Magnetic solid-phase extraction coupled with UHPLC–MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples

Aim: Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug–drug interactions or overlapping toxicity. Materials & methods: A magnetic solid-phase extraction by using C18-functionalized magnetic silica nanoparticles (C18-Fe3O4@SiO2 NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC–MS/MS assay. Results: The synthesized C18-Fe3O4@SiO2 NPs showed high magnetization and efficient extraction for the analytes. After cleanup by magnetic solid-phase extraction, no matrix effects were found in plasma and urine matrices. The analytes showed LODs among 0.15–0.75 ng ml-1, appropriate linearity (R ≥ 0.9990) from 2.5 to 1000 ng ml-1, acceptable accuracies 89.1–110.9% with precisions ≤11.0%. The protocol was successfully applied for the analysis of patients’ plasma and urine samples. Conclusion: It shows high potential in routine therapeutic drug monitoring of clinical biological samples.

Download Full-text

Magnetic Solid-Phase Extraction Using Fe3O4@SiO2 Magnetic Nanoparticles Followed by UV-Vis Spectrometry for Determination of Paraquat in Plasma and Urine Samples

Journal of Analytical Methods in Chemistry ◽

10.1155/2017/8704639 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Ou Sha ◽

Yu Wang ◽

Xin Yin ◽

Xiaobing Chen ◽

Li Chen ◽

...

Keyword(s):

Solid Phase Extraction ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Phase Extraction ◽

Simple Method ◽

Relative Standard ◽

Plasma And Urine Samples ◽

Magnetic Solid

A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold. The linear range, limit of detection (LOD), correlation coefficient (R), and relative standard deviation (RSD) could reach 15.0–400.0 μg/L, 12.2 μg/L, 0.9987, and 0.65% (n=5, c = 40.0 μg/L), respectively. The Fe3O4@SiO2 NPs could be reused up to five times. The method was successfully applied to the determination of paraquat in urine and plasma at different hemoperfusion numbers in a local hospital for the patient of paraquat poisoning. The experiment result could not only enable immediate medical intervention but also benefit patients’ survival.

Download Full-text

Glutathione‐stabilized Fe 3 O 4 nanoparticles as the sorbent for magnetic solid‐phase extraction of diazepam and sertraline from urine samples through quantitation via high‐performance liquid chromatography

Journal of Separation Science ◽

10.1002/jssc.202000938 ◽

2020 ◽

Author(s):

Milad Ghani ◽

Zahra Zayeri ◽

Behrooz Maleki

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Solid Phase Extraction ◽

High Performance ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Phase Extraction ◽

Magnetic Solid

Download Full-text

Magnetic solid-phase extraction using poly(para-phenylenediamine) modified with magnetic nanoparticles as adsorbent for analysis of monocyclic aromatic amines in water and urine samples

Journal of Chromatography A ◽

10.1016/j.chroma.2015.08.046 ◽

2015 ◽

Vol 1415 ◽

pp. 20-26 ◽

Cited By ~ 31

Author(s):

Amirhassan Amiri ◽

Mehdi Baghayeri ◽

Somayeh Nori

Keyword(s):

Magnetic Nanoparticles ◽

Solid Phase Extraction ◽

Aromatic Amines ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Phase Extraction ◽

Magnetic Solid

Download Full-text

Rapid and simple magnetic solid-phase extraction of bisphenol A from bottled water, baby bottle, and urine samples using green magnetic hydroxyapatite/β-cyclodextrin polymer nanocomposite

Microchemical Journal ◽

10.1016/j.microc.2022.107180 ◽

2022 ◽

pp. 107180

Author(s):

Mohammad Reza Bayatloo ◽

Saeed Nojavan

Keyword(s):

Bisphenol A ◽

Solid Phase Extraction ◽

Solid Phase ◽

Polymer Nanocomposite ◽

Magnetic Solid Phase Extraction ◽

Bottled Water ◽

Urine Samples ◽

Phase Extraction ◽

Baby Bottle ◽

Magnetic Solid

Download Full-text

Magnetic Solid-Phase Extraction Based on Poly 4-Vinyl Pyridine for HPLC-FLD Analysis of Naproxen in Urine Samples

Molecules ◽

10.3390/molecules25122924 ◽

2020 ◽

Vol 25 (12) ◽

pp. 2924

Author(s):

Karen A. Escamilla-Lara ◽

Ana C. Heredia ◽

Araceli Peña-Alvarez ◽

Israel S. Ibarra ◽

Enrique Barrado ◽

...

