Solubility Enhancement of Antihyperlipidemic Drug by Solvent Diffusion Technique

Poor aqueous solubility of drugs is major limiting factor with many new drugs in their successful launch in market in spite of their potential pharmacokinetic activity. Therefore, poor solubility is critical factor if the molecule is to survive the pharmaceutical development process. In the current work, it was planned to enhance the solubility of antihyperlipidemic drug by solvent diffusion technique. For this the drug clofibrate and excipients were procured and spherical agglomerates were prepared and evaluated. The findings of the study states the novelty the hypothesis. Keywords: Solubility, Diffusion, Agglomerates

Manufacturing Elements with Small Cross-Sections of 17-4 PH Steel (1.4542) with the Application of the DMLS Additive Manufacturing Method

The application of direct metal laser sintering renders it possible to manufacture models with complex geometries. However, there are certain limits to the application of this method connected with manufacturing thin-walled cuboidal elements, as well as cylinders and holes with small diameters. The principal objective of the research was to determine the accuracy of manufacturing geometries with small cross-sections and the possibility of application in heat exchangers that are radiators with radially arranged ribs. To that end, four specimens were designed and manufactured; their geometries of representations assumed for the purpose of research (analysis) changed dimensions within the following scope: 10–0.1 mm. The specimens to be applied in the research were manufactured with 17-4 PH stainless steel (1.4542) with the application of 3D-DMLS printing and an EOS M270 printer. The measurement of accuracy was performed with the application of an optical stereomicroscope (KERN OZL-466). In addition to that, research into the chemical composition of the material, as well as the size of spherical agglomerates, was conducted with the application of a scanning electron microscope. The analysis of the chemical composition was conducted as well (after the sintering process). The analysis of the results based on the values received by means of measurements of the manufactured geometries was divided into three parts. Based on this, it is possible to conclude that the representation of models manufactured with the application of DMLS was comparable with the assumptions, and that the deviations between a nominal dimension and that received in the course of the research were within the following scope: 0–0.1 mm. At the final stage of research and based on the received results, two heat exchangers were manufactured.

A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression

A new co-processed, rice starch-based excipient (CS) was developed via a spray-drying technique. Native rice starch (RS) was suspended in aqueous solutions of 10%–15% cross-linked carboxymethyl rice starch (CCMS) and 0.5%–6.75% silicon dioxide (in the form of sodium silicate), before spray drying. The resulting CSs were obtained as spherical agglomerates, with improved flowability. The compressibility study revealed an improved plastic deformation profile of RS, leading to better compaction and tensile strength. The presence of CCMS also ensured a rapid disintegration of the compressed tablets. CS-CCMS:SiO2 (10:2.7), prepared with 10% CCMS, 2.7% silicon dioxide, and 40% solid content, was found to exhibit the best characteristics. Compared to the two commercial DC excipients, Prosolv® and Tablettose®, the flow property of CS-CCMS:SiO2 (10:2.7) was not significantly different, while the tensile strength was 23%: lower than that of Prosolv® but 4 times higher than that of Tablettose® at 196 MPa compression force. The disintegration time of CS-CCMS:SiO2 (10:2.7) tablet (28 s) was practically identical to that of Tablettose® tablet (26 s) and far superior to that of Prosolv® tablet (>30 min). These results show that CSs could potentially be employed as a multifunctional excipient for the manufacturing of commercial tablets by DC.