Leveraging conformational control about a potential atropisomeric axis as a strategy in medical chemistry

2021 ◽  
Vol 13 (5) ◽  
pp. 443-446
Author(s):  
Sean T Toenjes ◽  
Mariam Basilaia ◽  
Jeffrey L Gustafson
Keyword(s):  
Conformational Control ◽  
Medical Chemistry

scholarly journals Front Cover: Two‐step Conformational Control of a Dibenzo Diazacyclooctane Derivative by Stepwise Protonation (Asian J. Org. Chem. 6/2021)

2021 ◽  
Vol 10 (6) ◽  
pp. 1216-1216
Author(s):  
Fumitaka Ishiwari ◽  
Sayuri Miyake ◽  
Keiki Inoue ◽  
Keiji Hirose ◽  
Takanori Fukushima ◽  
...  
Keyword(s):  
Conformational Control ◽  
Front Cover

scholarly journals Construction of a cross-layer linked G-octamer via conformational control: a stable G-quadruplex in H-bond competitive solvents

2019 ◽  
Vol 10 (15) ◽  
pp. 4192-4199 ◽  
Author(s):  
Ying He ◽  
Yanbin Zhang ◽  
Lukasz Wojtas ◽  
Novruz G. Akhmedov ◽  
David Thai ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Cross Layer ◽  
Conformational Control ◽  
G Quadruplex ◽  
Improved Stability ◽  
First Time

A discrete and well-defined G-octamer system has been established through conformational design of monomers. The crystal structures of G-octamers were obtained for the first time. The covalent linked G-quadruplex exhibited significantly improved stability in both methanol and DMSO.

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