scholarly journals Effects of Oral Amino Acid Supplements on Functional Capacity in Patients with Chronic Heart Failure

2014 ◽  
Vol 8 ◽  
pp. CMC.S14016 ◽  
Author(s):  
Carlo Lombardi ◽  
Valentina Carubelli ◽  
Valentina Lazzarini ◽  
Enrico Vizzardi ◽  
Filippo Quinzani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Functional Capacity ◽  
Exercise Tolerance ◽  
Stress Test ◽  
Nyha Class ◽  
Heart Association

Amino acids (AAs) availability is reduced in patients with heart failure (HF) leading to abnormalities in cardiac and skeletal muscle metabolism, and eventually to a reduction in functional capacity and quality of life. In this study, we investigate the effects of oral supplementation with essential and semi-essential AAs for three months in patients with stable chronic HF. The primary endpoints were the effects of AA's supplementation on exercise tolerance (evaluated by cardiopulmonary stress test and six minutes walking test (6MWT)), whether the secondary endpoints were change in quality of life (evaluated by Minnesota Living with Heart Failure Questionnaire—MLHFQJ and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. We enrolled 13 patients with chronic stable HF on optimal therapy, symptomatic in New York Heart Association (NYHA) class II/III, with an ejection fraction (EF) <45%. The mean age was 59 ± 14 years, and 11 (84.6%) patients were male. After three months, peak VO2 (baseline 14.8 ± 3.9 mL/minute/kg vs follow-up 16.8 ± 5.1 mL/minute/kg; P = 0.008) and VO2 at anaerobic threshold improved significantly (baseline 9.0 ± 3.8 mL/minute/kg vs follow-up 12.4 ± 3.9 mL/minute/kg; P = 0.002), as the 6MWT distance (baseline 439.1 ± 64.3 m vs follow-up 474.2 ± 89.0 m; P = 0.006). However, the quality of life did not change significantly (baseline 21 ± 14 vs follow-up 25 ± 13; P = 0.321). A non-significant trend in the reduction of NT-proBNP levels was observed (baseline 1502 ± 1900 ng/L vs follow-up 1040 ± 1345 ng/L; P = 0.052). AAs treatment resulted safe and was well tolerated by all patients. In our study, AAs supplementation in patients with chronic HF improved exercise tolerance but did not change quality of life.

scholarly journals AEROBIC EXERCISES IN HEART FAILURE - A REVIEW

2012 ◽  
Vol 1 (1) ◽  
pp. 3-8
Author(s):  
Amna Aamir Khan ◽  
Navaid us Saba ◽  
Muhammad Usman Khan
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Aerobic Exercise ◽  
Systematic Reviews ◽  
Nyha Class ◽  
Heart Association ◽  
Aerobic Exercise Training ◽  
Mortality And Morbidity

OBJECTIVE To determine the effect of aerobic exercise training on the quality of life QoL, morbidity, mortality of patients with Heart Failure (HF) EBSCO Host, MedLine, Cochrane database, CINHAL, Ovid, AMED were the databases searched, from 1999 to 2010 which was the peak era of implementation of aerobic exercises for HF and other cardiac diseases. The studies that involved aerobic exercise either in combination or alone were included according to the criteria of New York Heart Association (NYHA) class I-III HF patients. Randomized control trails (RTCs) and systematic reviews were included in the study. The screening of the papers was done by three review authors. The initial screening was conducted by the first author followed by further selection by the second and third. 10 articles met the inclusion criteria including 3 systematic reviews. 3647 participants made one trial greater than the rest. The average age observed was from 30-82 years, where males were dominating in almost all studies. The review reveals no statistical differences in the mortality and morbidity. There was no individual effect of aerobic exercise on QoL whereas better results were reviewed when performed in combination. Aerobic exercises have improved the physiological function, aerobic capacity and quality of life among the patients suffering with HF. However, these exercise therapies were given in combination with resistance training but distinct essence for

