Validation of LC–MS/MS bioanalytical methods for protein therapeutics

Bioanalysis ◽  
2014 ◽  
Vol 6 (13) ◽  
pp. 1739-1742 ◽  
Author(s):  
Faye Vazvaei ◽  
Jeffrey X Duggan
Keyword(s):  
Bioanalytical Methods ◽  
Protein Therapeutics

Creatinine Deiminase: Characterization, Using in Enzymatic Creatinine Assay, and Production of the Enzyme

2019 ◽  
Vol 20 (5) ◽  
pp. 465-470 ◽  
Author(s):  
Andriy Zakalskiy ◽  
Nataliya Stasyuk ◽  
Mykhailo Gonchar
Keyword(s):  
Quantitative Determination ◽  
Sport Medicine ◽  
Bioanalytical Methods ◽  
Physiological Status ◽  
Recombinant Strains

The goal of the review is description of the main characteristics of creatinine deiminase (CDI), an important bioanalytical tool for creatinine (Crn) assay. Crn is an essential metabolite for diagnostics of kidney disfunction and some other diseases, a biomarker to control the hemodialysis procedure, as well as an important analyte for sport medicine (estimation of general physiological status of athletes). We have described the important sources for CDI isolation, cloning of the corresponding gene, the construction of microbial recombinant strains, overproducing CDI, and characteristics of the enzyme from different microorganisms. There are reviewing also the new bioanalytical methods for quantitative determination of Crn, including enzymatic ones based on using CDI.

Bioanalytical methods for circulating extracellular matrix-related proteins: new opportunities in cancer diagnosis

2021 ◽  
Author(s):  
Ramón Lorenzo-Gómez ◽  
Rebeca Miranda-Castro ◽  
Noemí de-los-Santos-Álvarez ◽  
María Jesús Lobo-Castañón
Keyword(s):  
Extracellular Matrix ◽  
Cancer Diagnosis ◽  
Bioanalytical Methods ◽  
Related Proteins

Pharmacogenetics and the Immunogenicity of Protein Therapeutics

2014 ◽  
Vol 34 (12) ◽  
pp. 931-937 ◽  
Author(s):  
Gouri S. Pandey ◽  
Zuben E. Sauna
Keyword(s):  
Protein Therapeutics

scholarly journals CMC and regulatory considerations for polyethylene glycol-modified protein therapeutics

2005 ◽  
Vol 20 (6) ◽  
pp. 620-634 ◽  
Author(s):  
Susan Cannon-Carlson ◽  
David Wylie ◽  
Doug Kline ◽  
Doug Inloes
Keyword(s):  
Polyethylene Glycol ◽  
Protein Therapeutics

Pharmacokinetics and protein therapeutics

1990 ◽  
Vol 4 (3) ◽  
pp. 359-386 ◽  
Author(s):  
Carol A. Gloff ◽  
Leslie Z. Benet
Keyword(s):  
Protein Therapeutics

In vitro tools for the toxicological evaluation of sediments and dredged materials: intra- and inter-laboratory comparisons of chemical and bioanalytical methods

2017 ◽  
Vol 25 (5) ◽  
pp. 4037-4050 ◽  
Author(s):  
Kathrin Eichbaum ◽  
Markus Brinkmann ◽  
Leonie Nuesser ◽  
Carolin Gembé ◽  
Marina Ohlig ◽  
...  
Keyword(s):  
Bioanalytical Methods ◽  
Toxicological Evaluation ◽  
Dredged Materials
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