Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

Abstract Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CG levels. Normal values for immunochemically reactive CG during the first trimester of pregnancy are given. Serial determinations of CG have diagnostic value in assessing various abnormal pregnancy states. An abnormally increased urinary output of CG is observed in some neoplasms—e.g., chorionepithelioma, and a rapidly rising CG level is strongly suggestive of molar pregnancy. Urinary CG levels falling below the normal range mayindicate an ectopic pregnancy or an inevitable, incomplete, or "missed" abortion. The immunochemical CG determination also offers a sensitive, simple, and convenient routine method for following patients who have been treated for hydatidiformmole or chorionepithelioma.

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A comparison of anesthetic regimens using etomidate and propofol in patients undergoing first-trimester abortions: double-blind, randomized clinical trial of safety and efficacy

Contraception ◽

10.1016/j.contraception.2012.08.014 ◽

2013 ◽

Vol 87 (1) ◽

pp. 55-62 ◽

Cited By ~ 14

Author(s):

Jing Wu ◽

Shanglong Yao ◽

Zhouyang Wu ◽

Zhiling Wu ◽

Shujuan Chu ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

First Trimester ◽

Double Blind ◽

Safety And Efficacy

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Intramuscular ketorolac versus oral ibuprofen for pain relief in first-trimester surgical abortion: a randomized clinical trial

Contraception ◽

10.1016/j.contraception.2013.10.009 ◽

2014 ◽

Vol 89 (2) ◽

pp. 116-121 ◽

Cited By ~ 10

Author(s):

Kari P. Braaten ◽

Shelley Hurwitz ◽

Jennifer Fortin ◽

Alisa B. Goldberg

Keyword(s):

Clinical Trial ◽

Pain Relief ◽

Randomized Clinical Trial ◽

First Trimester ◽

Oral Ibuprofen ◽

Surgical Abortion ◽

Intramuscular Ketorolac

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Randomized clinical trial comparing percutaneous closure of patent foramen ovale (PFO) using the Amplatzer PFO Occluder with medical treatment in patients with cryptogenic embolism (PC-Trial): rationale and design

Trials ◽

10.1186/1745-6215-12-56 ◽

2011 ◽

Vol 12 (1) ◽

Cited By ~ 14

Author(s):

Ahmed A Khattab ◽

Stephan Windecker ◽

Peter Jüni ◽

David Hildick-Smith ◽

Dariusz Dudek ◽

...

Keyword(s):

Clinical Trial ◽

Medical Treatment ◽

Randomized Clinical Trial ◽

Patent Foramen Ovale ◽

Percutaneous Closure ◽

Foramen Ovale

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Exposure to Propylthiouracil in the First Trimester of Pregnancy and Birth Defects: A Study at a Single Institution

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa204 ◽

2021 ◽

Vol 5 (3) ◽

Author(s):

Ai Yoshihara ◽

Jaeduk Yoshimura Noh ◽

Natsuko Watanabe ◽

Miho Fukushita ◽

Masako Matsumoto ◽

...

Keyword(s):

Medical Treatment ◽

Birth Defects ◽

Antithyroid Drug ◽

First Trimester ◽

Control Group ◽

Graves Disease ◽

Increased Risk ◽

Group A ◽

First Trimester Of Pregnancy ◽

Maternal Thyroid

Abstract Context Medical treatment of Graves disease during the first trimester has been the subject of controversy ever since treatment with an antithyroid drug during the first trimester was reported to possibly be associated with an increased risk of birth defects in newborns. Objective We investigated whether the incidence of birth defects among newborns born to mothers with Graves disease (GD) treated with propylthiouracil (PTU) during the first trimester of pregnancy was higher than in a control group that was not exposed to any medication. Methods We reviewed the cases of 1913 women with GD who gave birth between January 1, 2015, and May 31, 2019. Detailed information concerning the outcome of pregnancy and the presence of birth defects was collected at the first visit after the delivery and again 1 year after delivery. We classified the mothers and infants into 3 groups according to the treatment the mother had received for GD in the first trimester of pregnancy: a group in which the mothers had been treated with PTU alone (PTU group), a group in which the mothers had not been treated with any medication (control group), and a group in which the mothers had received some other medical treatment, such as thiamazole, potassium iodide, or 2 or more drugs (other treatment group). Results The incidence of malformed infant births was 5.5% (30/541 infants) in the PTU group and 5.7% (27/ 475 infants) in the control group. There were no specific birth defects in the PTU group, and there were no significant differences between PTU dosages or maternal thyroid function according to whether mothers had delivered a child with a birth defect. Conclusion The results of our retrospective study showed that treatment with PTU during the first trimester of pregnancy did not increase the incidence of birth defects among newborns.

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