Evaluation of the effectiveness of a phase three specialised heart failure cardiac rehabilitation programme on cardiovascular risk factor profile

2021 ◽  
pp. 1-10
Author(s):  
Noeleen Fallon ◽  
Mary Quirke ◽  
Caroline Edgeworth ◽  
Rose O'Mahony ◽  
Nora Flynn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Cardiac Rehabilitation ◽  
Heart Association ◽  
Rehabilitation Programme ◽  
Cardiac Rehabilitation Programme ◽  
Association Class ◽  
New York Heart Association

Background/Aims Cardiac rehabilitation has long been seen as effective for many cardiovascular diseases and, more recently, as having a positive impact on patients with heart failure. To evaluative the effectiveness of a phase three specialised heart failure cardiac rehabilitation programme on patients' cardiovascular risk factor profile. Methods This retrospective, longitudinal study examined profile factors of patients, pre- and post-cardiac rehabilitation programme. Patients with New York Heart Association class I–III, of any origin, were recruited through a specialised heart failure service to a 10-week exercise and education programme. Outcome variables included anxiety, depression, quality of life (Minnesota), 6-minute walking test result, blood pressure, weight, waist circumference, body mass index, Duke Activity Status Index and self-care, and were analysed with the Statistical Package for the Social Sciences using repeated measures t-test. Results 100 patients were eligible and 85 patients completed the programmes. Mean age was 66 years, 80% male, 59% were New York Heart Association class I and 73% had ejection fraction of ≤40%. There was a significant improvement in 6-minute walking test, systolic blood pressure, quality of life and anxiety post programme. Conclusions In-hospital and out of hospital cardiac care has developed significantly, especially in acute symptom control. More recently, emphasis has been put on the long-term control of other risk factors. This study contributes to the literature indicating that attendance at a hospital-based phase three cardiac rehabilitation programme providing supervised, tailored exercise, with intensive education and psychological support, is effective in reducing risk factors and improving quality of life in patients with lower grades of heart failure.

Factors associated with health-related quality of life in stable ambulatory congestive heart failure patients: Systematic review

2018 ◽  
Vol 25 (5) ◽  
pp. 472-481 ◽  
Author(s):  
Anneleen Baert ◽  
Delphine De Smedt ◽  
Johan De Sutter ◽  
Dirk De Bacquer ◽  
Paolo Emilio Puddu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Congestive Heart Failure ◽  
Heart Association ◽  
Functional Class ◽  
Factors Associated ◽  
Related Quality ◽  
New York Heart Association

Background Since improved treatment of congestive heart failure has resulted in decreased mortality and hospitalisation rates, increasing self-perceived health-related quality of life (HRQoL) has become a major goal of congestive heart failure treatment. However, an overview on predictieve factors of HRQoL is currently lacking in literature. Purpose The aim of this study was to identify key factors associated with HRQoL in stable ambulatory patients with congestive heart failure. Methods A systematic review was performed. MEDLINE, Web of Science and Embase were searched for the following combination of terms: heart failure, quality of life, health perception or functional status between the period 2000 and February 2017. Literature screening was done by two independent reviewers. Results Thirty-five studies out of 8374 titles were included for quality appraisal, of which 29 were selected for further data extraction. Four distinct categories grouping different types of variables were identified: socio-demographic characteristics, clinical characteristics, health and health behaviour, and care provider characteristics. Within the above-mentioned categories the presence of depressive symptoms was most consistently related to a worse HRQoL, followed by a higher New York Heart Association functional class, younger age and female gender. Conclusion Through a systematic literature search, factors associated with HRQoL among congestive heart failure patients were investigated. Age, gender, New York Heart Association functional class and depressive symptoms are the most consistent variables explaining the variance in HRQoL in patients with congestive heart failure. These findings are partly in line with previous research on predictors for hard endpoints in patients with congestive heart failure.

scholarly journals Factors Associated With the Level of Movement-Related Everyday Activity and Quality of Life in People With Chronic Heart Failure

