Bone Marrow Diseases

2012 ◽  
Author(s):  
Claudia Winograd
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Diseases

scholarly journals BONE MARROW LESIONS: DIAGNOSIS WITHOUT BIOPSY

2019 ◽  
pp. 19-25
Author(s):  
Yu. V. Nazinkina
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Diffusion Weighted Imaging ◽  
Pulse Sequence ◽  
Pulse Sequences ◽  
Bone Marrow Lesions ◽  
Bone Marrow Diseases ◽  
Standard Pulse ◽  
Spinal Mri ◽  
And Diffusion

Routine spinal MRI can be used for bone marrow lesions detection. The most useful standard pulse sequence is T1- WI, which helps both in local and diffuse bone marrow diseases. Additional new pulse sequences, including chemical shift imaging and diffusion weighted imaging, can be used as solving-problem techniques.

Magnetic Resonance Imaging in Diffuse Malignant Bone Marrow Diseases

1987 ◽  
Vol 28 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Rickard Nyman ◽  
S. Rehn ◽  
B. Glimelius ◽  
H. Hagberg ◽  
A. Hemmingsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Bone Marrow Diseases

A Common Genetic Mechanism in Malignant Bone Marrow Diseases

2009 ◽  
Vol 360 (22) ◽  
pp. 2355-2357 ◽  
Author(s):  
Ross L. Levine ◽  
Martin Carroll
Keyword(s):  
Bone Marrow ◽  
Genetic Mechanism ◽  
Bone Marrow Diseases

scholarly journals Factors associated with erythropoiesis-stimulating agent hyporesponsiveness anemia in chronic kidney disease patients.

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Kamalas Amnuay ◽  
Nattachai Srisawat ◽  
Kitsada Wudhikarn ◽  
Thamathorn Assanasen ◽  
Chantana Polprasert
Keyword(s):  
Chronic Kidney Disease ◽  
Bone Marrow ◽  
Kidney Disease ◽  
Pure Red Cell Aplasia ◽  
Serum Phosphate ◽  
Red Cell ◽  
Factors Associated ◽  
Bone Marrow Diseases ◽  
Bone Marrow Study ◽  
Common Problems

Anemia is one of the most common problems in chronic kidney disease (CKD). In several cases, despite comprehensive investigations, definite causes of anemia frequently remain unknown. We aimed to analyze the factors that possibly affect anemia in CKD patients who were referred for hematology consultation. A total of 87 patients were retrospectively included in the cohort. Forty-four cases were excluded, 30 cases with unavailable intact parathyroid hormone (iPTH) data, 11 cases with bone marrow diseases (8 Pure red cell aplasia, 3 Myelodysplastic syndrome) and 3 cases with thalassemia. Totally, 43 patients were analyzed. Patients with high iPTH had significantly lower Hemoglobin (Hb) level and required higher dose of erythropoietin stimulating agents (ESAs) compared with normal iPTH group (Hb 8.29 vs 9.24 mg/dL, p=0.032 and ESAs dose of 16,352.94 vs. 12,444.44 U/ week, p=0.024). In univariate followed by stepwise multivariate analysis, serum phosphate (PO4) was significantly associated with lower Hb level (p=0.01 and p=0.013, respectively). Hb level was inversely correlated with iPTH and PO4 level (r=-0.54, p<0.001 and r=-0.47, p=0.05; respectively). Mineral disequilibrium is an important factor associated with anemia in ESA hyporesponsive CKD. Hyperphosphatemia and secondary hyperparathyroidism are significantly correlated with low Hb. Therefore, we strongly suggest correction of these mineral disequilibrium factors prior to performing bone marrow study.

Stromal abnormalities in neoplastic bone marrow diseases

1996 ◽  
Vol 73 (2) ◽  
pp. 53-70 ◽  
Author(s):  
U. Dührsen ◽  
D. K. Hossfeld
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Diseases

Pathomechanism and clinical impact of myelofibrosis in neoplastic diseases of the bone marrow

2014 ◽  
Vol 155 (10) ◽  
pp. 367-375
Author(s):  
Judit Bedekovics ◽  
Gábor Méhes
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Mesenchymal Cells ◽  
Pathological Process ◽  
Cellular Interactions ◽  
Neoplastic Diseases ◽  
Bone Marrow Diseases ◽  
Extracellular Matrix Components ◽  
Reticular Cells ◽  
Basic Features

Polyclonal mesenchymal cells (fibroblasts, endothelial cells, pericytes, osteoblasts, reticular cells, adipocytes, etc.) of the bone marrow create a functional microenvironment, which actively contributes to the maintenance of hemopoesis. This takes place through cellular interactions via growth factors, cytokines, adhesion molecules and extracellular matrix components, as well as through the control of calcium and oxygen concentration. Inflammatory and neoplastic diseases of the bone marrow result in pathologic interaction between hemopoietic progenitors and stromal cells. This may lead to the activation and expansion of the stroma and to the accumulation of reticulin and collagen fibers produced by mesenchymal cells. Clinically relevant fiber accumulation, termed as myelofibrosis accompanies many diseases, although, the extent and the consequence of myelofibrosis are variable in different disorders. The aim of this review is to summarize basic features of the normal bone marrow mesenchymal environment and the pathological process leading to myelofibrosis. In addition, the special features of myelofibrosis in bone marrow diseases, including myeloproliferative neoplasia, myelodysplastic syndrome and other neoplastic conditions are discussed. Orv. Hetil., 2014, 155(10), 367–375.

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