Preparation of Spherically Granulated Crystals of Waxy Drug(Tocopherol Nicotinate) for Direct Tableting by Spherical Crystallization Technique.

In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is important for obtaining the ideal spherical crystal agglomerates. It includes stirring rate, selection of solvent, pH, temperature etc. which affects on the physico-chemical properties of crystals. These optimizing parameters play its specific role in formation of spherical crystals. Stirring rate affects the shape as well as size of the final agglomerates and solvent selection helps in the formation of maximum amount of agglomerates in the system. The factors like pH and temperature should be maintained in case of drugs which show polymorphism. Apart from this, several others physical phenomenon or parameters like interfacial tension and rate of crystallisation are also important for thorough optimization of process.

Download Full-text

Design of Spherical Crystallization of Active Pharmaceutical Ingredients via a Highly Efficient Strategy: From Screening to Preparation

ACS Sustainable Chemistry & Engineering ◽

10.1021/acssuschemeng.1c01973 ◽

2021 ◽

Author(s):

Yiming Ma ◽

Mengmeng Sun ◽

Yanbo Liu ◽

Mingyang Chen ◽

Songgu Wu ◽

...

Keyword(s):

Active Pharmaceutical Ingredients ◽

Efficient Strategy ◽

Pharmaceutical Ingredients ◽

Highly Efficient ◽

Spherical Crystallization

Download Full-text

Process Intensification through Continuous Spherical Crystallization Using an Oscillatory Flow Baffled Crystallizer

Crystal Growth & Design ◽

10.1021/acs.cgd.7b00731 ◽

2017 ◽

Vol 17 (9) ◽

pp. 4776-4784 ◽

Cited By ~ 17

Author(s):

Ramon Peña ◽

Joseph A. Oliva ◽

Christopher L. Burcham ◽

Daniel J. Jarmer ◽

Zoltan K. Nagy

Keyword(s):

Oscillatory Flow ◽

Process Intensification ◽

Spherical Crystallization

Download Full-text

Spray-dried composite particles of erythritol and porous silica for orally disintegrating tablets prepared by direct tableting

Powder Technology ◽

10.1016/j.powtec.2015.08.011 ◽

2015 ◽

Vol 286 ◽

pp. 444-450 ◽

Cited By ~ 10

Author(s):

Shinji Tanimura ◽

Kohei Tahara ◽

Hirofumi Takeuchi

Keyword(s):

Porous Silica ◽

Composite Particles ◽

Orally Disintegrating Tablets ◽

Direct Tableting ◽

Spray Dried

Download Full-text

Pharmaceutical and Macromolecular Technologies in the Spirit of Industry 4.0

Periodica Polytechnica Chemical Engineering ◽

10.3311/ppch.12870 ◽

2018 ◽

Vol 62 (4) ◽

Cited By ~ 2

Author(s):

György Marosi ◽

Edit Hirsch ◽

Katalin Bocz ◽

Andrea Toldy ◽

Beáta Szolnoki ◽

...

Keyword(s):

Flame Retardant ◽

Significant Role ◽

Flame Retardancy ◽

Industry 4.0 ◽

Reinforced Composites ◽

Electric Cars ◽

Direct Tableting

Well designed (multilayer, adaptive, reactive) interphases, being a key element of multicomponent structures, could be tailored to different requirements through controlled technologies. This is the link connecting various green, safe, healthy materials and innovative pharmaceuticals. Upgraded recycling could be performed by interfacial consolidation of self-reinforced composites, the flame retardancy of which is feasible with surprisingly low amount of flame retardant. Examples are shown how the reinforced and foamed forms of thermosetting and thermoplastic biopolymers can play a significant role (after flame retardant modification) in the development of airplanes and electric cars. Biopolymer nanofibres, such as polycaprolactone and polyhydroxybutyrate, could be formed with increased productivity for various medical uses. Raman-based control of the units of integrated continuous technologies has been elaborated including controlled formation of crystals with polymer interlayer for direct tableting.

Download Full-text