2005 ◽  
Vol 85 (12) ◽  
pp. 1340-1348 ◽  
Author(s):  
Rita J van den Berg-Emons ◽  
Johannes B Bussmann ◽  
Aggie H Balk ◽  
Henk J Stam
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Chronic Heart Failure ◽  
Heart Association ◽  
Physiological Factors ◽  
Everyday Activity ◽  
Factors Associated ◽  
Rehabilitation Programs

Abstract Background and Purpose. Cardiac rehabilitation has been shown to be effective in people with chronic heart failure (CHF), particularly in terms of exercise capacity. However, no effects have been found onthe level of movement-related everyday activity. Therefore, rehabilitation programs also should focus on enhancing the level of movement-related everyday activity. The aim of this study was to explore factors associated with the level of movement-related everyday activity and with quality of life in people with CHF. Subjects and Methods. Measurements of movement-related everyday activity (using an accelerometry-based Activity Monitor), quality of life, and associated factors were performed in 36 people with stable CHF (New York Heart Association classes II and III). Results. Knee flexion and extension torque, and particularly extension torque, were significantlyassociated with movement-related everyday activity (r =.43–.49, P&lt;.05), whereas non-physiological factors such as feelings of being disabled were associated with quality of life (r =.37–.77, P≤.01, P&lt;.05). No relationship was found between movement-related everyday activity and quality of life (r =.20–.22, P&gt;.05). Discussion and Conclusion. The results indicate that knee torque is associated with the level of movement-related everyday activity in people with CHF and that quality of life is mediated by nonphysiologicalfactors.

scholarly journals Health-Related Quality of Life and Associated Factors Among Adult Patients With Heart Failure in Tertiary Hospitals, Tigray Region, Northern Ethiopia, 2020.

2021 ◽  
Author(s):  
Abrhaley Belay Shibeshy ◽  
Weyzer Tilahun ◽  
Hagos Tsegabirhan ◽  
Mebrahtom Haftu ◽  
Kiros Belay
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Formal Education ◽  
Heart Association ◽  
Poor Health ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Background Heart failure is a major public health issue for many countries in Sub-Saharan African which causes enormous public health relevance resulting in significant disability, loss of economic productivity, and poor health-related quality of life. Although there is a dated improvement in heart failure management, the morbidity and mortality remain unacceptably high, and a lot of patients are affected by debilitating symptoms which adversely influence their quality of life. Therefore, the main aim of this study was to assess health-related quality of life and associated factors among adult patients with heart failure in tertiary hospitals, Tigray region, Ethiopia, 2020.Methods An institutional-based cross-sectional study was conducted from March 01-April 30, 2020. A simple random sampling method was used to enroll the 301 participants. Data were collected using a structured questionnaire-based interview. The health-related quality of life measuring tool was adapted from the medical outcomes study. Data was entered to and cleaned by Epi-Data manager version 4.4.2.1 and exported to a statistical package of social science version 22 for analysis. Binary logistic regression model (Adjusted Odds ratio, 95% Confidence Interval, and P-value < 0.05) was used to determine the factors that influence health-related quality of life.Results This study showed that 142(47.2%) patients had a poor health-related quality of life. The overall mean score of health-related quality of life was 61.7±20.5 among patients. Age above 60 years (AOR; 4.47, 95% CI; 1.87-10.68), no formal education (AOR; 3.45, 95% CI; 1.31-9.12), New-York Heart Association class-ɪᴠ (AOR; 6.50, 95% CI; 2.62-16.13) and the absence of social support (AOR; 2.52, 95% CI; 1.33-4.79) were significantly associated with poor health‐related quality of life.ConclusionsHealth-related quality of life among heart failure patients was poor for almost half of the participants. Patients with older age, no formal education, and higher New York Heart Association class need special attention in each follow-up evaluation. Furthermore, health professionals and governments should inform the benefit of social support to family members and friends who are involved in the care process among heart failure patients.