Keyword(s):

Solid Phase Extraction ◽

Limit Of Detection ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Phase Extraction ◽

Optimal Conditions ◽

Fluorescence Detector ◽

Vinyl Pyridine ◽

Magnetic Solid

A magnetic solid phase extraction technique followed by liquid chromatography with a fluorescence detector for naproxen analysis in human urine samples was developed. The method includes the extraction of naproxen with a magnetic solid synthetized with magnetite and poly 4-vinylpriridine, followed by the magnetic separation of the solid phase and desorption of the analyte with methanol. Under optimal conditions, the linear range of the calibration curve was 0.05–0.60 μg L−1, with a limit of detection of 0.02 μg L−1. In all cases values of repeatability were lower than 5.0% with recoveries of 99.4 ± 1.3%. Precision and accuracy values are adequate for naproxen (Npx) analysis in urine samples.

Download Full-text

Carbon coated magnetic nanoparticles as a novel magnetic solid phase extraction adsorbent for simultaneous extraction of methamphetamine and ephedrine from urine samples

Journal of Chromatography B ◽

10.1016/j.jchromb.2016.11.039 ◽

2017 ◽

Vol 1041-1042 ◽

pp. 113-119 ◽

Cited By ~ 24

Author(s):

Arezou Taghvimi ◽

Hamed Hamishehkar

Keyword(s):

Magnetic Nanoparticles ◽

Solid Phase Extraction ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Phase Extraction ◽

Simultaneous Extraction ◽

Carbon Coated ◽

Magnetic Solid

Download Full-text

A powerful combination of quadruple isotope dilution strategy with dispersive magnetic solid phase extraction for the accurate and precise multi-analyte determination of tadalafil, sildenafil, avanafil and vardenafil in human plasma and urine samples using LC-ESI-Tandem MS

Microchemical Journal ◽

10.1016/j.microc.2019.104302 ◽

2020 ◽

Vol 152 ◽

pp. 104302 ◽

Cited By ~ 1

Author(s):

Elif Öztürk Er ◽

Erhan Akkaya ◽

Belma Özbek ◽

Sezgin Bakırdere

Keyword(s):

Solid Phase Extraction ◽

Human Plasma ◽

Isotope Dilution ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Tandem Ms ◽

Phase Extraction ◽

Plasma And Urine Samples ◽

Magnetic Solid

Download Full-text

Determination of losartan potassium in the presence of hydrochlorothiazide via a combination of magnetic solid phase extraction and fluorometry techniques in urine samples

RSC Advances ◽

10.1039/c5ra20117a ◽

2015 ◽

Vol 5 (124) ◽

pp. 102895-102903 ◽

Cited By ~ 17

Author(s):

Amir Farnoudian-Habibi ◽

Sahar Kangari ◽

Bakhshali Massoumi ◽

Mehdi Jaymand

Keyword(s):

Solid Phase Extraction ◽

Efficient Method ◽

Solid Phase ◽

Magnetic Solid Phase Extraction ◽

Urine Samples ◽

Losartan Potassium ◽

Phase Extraction ◽

Highly Efficient ◽

Magnetic Solid

A sensitive and highly efficient method for the determination of losartan potassium (LOS) in the presence of hydrochlorothiazide (HCTZ) via a combination of magnetic solid phase extraction (MSPE) and fluorometry techniques is suggested.

Download Full-text