three medical databases: PubMed, Embase, and Web of Science. The analysis included literature data about desmoglein distribution in hair follicles, as well as information about clinical manifestations, histopathology, immunopathology, and trichoscopy of scalp lesions in pemphigus and their response to treatment.

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Nannizzia obtusa. [Descriptions of Fungi and Bacteria].

IMI Descriptions of Fungi and Bacteria ◽

10.1079/dfb/20056400070 ◽

1965 ◽

Author(s):

P. M. Stockdale

Keyword(s):

New Zealand ◽

North America ◽

Central America ◽

Geographical Distribution ◽

West Indies ◽

Tinea Capitis ◽

World Wide ◽

Whole Body ◽

Scalp Lesions ◽

Light Green

Abstract A description is provided for Nannizzia obtusa. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Primarily a pathogen of the pig, occasionally transmitted to man. Guinea-pigs have been experimentally infected. DISEASE: Ringworm (dermatophytosis, tinea). In pigs lesions are circular and circumscribed to irregular in outline, sometimes involving almost the whole body. They are reddish in colour and are frequently covered with brownish crusts. Alopecia and pruritis do not occur (RMVM 5, 226, 491-492). In man the scalp (tinea capitis) and glabrous skin (tinea corporis) may be infected. Scalp lesions reported have shown a kerion type of reaction with endothrix hair invasion; in some cases infected hairs have fluoresced light green under Wood's light. GEOGRAPHICAL DISTRIBUTION: Reported from Africa (Kenya), Australasia (Australia, New Zealand); North America (Canada, U.S.A. (Ind., Kans., Ky, Miss., N.J., Pa)), Central America and West Indies (Mexico, Cuba). Possibly world-wide in distribution.

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