A Review of Topical Povidone-iodine to Decrease Viral Load of COViD-19

2021 ◽  
Vol 36 (5) ◽  
pp. 238-241
Author(s):  
Katherine M. Benson ◽  
Amalia A. Mancini ◽  
Michael R. Brodeur
Keyword(s):  
Viral Load ◽  
Respiratory Tract Infections ◽  
Povidone Iodine ◽  
Preventive Measure ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Clinical Trial Results ◽  
Tract Infections

Topical povidone-iodine (PVP-I) is currently being considered as a potential preventive measure against the spread of COVID-19. Diluted PVP-I solutions have been historically used in Asia to treat upper respiratory tract infections (URTIs) by decreasing the bacterial and viral load on oropharyngeal mucosa to decrease the transmission of diseases. Efficacy of gargling 0.23% PVP-I mouthwash in Japan demonstrated to be efficacious in lowering the prevalence of URTIs when compared with placebo. The 0.23% concentration was used in vitro on severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, which produced undetectable results after 30 seconds of exposure. Additionally, a recent study in 2020 proved the efficacy of PVP-I 0.45%-10% in reducing COVID-19 (SARS-CoV 2) viral load in vitro. Numerous clinical trials are being conducted to determine if there is a decrease in viral load, and thus transmission, when using oral or nasal topical PVP-I in COVID-19 patients. Because of the current lack of evidence for the use of PVP-I in vivo with COVID-19, it is recommended to await the clinical trial results before initiating this practice.

A Review of Topical Povidone-iodine to Decrease Viral Load of COViD-19

2021 ◽  
Vol 36 (5) ◽  
pp. 238-241
Author(s):  
Katherine M. Benson ◽  
Amalia A. Mancini ◽  
Michael R. Brodeur
Keyword(s):  
Viral Load ◽  
Respiratory Tract Infections ◽  
Povidone Iodine ◽  
Preventive Measure ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Clinical Trial Results ◽  
Tract Infections

Topical povidone-iodine (PVP-I) is currently being considered as a potential preventive measure against the spread of COVID-19. Diluted PVP-I solutions have been historically used in Asia to treat upper respiratory tract infections (URTIs) by decreasing the bacterial and viral load on oropharyngeal mucosa to decrease the transmission of diseases. Efficacy of gargling 0.23% PVP-I mouthwash in Japan demonstrated to be efficacious in lowering the prevalence of URTIs when compared with placebo. The 0.23% concentration was used in vitro on severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, which produced undetectable results after 30 seconds of exposure. Additionally, a recent study in 2020 proved the efficacy of PVP-I 0.45%-10% in reducing COVID-19 (SARS-CoV 2) viral load in vitro. Numerous clinical trials are being conducted to determine if there is a decrease in viral load, and thus transmission, when using oral or nasal topical PVP-I in COVID-19 patients. Because of the current lack of evidence for the use of PVP-I in vivo with COVID-19, it is recommended to await the clinical trial results before initiating this practice.

scholarly journals Toxicity evaluation of an essential oil mixture from the Cretan herbs thyme, Greek sage and Cretan dittany

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Konstantina Kalyvianaki ◽  
Panagiotis Malamos ◽  
Niki Mastrodimou ◽  
Ioanna Manoura-Zonou ◽  
Rodanthi Vamvoukaki ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Respiratory Tract Infections ◽  
Intervention Studies ◽  
Upper Respiratory Tract ◽  
Aromatic Plants ◽  
Toxicity Evaluation ◽  
Upper Respiratory ◽  
Tract Infections

Abstract The importance of herbal extracts on health, which was initially based on ethnopharmacological and traditional knowledge, becomes increasingly well documented by numerous experimental and intervention studies. The daily use of beverages from different aromatic plants which becomes more popular nowadays, has been a tradition in Crete, and a habit that has been linked to the longevity seen in the island. Additionally, a certain combination of aromatic plants has been used against common cold and influenza. Interestingly, when such a mixture of essential oils from Cretan herbs (Cretan Aromatic Plants essential oil, CAPeo, from thyme, Greek sage, and Cretan dittany) was formulated, significant antiviral properties were observed in vitro and a significant reduction in the duration and severity of symptoms of patients with upper respiratory tract infections was found in a clinical study. However, since many plants extracts can exert toxic effects, toxicity issues should be properly addressed. In the present work we present an acute and sub-chronic toxicity evaluation for this mixture of aromatic plants’ essential oils in rats. In fact, it is the only toxicity study for Cretan dittany. We report absence of toxicity, rendering the use of the mixture of essential oils from Cretan dittany, Greek sage and thyme as safe.

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