Olmesartan-Amlodipine-Hydrochlorothiazide in Fixed Combination for the Treatment of Hypertension

2012 ◽  
Vol 4 ◽  
pp. 1-8
Keyword(s):  
Fixed Combination ◽  
Treatment Of Hypertension

scholarly journals Pharmacoepidemiological study of recommendations of diuretics for the treatment of hypertension in the outpatient setting

2014 ◽  
Vol 11 (3) ◽  
pp. 48-52
Author(s):  
A I Ponomareva ◽  
O G Kompaniets ◽  
R M Linchak ◽  
M M Nemirovskaya ◽  
M V Strokan ◽  
...  
Keyword(s):  
Sampling Method ◽  
Fixed Combination ◽  
Diuretic Therapy ◽  
Real Life ◽  
Outpatient Setting ◽  
Regional Study ◽  
Hypertensive Disease ◽  
Pharmacoepidemiological Study ◽  
Angiotensin System ◽  
Treatment Of Hypertension

The aim of the study is pharmacoepidemiologicalanalysis of the structureandreasonability of diuretic therapy in patients with hypertensive disease (HD)in ‘real-life’ clinical practicesettings.Materialandmethods:we underwentthe retrospectivepharmacoepidemiologicalcomparative analysisof the structureofdiuretic therapyreviewingoutpatient cardsfrom 2011 to 2014.We extracted data from outpatientcardsin outpatient department of Krasnodar Territoryusingcontinuous sampling method(421 patients)with the subsequent assessmentin accordance withmodern guidance materials. Results. In comparison with the regional study historic resultsthe administrationoftorsemidehad significantly increasedin patients withHD andnoncomplicatedchronic cardiac failure(12%).The priority drugs for the administrationamong diuretics werehydrochlorothiazide (24%)and indapamide (20%),spironolactone (20%).The ACE inhibitoror sartanusing in fixed combination with diuretic was recommended in 20% of out- patient cards.Structure ofdiuretic distribution in group of patients with HD, associated withCHF(II-IVfunctional class)had showedthe efficiencyof spironolactonein26%,of hydrochlorothiazide - 15%,torsemide - 13%,indapamide - 7%;the combination of spironolactoneandtorsemidewas receivedby 14% of patients,the combination of spironolactoneandhydrochlorothiazide - 6%,spironolactoneand furosemide - 1%,in 4% of outpatient cardswe noticed the triple combination of monocomponentdiuretic.Conclusion. We did not find unreasonable administration of diuretic therapy combination out ofindication and in the presence of contradictions.The prescription of modern long-termdiuretics associated with lower risk of side-effects developing will improve efficiencyand safetyof pharmacotherapy.It is very important to use fixed drugs combinationin case of administration the diuretic and agentsofrenin angiotensin system inhibitors.The volume and prescription reasonability analysis ofdiuretic therapy in patients withHDin ‘real-life’ clinical practicesettingshas shown compliance with modernnational guidance materials for the HD and CHF treatment.

scholarly journals Fixed combination of lercanidipine with enalapril - pharmacological features, clinical feasibility, advantages in the treatment of hypertension

2021 ◽  
pp. 21-24
Author(s):  
P. О. Lazarev
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Arterial Hypertension ◽  
Fixed Combination ◽  
Antihypertensive Drugs ◽  
Mechanisms Of Action ◽  
High Efficacy ◽  
National Guidelines ◽  
Treatment Of Hypertension ◽  
And Oxidative Stress

According to current international and national guidelines for the management of arterial hypertension preference is given to the use of fixed combinations of antihypertensive drugs of different classes, thus increasing the effectiveness of therapy acting in a complementary manner to affect different pathogenic mechanisms of arterial hypertension and reducing the frequency of side effects. A fixed combination of lercanidipine and enalapril contains antihypertensive drugs that have complementary mechanisms of action. This combination effectively reduces blood pressure, has high efficacy and tolerability, it may provide an additive effect on macro- and microvascular structures, arterial stiffness and oxidative stress. It has a beneficial influence on renal function, especially in patients with comorbidities.

scholarly journals Fixed combinations in modern hypertension treatment algorithms

2018 ◽  
Vol 17 (6) ◽  
pp. 86-94
Author(s):  
E. V. Sayutina
Keyword(s):  
Fixed Combination ◽  
Antihypertensive Efficacy ◽  
Protective Effects ◽  
Hypertension Treatment ◽  
First Line ◽  
Treatment Algorithms ◽  
Appropriate Treatment ◽  
Treatment Of Hypertension ◽  
European Society Of Cardiology ◽  
Prior Stroke

Modern appropriate treatment of hypertension involves the use of combination antihypertensive therapy. According to updated version of European Society of Cardiology 2018 guidelines, renin-angiotensin-aldosterone system blockers must be used as first-line drugs, including in combination with hydrochlorothiazide. This article presents the algorithms for the management of patients with uncomplicated and asymptomatic (with target lesions) arterial hypertension. It also described the management of patients with concomitant cardiovascular, cerebrovascular, renal pathology and diabetes mellitus, and use of fixed combination of candesartan and hydrochlorothiazide. The article presents research data that confirmed not only the high antihypertensive efficacy of this combination, but also demonstrated its neutral metabolic profile, organ-protective effects, the ability to use in patients with chronic kidney disease, chronic heart failure, prior stroke, as well as high tolerability and treatment adherence.

scholarly journals Sympathometabolic profile of a fixed combination of lercanidipine with enalapril in the treatment of obese hypertensive patients (study review)

2021 ◽  
pp. 36-37
Author(s):  
P. A. Lazarev
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Calcium Channel Blockers ◽  
Enzyme Inhibitors ◽  
Fixed Combination ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Channel Blockers ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Hypertensive Patients ◽  
Treatment Of Hypertension

The publication highlights the main possibilities of fixed combinations of angiotensin-converting enzyme inhibitors with calcium channel blockers in the treatment of hypertension and the advantages of the combination of enalapril 20 mg / lercanidipine 10 mg in terms of sympathomodulatory properties. Clinical data are provided that indicate the benefit of using this combination in patients with hypertension and concomitant obesity

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