scholarly journals Association of single nucleotide polymorphisms in FGF-RAS/MAP signalling cascade with breast cancer susceptibility

2017 ◽  
Vol 36 (05) ◽  
pp. 565-572 ◽  
Author(s):  
Zuzana Dankova ◽  
Pavol Zubor ◽  
Marian Grendar ◽  
Andrea Kapinova ◽  
Katarina Zelinova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Signalling Cascade

scholarly journals The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e70656 ◽  
Author(s):  
Ping-Yu Wang ◽  
Zong-Hua Gao ◽  
Zhong-Hua Jiang ◽  
Xin-Xin Li ◽  
Bao-Fa Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jiaping Chen ◽  
Yue Jiang ◽  
Jing Zhou ◽  
Sijun Liu ◽  
Yayun Gu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
In Silico ◽  
Promoter Region ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Close Association ◽  
Breast Cancer Susceptibility ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women. Seven potentially functional SNPs were investigated using genotyping assays. The potential biological functions of the identified positive SNPs were further evaluated using in silico databases. We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35). The other six single nucleotide polymorphisms exhibited negative associations. Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression. These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women.

scholarly journals Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population

Oncotarget ◽  
2016 ◽  
Vol 7 (34) ◽  
pp. 54771-54781 ◽  
Author(s):  
Ming Liu ◽  
Bin Li ◽  
Wen Guo ◽  
Xiyang Zhang ◽  
Zhengshuai Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Han Chinese Population

scholarly journals Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms

2004 ◽  
Vol 10 (8) ◽  
pp. 2725-2737 ◽  
Author(s):  
Jennifer Listgarten ◽  
Sambasivarao Damaraju ◽  
Brett Poulin ◽  
Lillian Cook ◽  
Jennifer Dufour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Predictive Models ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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