Evaluation of Subantimicrobial Dose Doxycycline as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Diabetes: A Randomized, Placebo- Controlled Clinical Trial

2010 ◽  
Vol 01 (01) ◽  
Author(s):  
Vikas Deo
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Patients With Diabetes

Evaluation of Subantimicrobial Dose Doxycycline as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Diabetes: A Randomized, Placebo-Controlled Clinical Trial

2010 ◽  
Vol 11 (3) ◽  
pp. 9-16 ◽  
Author(s):  
Satish Gupta ◽  
Manohar L. Bhongade ◽  
Vikas Deo ◽  
Ritika Jaiswal
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Diabetic Patients ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Root Planing ◽  
Patients With Diabetes

Abstract Aim Diabetic patients have more severe periodontal destruction, but periodontal therapy can improve metabolic control. Recently, interest has focused on the use of subantimicrobial dose doxycycline (SDD) as a treatment paradigm. Therefore, this study was undertaken to evaluate clinical efficacy of SDD with scaling and root planning (SRP) in chronic periodontitis patients with diabetes. Methods and Materials Twenty chronic periodontitis patients with diabetes mellitus were randomly allocated to either a test and a control group. Clinical measurements were recorded at baseline and at six months for probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (GR). After SRP, patients in the test group were instructed to take SDD 20-mg capsules twice a day while patients in the control group took a placebo twice a day. Both groups were on this regimen for a six-month period. Results A greater reduction in mean PPD was demonstrated in patients in the test group compared to the control group. The mean CAL increase observed in the test group was significantly greater (0.67 mm) than that in the control group. Conclusion It can be concluded that SRP, in conjunction with the SDD therapy described, is more effective then SRP alone in terms of CAL gain and PPD reduction in diabetic patients with severe periodontal disease. Clinical Significance Given the widespread prevalence of both chronic periodontitis and diabetes, the proposed treatment approach will prove to be of great value and contribute significantly to the overall health of the patients. Citation Deo V, Gupta S, Bhongade ML, Jaiswal R. Evaluation of Subantimicrobial Dose Doxycycline as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Diabetes: A Randomized, Placebo-Controlled Clinical Trial. J Contemp Dent Pract [Internet]. 2010 May; 11(3):009-016. Available from: http://www.thejcdp.com/journal/view/volume11- issue3-deo.

Adjunctive Effects of Systemic Amoxicillin and Metronidazole with Scaling and Root Planing: A Randomized, Placebo Controlled Clinical Trial

2007 ◽  
Vol 8 (5) ◽  
pp. 51-59 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Mohammad Reza Talebi-ardakani ◽  
Ahmad Haerian-ardakani ◽  
Hengame Zandi ◽  
Shokouh Taghipour ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Scaling And Root Planing ◽  
Double Blind ◽  
Root Planing ◽  
Number Of Patients ◽  
Significant Difference ◽  
Microbiological Testing ◽  
Clinical Changes

Abstract Aims Aims: The objective of this study was to investigate the effect of the systemic administration of metronidazole and amoxicillin as an adjunct to initial periodontal therapy in patients with moderate to severe chronic periodontitis. Methods and Materials This randomized, double blind, placebo controlled parallel study involved 50 adult patients with untreated periodontitis who were randomly assigned to receive either a full-mouth scaling and root planing along with systemic metronidazole and amoxicillin (T group) or scaling and root planing with a placebo (P group). Clinical measurements including probing depth (PD), clinical attachment levels (CAL), Plaque Index (PI), and Bleeding Index (BI) were recorded at baseline and six to eight weeks after therapy. The deepest pocket was selected and samples for microbiological testing were taken. Patients received coded study medications of either 500 mg amoxicillin in combination with 250 mg metronidazole or an identical placebo every eight hours for seven days following scaling and root planing. Results There was a significant change in PD (P=0.0001), CAL (P=0.00001), PI (P<0.05), and BI (P<0.05) in the T group compared to the placebo group after therapy. Parallel to the clinical changes, treatment significantly reduced the number of Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and P. intermedia (Pi) compared with baseline in the T group (P=0.003, 0.021 and 0.0001, respectively). However, in the P group only the Pi colony count was reduced significantly (P=0.0001). After therapy, there was a significant difference between the T and P groups in the number of patients negative for Aa, Pg, and Pi (Pv = 0.033). Conclusions The significant differences between treatment and placebo groups are in line with other studies and support the considerable adjunctive benefits of the combination of amoxicillin and metronidazole in the treatment of chronic periodontitis. Citation Moeintaghavi A, Talebi-ardakani MR, Haerian-ardakani A, Zandi H, Taghipour S, Fallahzadeh H, Pakzad A, Fahami N. Adjunctive Effects of Systemic Amoxicillin and Metronidazole with Scaling and Root Planing: A Randomized, Placebo Controlled Clinical Trial. J Contemp Dent Pract 2007 July;(8)5:051-059.

Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial

2006 ◽  
Vol 33 (11) ◽  
pp. 819-828 ◽  
Author(s):  
Marcelo Faveri ◽  
Lauren Christine Gursky ◽  
Magda Feres ◽  
Jamil Awad Shibli ◽  
Sergio Luiz Salvador ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Scaling And Root Planing ◽  
Root Planing
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