IS SEX A PREDICTOR OF OUTCOME OF ANTITHYROID THERAPY OF GRAVES HYPERTHYROIDISM?

ABSTRACT Introduction: Pacients with Down’s syndrome present an increase revalence of autoimune endocrine disorders. We communicate the case of 14 years and 6 months old pacient known with Down syndrome admitted in Endocrinology department with suspicion of hyperthyroidism, the diagnosis being confirmed by hormonal dosage. The particularity of the case consists in: symptomatology onset during puberty, clinical evolution with mild symptoms, without ocular involvement, morphological and functional remission obtained relatively soon after the initiation of antithyroid therapy, lack of posttherapy side effects, favorabile evolution under the “block and replace” therapy

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Hyperthyroidism in a 3-month-old Baby

PEDIATRICS ◽

10.1542/peds.47.6.1069 ◽

1971 ◽

Vol 47 (6) ◽

pp. 1069-1073

Author(s):

Hannah E. Leszynsky ◽

Eva Gross-Kieselstein ◽

Abraham Abrahamov

Keyword(s):

Male Infant ◽

Cardiac Insufficiency ◽

Thyroid Cell ◽

Antithyroid Therapy ◽

Antecedent Infection ◽

Long Acting

A case of acute and severe thyrotoxicosis (without goiter and exophthalmos) in a 3-month-old male infant is reported. The case is unusual because of (1) the extreme rarity of the condition below the age of 6 months, and (2) the presence of features characteristic of the neonatal variety (gross cardiac insufficiency, hepatoslpenomegaly out of proportion to the heart.) LATS (long-acting thyroid stimulator) assay was positive in the patient and negative in his mother who was euthyroid. Prolonged antithyroid therapy was required to maintain the remission induced by iodine. It is postulated that in the present case an antecedent infection acting upon a (hereditarily transmitted?) liability of the thyroid cell toward disordered function, was the direct cause.

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Migratory polyarthritis as an adverse effect of thiamazole use in a 13-year-old girl with Graves’ disease

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2014-0433 ◽

2015 ◽

Vol 28 (9-10) ◽

Cited By ~ 1

Author(s):

Jo-Anne Janson ◽

Paul de Laat ◽

Jos M.T. Draaisma

Keyword(s):

Adverse Effect ◽

Radioactive Iodine ◽

Treatment Modalities ◽

Definitive Treatment ◽

Severe Adverse Effect ◽

Graves Disease ◽

Antithyroid Therapy ◽

Migratory Polyarthritis

AbstractGraves’ disease is the most prevalent cause of hyperthyroidism in children. The treatment commonly involves antithyroid therapy using a thionamide. We present a case of a 13-year-old girl with the antithyroid arthritis syndrome, presenting as a migratory polyarthritis, after the initiation of thionamide treatment for Graves’ disease. Antithyroid arthritis syndrome warranted immediate cessation of thionamide. Improvement of the arthritis was seen in subsequent days. As there are no other reversible treatment modalities for Graves’ disease in children, definitive treatment with radioactive iodine was needed to control the hyperthyroidism in this child. Antithyroid arthritis syndrome presenting as a migratory polyarthritis is a severe adverse effect of a common pediatric disease and should therefore be recognized by pediatricians.

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