scholarly journals The Predictive Value of Pretreatment 18-F-FDG-PET-CT in Locally Advanced Nasopharyngeal Cancer Patients Treated Definitively with Induction Chemotherapy Followed by Concurrent Chemo-Radiotherapy

2014 ◽  
Vol 05 (01) ◽  
Author(s):  
Hala A Zaghloul
Keyword(s):  
Cancer Patients ◽  
Induction Chemotherapy ◽  
Predictive Value ◽  
Fdg Pet ◽  
Locally Advanced ◽  
Nasopharyngeal Cancer ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Prognostic Value of Sarcopenia in Patients Treated by Radiochemotherapy for Locally Advanced Oesophageal Cancer

2020 ◽  
Author(s):  
Romain Mallet ◽  
Romain Modzelewski ◽  
Justine Lequesne ◽  
Pierre Decazes ◽  
Hugues Auvray ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cancer Patients ◽  
Oesophageal Cancer ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Locally Advanced ◽  
Ct Images ◽  
Pet Ct ◽  
Nutritional Risk Index ◽  
Fdg Pet Ct

Abstract Background Sarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including patients undergoing surgery for limited oesophageal cancer. Concomitant chemo-radiotherapy is the standard treatment for locally-advanced tumour, not accessible to surgical resection. Using automated delineation of the skeletal muscle, we have investigated the prognostic value of sarcopenia in locally advanced oesophageal cancer patients treated by curative-intent chemo-radiotherapy. Methods The clinical, nutritional, anthropometric, and functional-imaging ( 18 FDG-PET/CT) data were collected in 97 patients treated between 2006 and 2012 in our institution (RTEP3). The skeletal muscle area was automatically delineated on cross-sectional CT images acquired at the 3 rd . lumbar vertebra level and divided by the patient’s squared height (SML3/h 2 ) to obtain the Skeletal Muscle Index (SMI). The primary endpoint was overall survival probability. Results Seventy-six deaths were reported. The median survival time was 27 [95% Confidence Interval 23 – 40] months for the whole population. Univariate analyses (Cox Proportional Hazard Model) showed decreased survival probabilities in patients with reduced SMI, WHO >0, Body Mass Index ≤21, and Nutritional Risk Index ≤97.5. Multivariate analyses showed that reduced SMI (Hazard Ratio 0.948 [0.919 - 0.978] and male sex (2.977 [1.427 - 6.213] were significantly associated to decreased survival. Using Receiver Operating Characteristics curves, the Area Under the Curve (AUC) was 0.73 in males (p=0.0002], the optimal threshold being 51.5 cm 2 /m 2 . In women, the AUC was 0.65 (p=0.19). Conclusion Sarcopenia is a powerful independent prognostic factor, associated with a rise of the overall mortality in patients treated exclusively by radiochemotherapy for a locally advanced oesophageal cancer. L3 CT images are easily gathered from 18 FDG-PET/CT acquisitions

THE ROLE OF 18-FDG PET-CT IN LOCALLY ADVANCED HEAD AND NECK CANCER PATIENTS: EARLY AND LATE RESPONSE TO RADIOCHEMOTHERAPY

2011 ◽  
Vol 98 ◽  
pp. S45-S46
Author(s):  
F. Micciche ◽  
F. Bussu ◽  
R. Autorino ◽  
M. Balducci ◽  
G. Chiloiro ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Locally Advanced ◽  
Late Response ◽  
Advanced Head ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals 0173 Predictive value of 18F-FDG PET-CT in primary breast cancer patients receiving neoadjuvant chemotherapy

The Breast ◽  
2009 ◽  
Vol 18 ◽  
pp. S61-S62
Author(s):  
J.W.H. Tsang ◽  
D. Yeung ◽  
A.C.Y. Chan ◽  
C.H.N. Wong ◽  
L.W.S. Leung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Predictive Value ◽  
Fdg Pet ◽  
Primary Breast Cancer ◽  
Breast Cancer Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Use of 18F-FDG PET/CT Imaging for Radiotherapy Target Volume Delineation after Induction Chemotherapy and for Prognosis of Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN)

2018 ◽  
Author(s):  
Viktoras Rudžianskas ◽  
Erika Korobeinikova ◽  
Milda Rudžianskienė ◽  
Evelina Jaselskė ◽  
Diana Adlienė ◽  
...  
Keyword(s):  
Induction Chemotherapy ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Primary Tumour ◽  
Locally Advanced ◽  
Tumour Volume ◽  
Percentage Decrease ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Background and objectives: Induction chemotherapy (ICT) before definitive chemoradiation (CRT) gives high response rates in LA-SCCHN. However, pre-ICT gross tumour volume (GTV) for radiotherapy (RT) planning is still recommended. As 18F-FDG PET/CT has an advantage of biological tumour information comparing to standard imaging methods, we aimed to evaluate the feasibility of 18F-FDG PET/CT-based post-ICT GTV delineation for RT planning in LA-SCCHN and to assess the prognostic value of PET parameters: maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG). Methods: 47 LA-SCCHN patients were treated with 3 cycles of ICT (docetaxel, cisplatin, and 5-fluorouracil) followed by CRT (70 Gy in 35 fractions with weekly cisplatin). Pre- and post-ICT PET/CT examinations were acquired. Planning CT was co-registered with post-ICT PET/CT and RT target volumes were contoured according to post-ICT PET. Post-ICT percentage decrease of SUVmax, MTV and TLG in primary tumour and metastatic regional lymphnodes (LN) was counted. Loco-regional failure patterns, 3-year progression free (PFS) and overall survival (OS) were evaluated. Results: 3-year PFS and OS rates for study population were 67% and 61% respectively. 31.9% of patients progressed loco-regionally. All progresses were localised in high-to-intermediate dose (60–70 Gy) RT volumes and none in low dose (50 Gy) volumes. Decrease of SUVmax ≥74% (p = 0.03), MTV ≥ 68% (p = 0.04), TLG ≥ 76% (p = 0.02) in primary tumour, and LN TLG decrease ≥74% (p = 0.03) were associated with PFS. Decrease of primary tumour SUVmax ≥ 74% (p = 0.04), MTV ≥ 69% (p = 0.04), TLG ≥ 74% (p = 0.02) and LN TLG ≥ 73% (p = 0.02) were prognostic factors for OS. Conclusions: According to our results, 18F-FDG PET/CT-based post-ICT GTV delineation is feasible strategy without negative impact on loco-regional control and survival. Percentage decrease of metabolic PET parameters SUVmax, MTV and TLG has a prognostic value in LA-SCCHN.

Prediction of pathological response using 18F FDG PET/CT derived metabolic parameters in locally advanced breast cancer patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Salwa Abd El-Gaid ◽  
Marwa Nabil AbdelHafez ◽  
Ghada Mohamed ◽  
Mohamed Samy Saied Elazab ◽  
Mai Amr Elahmadawy
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Pathological Response ◽  
Breast Cancer Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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