scholarly journals Reference values of dorsal sural sensory nerve action potential: A useful tool to diagnose peripheral neuropathy

2021 ◽  
Vol 12 (1) ◽  
pp. 13
Author(s):  
SunilKumar Jena ◽  
Manoranjan Acharya
Keyword(s):  
Peripheral Neuropathy ◽  
Action Potential ◽  
Reference Values ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action

Lack of peripheral neuropathy in Beagle dogs after 53 weeks oral administration of thalidomide capsules

2000 ◽  
Vol 19 (11) ◽  
pp. 615-622 ◽  
Author(s):  
S Teo ◽  
M Evans ◽  
J Ehrhart ◽  
M Brockman ◽  
D Allen ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Action Potential ◽  
Sural Nerve ◽  
Recovery Period ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Beagle Dogs ◽  
Toxicology Study ◽  
Nerve Action ◽  
Sensory Nerve Action

Thalidomide (Thalomid®) is approved for use in the US to treat complications from leprosy. Peripheral neuropathy is a dose-limiting adverse event in humans. As part of a nonrodent regulatory toxicology study, Beagle dogs were fed orally via encapsulation for 53 weeks. A component of this study was to determine if the dogs developed peripheral neuropathy. Twenty-eight male and 28 female Beagle dogs approximately 8-10 months of age were used. They were dosed at 43, 200 or 1000 mg/kg for 53 weeks followed by a 4-week treatment-free recovery period. Nerve function was assessed by electrophysiological measurements of the tibial nerve prior to dosing and at weeks 13, 27, 38 and 51. Representative dogs from each group were sacrificed at 26, 53 and 58 weeks and histologic and ultrastructural evaluations were performed on the sural nerve. Thali-domide had no effect on sensory nerve conduction velocity, duration or amplitude of the action potential. At 27 weeks, mean sensory nerve action potential amplitude for females at 43 mg/kg was significantly greater than control but was not evident at 39 weeks. Mean duration of sensory nerve action potential seemed to increase with similar magnitude over time in all dose groups including controls. Histological and ultrastructural evaluation of sections of sural nerve did not identify treatment-induced differences between control and thalidomide-dosed animals after 26 and 53 weeks of treatment. Additionally, no differences were observed following a 5-week treatment-free period at week 58. In contrast to humans, Beagle dogs did not develop thalidomide-induced peripheral neuropathy under conditions of the study.

scholarly journals Dorsal sural sensory nerve action potential: A study for reference values

2017 ◽  
Vol 20 (2) ◽  
pp. 127
Author(s):  
SwetaChetan Chaudhari ◽  
KhushnumaAnil Mansukhani ◽  
Alika Sharma ◽  
Lajita Balakrishnan ◽  
Aarthika Sreenivasan
Keyword(s):  
Action Potential ◽  
Reference Values ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action

scholarly journals Electrophysiological diagnosis using sensory nerve action potential for the intraforaminal and extraforaminal L5 nerve root entrapment

2012 ◽  
Vol 22 (4) ◽  
pp. 833-839 ◽  
Author(s):  
Muneharu Ando ◽  
Tetsuya Tamaki ◽  
Mamoru Kawakami ◽  
Akihito Minamide ◽  
Yukihiro Nakagawa ◽  
...  
Keyword(s):  
Action Potential ◽  
Nerve Root ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action ◽  
Nerve Root Entrapment

Close relationship between cardiovagal function and sural sensory nerve action potential in type 2 diabetes

2019 ◽  
Vol 130 (7) ◽  
pp. 1160-1165
Author(s):  
Yun-Ru Lai ◽  
Chih-Cheng Huang ◽  
Wen-Chan Chiu ◽  
Rue-Tsuan Liu ◽  
Nai-Wen Tsai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Close Relationship ◽  
Sensory Nerve Action

83. Assessment of C7 nerve distribution with sensory nerve action potential after total C7 nerve transection

2009 ◽  
Vol 120 (2) ◽  
pp. e112-e113
Author(s):  
J. Xu ◽  
A. Mar ◽  
J. Lu ◽  
X. Jin ◽  
D. Zhu ◽  
...  
Keyword(s):  
Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Transection ◽  
Nerve Action ◽  
Sensory Nerve Action

Asymmetric sensory nerve action potential amplitudes as an early hint for diagnosing Lewis–Sumner syndrome

2016 ◽  
Vol 117 (2) ◽  
pp. 565-567
Author(s):  
Mehmet Ilker Yon ◽  
Hafize Nalan Gunes ◽  
Burcu Gokce Cokal ◽  
Selda Keskin Guler ◽  
Tahir Kurtulus Yoldas
Keyword(s):  
Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Nerve Action ◽  
Sensory Nerve Action
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