scholarly journals Human Herpesvirus 8-Negative and Epstein-Barr Virus-Positive Effusion-Based Lymphoma in a Patient with Human Immunodeficiency Virus

2015 ◽  
Vol 49 (5) ◽  
pp. 409-412 ◽  
Author(s):  
Jung-Woo Choi ◽  
Younghye Kim ◽  
Ju-Han Lee ◽  
Young-Sik Kim
1997 ◽  
Vol 175 (6) ◽  
pp. 1324-1332 ◽  
Author(s):  
Jennifer Webster‐Cyriaque ◽  
Rachel H. Edwards ◽  
Evelyn B. Quinlivan ◽  
Lauren Patton ◽  
David Wohl ◽  
...  

2006 ◽  
Vol 70 (11) ◽  
pp. 1923-1927 ◽  
Author(s):  
Cristiano Aparecido Chagas ◽  
Luiza Hayashi Endo ◽  
Washington Luís Conrado dos-Santos ◽  
Glauce Aparecida Pinto ◽  
Eulália Sakano ◽  
...  

2000 ◽  
Vol 124 (9) ◽  
pp. 1324-1330 ◽  
Author(s):  
Yotis F. Tsaparas ◽  
Malcolm L. Brigden ◽  
Richard Mathias ◽  
Eva Thomas ◽  
Janet Raboud ◽  
...  

Abstract Objectives.—To determine the proportion of patients with evidence of an acute infection due to Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), Toxoplasma, or human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) in heterophile-negative patients with an absolute lymphocytosis or an instrument-generated atypical lymphocyte flag, and to develop a cost-effective testing algorithm for managing such heterophile-negative patients. Design.—We conducted a prospective investigation of 70 selected outpatients who tested negative for heterophile antibody in association with an absolute lymphocytosis or instrument-generated atypical lymphocyte flag. The control population consisted of 50 patients who were heterophile negative and had a normal absolute lymphocyte count and no instrument-generated atypical lymphocyte flag. Setting.—A large outpatient laboratory system. Intervention.—Viral serology for HHV-6 was performed by immunofluorescence, and all other serologies were performed by enzyme-linked immunoassay. All testing was for immunoglobulin (Ig) M antibodies, except in the case of HIV. Results.—The proportion of study patients positive for EBV was 40% (28/70); for CMV, 39% (27/70); for HHV-6, 25% (16/65); for Toxoplasma, 3% (2/70); and for HIV, 0% (0/70). All 50 control patients were negative for EBV IgM antibodies. When patients with more than 1 positive viral test were excluded from analysis, positivity was 20% (9/45) for EBV, 22% (10/45) for CMV, 9% (4/45) for HHV-6, and 2% (1/45) for Toxoplasma. Utilizing hypothesis-generating logistic regression models, Downey type II atypical lymphocytes were significantly associated with EBV positivity (P = .006), while Downey type III lymphocytes were significantly associated with HHV-6 positivity (P = .016), and there was a trend for the association of Downey type I lymphocytes with CMV positivity (P = .097). Conclusions.—A positive viral serology was identified in 70% of study patients. Multiple positive serologies complicate establishing a definitive diagnosis. Potential cost savings may be associated with the use of an appropriate testing algorithm.


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