Giving intravenous iron to patients with symptomatic heart failure is safe and cost effective

2021 ◽  
pp. 1-5
Author(s):  
James Redfern ◽  
Rachel Goode ◽  
Wing Yin Leung ◽  
Clare Quarterman ◽  
Archana Rao
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
New York ◽  
Heart Association ◽  
Intravenous Iron ◽  
Cost Effective ◽  
Ferric Carboxymaltose ◽  
Association Class ◽  
New York Heart Association

Aims/Background Heart failure affects approximately 1 million people in the UK, adversely affecting quality of life, functional capacity and cognitive health. Iron deficiency complicates heart failure in approximately 50% of patients. Giving intravenous ferric carboxymaltose has been shown to improve quality of life in patients with heart failure (New York Heart Association class and Kansas City Cardiomyopathy Questionnaire). Methods A quality improvement project was designed to assess the feasibility, safety and cost implications of establishing an intravenous iron service in the authors' centre. Results Between July and December 2019 61 patients who were screened met the inclusion criteria and were administered intravenous ferric carboxymaltose. There were statistically significant improvements in ferritin levels (83.3 ug/litre to 433 ug/litre; P<0.0001), transferrin saturation (18% to 30% P<0.0001) and haemoglobin levels (126 g/litre to 135 g/litre; P<0.01). No demonstrable changes in New York Heart Association class or quality of life scores were noted. The overall financial impact for the trust was income generation of £14 665, a net income of £240 per patient. Conclusions Intravenous iron replacement with ferric carboxymaltose is safe and cost effective, and should be considered in eligible iron-deficient patients with symptomatic heart failure. Integration with another day case intravenous service represented the most logistically simple and economically viable method of service delivery.

P769Quality of life in outpatients with heart failure in relation to mortality and admissions for heart failure

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Grundtvig ◽  
T Vollnes-Eriksen ◽  
T Hole
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Nyha Class ◽  
Functional Class ◽  
Physical Domain ◽  
Significant Independent Predictor ◽  
Nyha Functional Class ◽  
Daily Dose

Abstract Studies report relation between quality of life and outcome. However, less is known about how various aspects of quality of life relates to mortality and admissions for heart failure. Method Mortality was examined in 7001 patients with completed Minnesota Living with Heart Failure Questionnaire (MLWHFQ) at the first visit to specialised hospital outpatient clinics included in our registry. A subset of 4264 patients with a second MLWHFQ at a late follow-up visit was assessed for the number of admissions and days in hospital for reason of heart failure during a six months period prior to the late visit. Results In multivariate Cox proportional hazard regression model for time to death after the first visit with a median 19 months follow-up and 1001 deaths, the MLWHFQ score for the subset of the “physical domain” (question 2 to 9) was a significant independent predictor for mortality (P=0.002) adjusted for gender, NYHA-class, blood pressure, s-sodium, stroke, obstructive lung disease, eGFR, anemia, age, daily dose diuretic, and ischemic cause for heart failure. The total MLWHFQ score and the Minnesota “emotional domain” (question 17–21) were not significant variables when the MLWHFQ “physical domain” was entered in the analysis. The number of admissions for heart failure and the number of days in hospital for these admissions in a six months period prior to the late visit were analysed by linear regression for related variables. The total MLWHFQ score at the late visit was highly significant for the number of admissions in the six months period (p<0.001) adjusted for the daily dose diuretic, NYHA functional class and proBNP. The MLWHFQ “physical domain” and the MLWHFQ “emotional domain” were not significant variables when the total score was entered. The number of days in hospital was related to the daily dose diuretic, NYHA functional class, proBNP, and in addition anaemia at the late visit again with the MLWHFQ total score being a significant predictor (=0.001) Conclusions Disease specific quality of life measured with MLWHFQ “physical domain” was a highly significant predictor for mortality after the first visit. The late total MLWHFQ score was a better predictor for heart failure related admissions and days in hospital than the subset domains in multivariate analysis. Acknowledgement/Funding None

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